Phospho-Phospholamban (S16) Antibody (YA6723)

Cat. No.: HY-P87030: Ficha de datos User Guide for Antibodies
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Phospho-Phospholamban (S16) Antibody (YA6723) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Phospholamban (S16).

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

Phospho-Phospholamban (S16) Antibody (YA6723) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Phospholamban (S16).

Host

Rabbit

Clonality

Recombinant,Monoclonal

Peso molecular

Predicted band size: 6 kDa;

Observed band size: 6/12/24 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Mouse, Rat

SwissProt ID

P26678

Gene ID

5350 [NCBI]

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding Ser16 of human phospholamban protein.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000

Pureza	affinity purified.	Conjugation	Non-conjugated
Modification	Phosphorylated	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle (By similarity). Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP (By similarity). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). Also inhibits the activity of ATP2A3/SERCA3 (By similarity). Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation (By similarity). In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning (By similarity)

Subcellular Localization：Endoplasmic reticulum membrane,Sarcoplasmic reticulum membrane,Mitochondrion membrane,Membrane

Expression：
Tissue_Specificity: Heart muscle (at protein level)

Subunit：Homopentamer (PubMed:16043693, PubMed:16897780)

Synonyms

Cardiac phospholamban antibody; CMD1P antibody; CMH18 antibody; PLB antibody; Pln antibody; PPLA_HUMAN antibody;

Documentación

User Guide for Antibodies (1077 KB)