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  5. Phospho-Phospholamban (Ser16) Antibody (YA1618)

Phospho-Phospholamban (Ser16) Antibody (YA1618)

Cat. No.: HY-P81873
COA
SDS
User Guide for Antibodies Technical Support

Phospho-Phospholamban (Ser16) Antibody (YA1618) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Phospholamban (Ser16).

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Top Publications Citing Use of Products

1 Publications Citing Use of MCE Phospho-Phospholamban (Ser16) Antibody (YA1618)

  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Description

Description

Phospho-Phospholamban (Ser16) Antibody (YA1618) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Phospholamban (Ser16).
Host

Rabbit
Clonality

Recombinant,Monoclonal
Masse moléculaire
Predicted band size: 6 kDa;
Observed band size: 12,24 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse
SwissProt ID
Gene ID
Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser16 of human Phospholamban
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:5000
Sensitivity Endogenous Pureté Affinity Purified
Conjugation Non-conjugated Modification Phosphorylated
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Livraison

Shipping with blue ice.
Background
Function：Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle (By similarity). Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP (By similarity). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). Also inhibits the activity of ATP2A3/SERCA3 (By similarity). Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation (By similarity). In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning (By similarity)
Subcellular Localization：Endoplasmic reticulum membrane; Single-pass membrane protein; Sarcoplasmic reticulum membrane; Single-pass membrane protein; Mitochondrion membrane; Single-pass membrane protein; Membrane; Single-pass membrane protein
Expression：
Tissue_specificity:Cardiac muscle (protein levels)
Subunit：Homopentamer (PubMed:16043693, PubMed:16897780). Can also form heterooligomers witH2O2her sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) regulators ARLN, ERLN, SLN and STRIT1/DWORF (PubMed:36523160).
RRID
Database

Entrez Gene: 5350 Human ; 18821 Mouse ;

SwissProt: P26678 Human ; P61014 Mouse ;

OMIM: 609909 Human

Research Field

Signal Transduction
Synonyms
PLN; PLB; Cardiac phospholamban; PLB
Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Phospho-Phospholamban (Ser16) Antibody (YA1618) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nom du produit:
Phospho-Phospholamban (Ser16) Antibody (YA1618)
Cat. No.:
HY-P81873
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