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Cat. No.: HY-137561A

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Bexotegrast hydrochloride

(Synonyms: PLN-74809 hydrochloride)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Bexotegrast hydrochloride (PLN-74809 hydrochloride) is a small molecule dual selective inhibitor with activity targeting αVβ1 and αVβ6. Bexotegrast hydrochloride is used for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). Bexotegrast hydrochloride inhibits the activation of TGF-β1 by blocking the function of these integrins, thereby preventing the growth of fibrous tissue in the lungs and bile ducts.

For research use only. We do not sell to patients.

CAS No.: 2775365-40-5
Formula: C₂₇H₃₈Cl₂N₆O₃
Molecular Weight:565.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Bexotegrast hydrochloride Chemical Structure

CAS No.: 2775365-40-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Integrin Isoforms :

Chemical Information

CAS No. 2775365-40-5
Molecular Weight 565.54
Formula C₂₇H₃₈Cl₂N₆O₃
SMILES

COCCN(CCCCC(N1)=CC=C2C1=NCCC2)CC[C@@H](C(O)=O)NC3=NC=NC4=C3C=CC=C4.Cl.Cl
Synonyms

PLN-74809 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Science

Antifibrotic drug finerenone restores fertility in premature ovarian insufficiency. [Abstract]

2026 Feb 5;391(6785):eadz4075. PMID: 41643022
Phytomedicine

Jiawei yanghe decoction alleviates osteoporotic osteoarthritis by promoting MSC osteogenic differentiation and homing via ITGB6/TGF-β/CXCR4 pathway. [Abstract]

2025 Nov:147:157203. PMID: 40929885
bioRxiv

Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosis. [Abstract]

2026 Jan 31:2026.01.30.702837. PMID: 41659605

Bexotegrast hydrochloride purchased from MedChemExpress. Usage Cited in: bioRxiv. 2026 Jan 31:2026.01.30.702837. [Abstract]

SFTPC^tdTomato and ACTA2^GFP fluorescence in live co-cultures of SFTPC^I73T mutant iAT2s and iLM treated with 2 μM Bexotegrast for 1 week, as compared to vehicle control (treatment starting on the first day of co-culture). Scale bars = 400 μm.

Bexotegrast hydrochloride purchased from MedChemExpress. Usage Cited in: bioRxiv. 2026 Jan 31:2026.01.30.702837. [Abstract]

RT-qPCR analysis showing fold change expression (normalized to iLM co-cultured control) of fibrotic markers in EPCAM- sorted cells from co-cultures of iLM with SFTPC^I73T mutant iAT2s or iLM cultured alone. N = 5 for SB525334 (1 μM; 1 week), N = 6 for Bexotegrast (2 μM; 1 week), symbol shapes indicate experimental replicates, i.e. multiple wells of the same experiment.

Bexotegrast hydrochloride purchased from MedChemExpress. Usage Cited in: bioRxiv. 2026 Jan 31:2026.01.30.702837. [Abstract]

Immunofluorescence staining for KRT17 protein in co-cultures of SFTPCI73T mutant iAT2s and iLM. The results showed that treatment of co-cultures of SFTPC^I73T mutant iAT2s and iLM for 7 days with either SB525334 (1 μM; 1 week) or Bexotegrast (2 μM; 1 week), compared to vehicle-treated controls, abolished KRT17 protein expression in co-cultured SFTPC^I73T mutant iAT2s. Scale bars = 100 μm. Hoechst = nuclei.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Anindya Roy, et al. De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8. Nat Commun. 2023 Sep 13;14(1):5660. [Content Brief]

[2]. Bexotegrast in Patients with Idiopathic Pulmonary Fibrosis: The INTEGRIS-IPF Clinical Trial [Content Brief]

[3]. Martin L Decaris, et al. Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF. Respir Res. 2021 Oct 19;22(1):265. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Bexotegrast hydrochloride

3 Cited Publications

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Biological Activity
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Publications (3)
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Bexotegrast hydrochloride purchased from MedChemExpress. Usage Cited in: bioRxiv. 2026 Jan 31:2026.01.30.702837. [Abstract]

Customer Validation
SFTPC^tdTomato and ACTA2^GFP fluorescence in live co-cultures of SFTPC^I73T mutant iAT2s and iLM treated with 2 μM Bexotegrast for 1 week, as compared to vehicle control (treatment starting on the first day of co-culture). Scale bars = 400 μm.
1/16

Bexotegrast hydrochloride purchased from MedChemExpress. Usage Cited in: bioRxiv. 2026 Jan 31:2026.01.30.702837. [Abstract]

Customer Validation
RT-qPCR analysis showing fold change expression (normalized to iLM co-cultured control) of fibrotic markers in EPCAM- sorted cells from co-cultures of iLM with SFTPC^I73T mutant iAT2s or iLM cultured alone. N = 5 for SB525334 (1 μM; 1 week), N = 6 for Bexotegrast (2 μM; 1 week), symbol shapes indicate experimental replicates, i.e. multiple wells of the same experiment.
1/16

Bexotegrast hydrochloride purchased from MedChemExpress. Usage Cited in: bioRxiv. 2026 Jan 31:2026.01.30.702837. [Abstract]

Customer Validation
Immunofluorescence staining for KRT17 protein in co-cultures of SFTPCI73T mutant iAT2s and iLM. The results showed that treatment of co-cultures of SFTPC^I73T mutant iAT2s and iLM for 7 days with either SB525334 (1 μM; 1 week) or Bexotegrast (2 μM; 1 week), compared to vehicle-treated controls, abolished KRT17 protein expression in co-cultured SFTPC^I73T mutant iAT2s. Scale bars = 100 μm. Hoechst = nuclei.

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Bexotegrast hydrochloride

Publications Citing Use of MedChemExpress (MCE) Bexotegrast hydrochloride

All Integrin Isoforms

Biological Activity

Chemical Information

Publications (3)

Purity & Documentation

References

Calculators

Help & FAQs

Bexotegrast hydrochloride Related Classifications

HY-137561A Related Classifications