PLN - phospholamban Gene

Also Known as PLB; CMD1P; CMH18

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5350

About PLN

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:118,548,296-118,561,716 (from NCBI)

This gene has 1 transcript (splice variant), 187 orthologues and is associated with 5 phenotypes. Biased expression in heart (RPKM 615.2), gall bladder (RPKM 62.5) and 1 other tissue.

Summary

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum CA(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the CA(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]

PLN Products (1)

mRNA	Protein	Name
NM_002667.5	NP_002658.1	cardiac phospholamban

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase inhibitor activity	IDA IDA: Inferred from direct assay	19708671	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15598648	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	19708671	GOA
involved in negative regulation of ATPase-coupled calcium transmembrane transporter activity	IDA IDA: Inferred from direct assay	19708671	GOA
involved in negative regulation of calcium ion binding	IDA IDA: Inferred from direct assay	19708671	GOA
involved in negative regulation of calcium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	19708671	GOA
involved in negative regulation of calcium ion transport	IDA IDA: Inferred from direct assay	19708671	GOA
involved in negative regulation of heart rate	IMP IMP: Inferred from mutant phenotype	16432188	GOA
involved in regulation of ATPase-coupled calcium transmembrane transporter activity	IDA IDA: Inferred from direct assay	22427649	GOA
involved in regulation of calcium ion transport	IDA IDA: Inferred from direct assay	22427649	GOA
involved in regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	16432188	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of calcium ion-transporting ATPase complex	IDA IDA: Inferred from direct assay	19708671	GOA
located in membrane	IDA IDA: Inferred from direct assay	19708671	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLN Protein Structure

Phospholamban

0
52 a.a.

Protein Preferred Names	Protein Names
cardiac phospholamban

PLN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLN	P26678	LDLRAD1	Homo sapiens	Q5T700	Validated Y2H	32296183
Intra	PLN	P26678	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
Intra	PLN	P26678	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
Intra	PLN	P26678	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	24722188
Intra	PLN	P26678	SDC3	Homo sapiens	A0A0S2Z4U3	Y2H Array	32296183
Intra	PLN	P26678	SDC3	Homo sapiens	A0A0S2Z4U3	Y2H Prey Pooling	32296183
Intra	PLN	P26678	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	PLN	P26678	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	PLN	P26678	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	PLN	P26678	LSMEM2	Homo sapiens	Q8N112	Y2H Array	32296183
Intra	PLN	P26678	LSMEM2	Homo sapiens	Q8N112	Y2H Prey Pooling	32296183
Intra	PLN	P26678	LSMEM2	Homo sapiens	Q8N112	Validated Y2H	32296183
Intra	PLN	P26678	SPAG4	Homo sapiens	Q9NPE6	Validated Y2H	32296183
Intra	PLN	P26678	SPAG4	Homo sapiens	Q9NPE6	Y2H Array	32296183
Intra	PLN	P26678	SPAG4	Homo sapiens	Q9NPE6	Y2H Prey Pooling	32296183
Intra	PLN	P26678	TMEM45A	Homo sapiens	Q9NWC5	Y2H Prey Pooling	32296183
Intra	PLN	P26678	TMEM45A	Homo sapiens	Q9NWC5	Validated Y2H	32296183
Intra	PLN	P26678	TMEM45A	Homo sapiens	Q9NWC5	Y2H Array	32296183
Intra	PLN	P26678	MGST2	Homo sapiens	Q99735	Y2H Prey Pooling	32296183
Intra	PLN	P26678	MGST2	Homo sapiens	Q99735	Validated Y2H	32296183
Intra	PLN	P26678	MGST2	Homo sapiens	Q99735	Y2H Array	32296183
Intra	PLN	P26678	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	PLN	P26678	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	PLN	P26678	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	PLN	P26678	HIBADH	Homo sapiens	P31937	Validated Y2H	32296183
Intra	PLN	P26678	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	PLN	P26678	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	PLN	P26678	RTN3	Homo sapiens	O95197-3	Y2H Array	32296183
Intra	PLN	P26678	RTN3	Homo sapiens	O95197-3	Y2H Prey Pooling	32296183
Intra	PLN	P26678	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	PLN	P26678	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	PLN	P26678	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	PLN	P26678	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	PLN	P26678	TMEM179B	Homo sapiens	Q7Z7N9	Validated Y2H	32296183
Intra	PLN	P26678	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	PLN	P26678	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	PLN	P26678	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Array	32296183
Intra	PLN	P26678	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Prey Pooling	32296183
Intra	PLN	P26678	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	PLN	P26678	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	PLN	P26678	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	PLN	P26678	STX2	Homo sapiens	P32856-2	Validated Y2H	32296183
Intra	PLN	P26678	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	PLN	P26678	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	PLN	P26678	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	PLN	P26678	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	PLN	P26678	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	PLN	P26678	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	PLN	P26678	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	PLN	P26678	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
Intra	PLN	P26678	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
Intra	PLN	P26678	SLC34A2	Homo sapiens	O95436-2	Y2H Prey Pooling	32296183
Intra	PLN	P26678	SLC34A2	Homo sapiens	O95436-2	Y2H Array	32296183
Intra	PLN	P26678	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	PLN	P26678	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	PLN	P26678	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	PLN	P26678	ATP6V0E1	Homo sapiens	O15342	Y2H Array	32296183
Intra	PLN	P26678	ATP6V0E1	Homo sapiens	O15342	Y2H Prey Pooling	32296183
Intra	PLN	P26678	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	PLN	P26678	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	PLN	P26678	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	PLN	P26678	SLC14A2	Homo sapiens	Q15849	Y2H Prey Pooling	32296183
Intra	PLN	P26678	SLC14A2	Homo sapiens	Q15849	Validated Y2H	32296183
Intra	PLN	P26678	SLC14A2	Homo sapiens	Q15849	Y2H Array	32296183
Intra	PLN	P26678	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	PLN	P26678	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	PLN	P26678	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	PLN	P26678	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	PLN	P26678	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	PLN	P26678	GJA8	Homo sapiens	P48165	Validated Y2H	32296183
Intra	PLN	P26678	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	PLN	P26678	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	PLN	P26678	SPACA1	Homo sapiens	Q9HBV2	Y2H Array	32296183
Intra	PLN	P26678	SPACA1	Homo sapiens	Q9HBV2	Y2H Prey Pooling	32296183
Intra	PLN	P26678	SPACA1	Homo sapiens	Q9HBV2	Validated Y2H	32296183
Intra	PLN	P26678	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	PLN	P26678	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	PLN	P26678	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	PLN	P26678	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	PLN	P26678	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	PLN	P26678	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	PLN	P26678	PLPPR1	Homo sapiens	Q8TBJ4	Y2H Prey Pooling	32296183
Intra	PLN	P26678	PLPPR1	Homo sapiens	Q8TBJ4	Validated Y2H	32296183
Intra	PLN	P26678	PLPPR1	Homo sapiens	Q8TBJ4	Y2H Array	32296183
Intra	PLN	P26678	TMEM52B	Homo sapiens	Q4KMG9	Validated Y2H	32296183
Intra	PLN	P26678	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	PLN	P26678	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	PLN	P26678	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	PLN	P26678	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	PLN	P26678	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	PLN	P26678	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	PLN	P26678	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	PLN	P26678	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	PLN	P26678	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	PLN	P26678	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	PLN	P26678	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	PLN	P26678	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	PLN	P26678	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	PLN	P26678	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	PLN	P26678	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	PLN	P26678	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	PLN	P26678	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	PLN	P26678	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	PLN	P26678	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	PLN	P26678	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
Intra	PLN	P26678	MFSD5	Homo sapiens	Q6N075	Y2H Array	32296183
Intra	PLN	P26678	MFSD5	Homo sapiens	Q6N075	Y2H Prey Pooling	32296183
Intra	PLN	P26678	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	PLN	P26678	TMEM45B	Homo sapiens	Q96B21	Validated Y2H	32296183
Intra	PLN	P26678	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	PLN	P26678	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	PLN	P26678	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	PLN	P26678	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	PLN	P26678	EDA	Homo sapiens	Q92838	Y2H Array	32296183
Intra	PLN	P26678	EDA	Homo sapiens	Q92838	Y2H Prey Pooling	25416956
Intra	PLN	P26678	EDA	Homo sapiens	Q92838	Y2H Prey Pooling	32296183
Intra	PLN	P26678	EDA	Homo sapiens	Q92838	Y2H Array	31515488
Intra	PLN	P26678	EDA	Homo sapiens	Q92838	Y2H Bait-Prey Pool	25910212
Intra	PLN	P26678	EDA	Homo sapiens	Q92838	Y2H Array	24722188
Intra	PLN	P26678	EDA	Homo sapiens	Q92838	Y2H Array	25910212
Intra	PLN	P26678	EDA	Homo sapiens	Q92838	Validated Y2H	25910212
Intra	PLN	P26678	EDA	Homo sapiens	Q92838	Validated Y2H	32296183
Intra	PLN	P26678	EDA	Homo sapiens	Q92838	Y2H Array	25416956
Intra	PLN	P26678	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	PLN	P26678	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212
Intra	PLN	P26678	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	PLN	P26678	TMEM205	Homo sapiens	Q6UW68	Y2H Array	32296183
Intra	PLN	P26678	TMEM205	Homo sapiens	Q6UW68	Y2H Prey Pooling	32296183
Intra	PLN	P26678	TMEM205	Homo sapiens	Q6UW68	Validated Y2H	32296183
Intra	PLN	P26678	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	PLN	P26678	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	PLN	P26678	DMPK	Homo sapiens	Q09013	Anti Tag CoIP	15598648
Intra	PLN	P26678	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	25910212
Intra	PLN	P26678	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	25910212
Intra	PLN	P26678	CREB3L1	Homo sapiens	Q96BA8	Y2H Bait-Prey Pool	25910212
Intra	PLN	P26678	SIT1	Homo sapiens	Q9Y3P8	Y2H Prey Pooling	32296183
Intra	PLN	P26678	SIT1	Homo sapiens	Q9Y3P8	Validated Y2H	32296183
Intra	PLN	P26678	SIT1	Homo sapiens	Q9Y3P8	Y2H Array	32296183
Intra	PLN	P26678	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	PLN	P26678	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	PLN	P26678	BIK	Homo sapiens	Q13323	Validated Y2H	32296183
Intra	PLN	P26678	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	PLN	P26678	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	PLN	P26678	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	PLN	P26678	MS4A7	Homo sapiens	Q9GZW8	Y2H Prey Pooling	32296183
Intra	PLN	P26678	MS4A7	Homo sapiens	Q9GZW8	Validated Y2H	32296183
Intra	PLN	P26678	MS4A7	Homo sapiens	Q9GZW8	Y2H Array	32296183
Intra	PLN	P26678	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	PLN	P26678	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	PLN	P26678	FKBP8	Homo sapiens	Q14318	Y2H Array	32296183
Intra	PLN	P26678	FKBP8	Homo sapiens	Q14318	Y2H Prey Pooling	32296183
Intra	PLN	P26678	FKBP8	Homo sapiens	Q14318	Validated Y2H	32296183
Intra	PLN	P26678	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	PLN	P26678	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	32296183
Intra	PLN	P26678	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
Intra	PLN	P26678	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
Intra	PLN	P26678	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	25910212
Intra	PLN	P26678	BCL2L13	Homo sapiens	Q9BXK5	Y2H Bait-Prey Pool	25910212
Intra	PLN	P26678	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	25910212
Intra	PLN	P26678	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	PLN	P26678	KIR2DL3	Homo sapiens	P43628	Validated Y2H	32296183
Intra	PLN	P26678	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72275	Cardiac phospholamban/PLN, Human (P.pastoris, GST)	P26678 (M1-L52)	≥ 90%, as determined by reducing SDS-PAGE.

PLN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81873	Phospho-Phospholamban (Ser16) Antibody (YA1618)	WB	Human, Mouse
HY-P81873A	Phospho-Phospholamban (Ser16) Antibody (YA1618)(PBS only)	WB	Human, Mouse
HY-P81877	Phospholamban Antibody (YA1622)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P81877A	Phospholamban Antibody (YA1622)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P87030	Phospho-Phospholamban (S16) Antibody (YA6723)	WB	Mouse, Rat

Related Diseases

Diseases	Alias
Cardiomyopathy, Dilated, 1p	Dilated Cardiomyopathy 1p CMD1P Cardiomyopathy, Dilated 1p Cardiomyopathy, Dilated, Type 1p
Cardiomyopathy, Familial Hypertrophic, 18	Hypertrophic Cardiomyopathy 18 CMH18 Cardiomyopathy, Hypertrophic, 18 Cardiomyopathy Familial Hypertrophic 18 Cardiomyopathy, Familial Hypertrophic 18 Cardiomyopathy, Hypertrophic, Familial, Type 18
Arrhythmogenic Right Ventricular Dysplasia, Familial, 9	Arrhythmogenic Right Ventricular Dysplasia 9 ARVD9 Arrhythmogenic Right Ventricular Cardiomyopathy 9 Arvc9 Familial Arrhythmogenic Right Ventricular Dysplasia 9 Dysplasia, Arrhythmogenic Right Ventricular, Type 9
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Familial Isolated Dilated Cardiomyopathy	Familial Or Idiopathic Dilated Cardiomyopathy
Cardiac Arrest	Cardiopulmonary Arrest Circulatory Arrest Heart Arrest
Congestive Heart Failure	Congestive Heart Disease Heart Failure Cardiac Failure Congestive Chf Weak Heart Heart Failure Congestive Ccf - [Congestive Cardiac Failure] Chf - [Congestive Heart Failure] Congestive Cardiac Diseases Congested Heart Failure Congestive Cardiac Failure Cardiac Anasarca Cardiac Oedema Cardiac Stasis Cardiovascular Oedema Cardiac Hydrops Congestive Failure Heart Congestion Heart Fluid Oedematous Heart
Brody Disease	Brody Myopathy BROD Sarcoplasmic Reticulum -Ca2+Atpase Deficiency Myopathy, Brody
Schwartz-Jampel Syndrome, Type 1	Schwartz-Jampel Syndrome SJS1 Schwartz-Jampel-Aberfeld Syndrome Sjs Chondrodystrophic Myotonia Schwartz-Jampel Syndrome Type 1 Sja Syndrome Aberfeld Syndrome Burton Skeletal Dysplasia Burton Syndrome Catel-Hempel Syndrome Myotonic Chondrodystrophy Myotonic Myopathy, Dwarfism, Chondrodystrophy, Ocular And Facial Anomalies Osteochondromuscular Dystrophy Myotonic Myopathy, Dwarfism, Chondrodystrophy, And Ocular And Facial Abnormalities Schwartz-Jampel Syndrome 1 Dysostosis Enchondralis Metaepiphysaria, Catel-Hempel Type Catel-Hempel Type Dysostosis Enchondralis Metaepiphysaria Schwartz Jampel Syndrome Myotonic Myopathy Dwarfism Chondrodystrophy And Ocular And Facial Abnormalities Schwartz Jampel Aberfeld Syndrome Congenital Blepharophimosis, Myopia, Myopathy Syndrome Kniest-Like Dysplasia With Pursed Lips And Ectopia Lentis
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Periarthritis
Cantu Syndrome	Hypertrichotic Osteochondrodysplasia Hypertrichotic Osteochondrodysplasia Cantu Type Cantú Syndrome Craniofaciocardioskeletal Syndrome Hypertrichosis-Osteochondrodysplasia-Cardiomegaly Syndrome Congenital Hypertrichosis-Acromegaloid Facial Features Spectrum Congenital Hypertrichosis-Coarse Facial Features Spectrum HTOCD Osteochondrodysplasia, Hypertrichotic
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137561	Bexotegrast	Inhibitor	99.74%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-47888	PLN-1474	Inhibitor	99.35%	Unkown
HY-148776	PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50)		/	Unkown
HY-137561A	Bexotegrast hydrochloride	Inhibitor	/	Unkown
HY-RS10727	PLN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17361	Pln Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23815	Pln Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLN	RGD	RGD:619894
Felis catus	PLN	VGNC	VGNC:68906
Mus musculus	PLN	MGD	MGI:97622
Canis familiaris	PLN	VGNC	VGNC:44700
Bos taurus	PLN	VGNC	VGNC:33038
Others	PLN	NCBI