Search Result
Results for "
methotrexate-
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
15
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-14519
-
-
-
- HY-13664
-
|
Leucovorin calcium; Calcium folinate
|
Antifolate
Endogenous Metabolite
|
Cancer
|
|
Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .
|
-
-
- HY-17556
-
Folinic acid
Maximum Cited Publications
16 Publications Verification
leucovorin
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Antifolate
Endogenous Metabolite
|
Cancer
|
|
Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity .
|
-
-
- HY-14519A
-
|
Amethopterin disodium; CL14377 disodium; WR19039 disodium
|
Antifolate
DNA/RNA Synthesis
ADC Payload
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
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Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
|
-
-
- HY-14519S
-
|
|
Antifolate
DNA/RNA Synthesis
ADC Payload
Apoptosis
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Inflammation/Immunology
Cancer
|
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Methotrexate-d3 (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
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-
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- HY-B0080
-
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Leucovorin calcium salt pentahydrate
|
Antifolate
Endogenous Metabolite
|
Cancer
|
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Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .
|
-
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- HY-N1346
-
Robinin
5 Publications Verification
|
Toll-like Receptor (TLR)
Apoptosis
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Inflammation/Immunology
Cancer
|
|
Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect .
|
-
-
- HY-127009
-
|
Levofolinic acid; Levofolene
|
Lysyl Oxidase
Apoptosis
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Metabolic Disease
Cancer
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Levoleucovorin (Levofolinic acid; Levofolene) is the pharmacologically and orally active levoisomer of Folinic acid (HY-17556), a synthetic folate analogue. Levoleucovorin can inhibit LOXL2 with an IC50 of 68.81 μM. Levoleucovorin can inhibit cancer cells proliferation, migration and induce apoptosis. Levoleucovorin can be used as a rescue agent for high-dose Methotrexate (HY-14519). Levoleucovorin can reduce the frequency of embryonic malformations. Levoleucovorin can be used for the research of can and endocrinology, such as breast cancer and osteosarcoma .
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-
-
- HY-14519B
-
|
Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate
|
Biochemical Assay Reagents
Antibiotic
Bacterial
|
Others
Cancer
|
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Methotrexate hydrate is a substance that affects cell growth and division. It is commonly used to fight certain diseases, especially cancer and autoimmune diseases. It works by inhibiting the process by which cells synthesize DNA.
|
-
-
- HY-108251
-
|
DAMPA
|
Antifolate
Drug Metabolite
Dihydrofolate reductase (DHFR)
Parasite
|
Infection
Inflammation/Immunology
|
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Methotrexate metabolite (DAMPA) is an active metabolite of Methotrexate. Methotrexate is a Folic acid (HY-16637) antagonist, widely used as an immunosuppressant. Methotrexate metabolite is an antimalarial agent that inhibits parasite growth under physiological folic acid conditions, with IC50 values of 446 nM and 812 nM against folic acid-sensitive strains and highly resistant strains, respectively. Methotrexate metabolite exhibits pharmacokinetic characteristics of rapid clearance and extensive metabolism, with a mean clearance rate of 1.9 l/kg/h and a mean terminal half-life of 51 minutes. Methotrexate metabolite is promising for research in the field of inflammation .
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-
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- HY-134978A
-
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SHMT
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Cancer
|
|
(+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, whose target can be traced with 13C-serine. (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate (HY-14519) . (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
-
- HY-130569
-
|
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Drug Metabolite
|
Inflammation/Immunology
Cancer
|
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7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
|
-
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- HY-17556R
-
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leucovorin (Standard)
|
Reference Standards
Antifolate
Endogenous Metabolite
|
Cancer
|
|
Folinic acid (Standard) is the analytical standard of Folinic acid. This product is intended for research and analytical applications. Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity .
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-
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- HY-W086988
-
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5-Methylbenzotriazole
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Biochemical Assay Reagents
|
Others
|
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5-Methyl-1H-benzotriazole (5-Methylbenzotriazole) is a benzotriazole derivative, and serves as a key building block for ultraviolet absorbers and light stabilizers. 5-Methyl-1H-benzotriazole reduces the photosensitizing ability of nitrate and dissolved organic matter (DOM), enhances the persistence of microorganic pollutants, inhibits the photodegradation of DOM and drug residues, and quenches the triplet excited states of DOM and methotrexate substructures. 5-Methyl-1H-benzotriazole acts as a corrosion inhibitor for copper and copper alloys, and is present in formulations of anti-icing fluids, dishwasher detergents, aircraft deicing fluids and automotive antifreezes .
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-
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- HY-133887
-
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Antifolate
DNA/RNA Synthesis
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Cancer
|
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Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent .
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-
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- HY-14519R
-
|
Amethopterin (Standard); CL14377 (Standard); WR19039 (Standard)
|
Reference Standards
Antifolate
DNA/RNA Synthesis
ADC Payload
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
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Methotrexate (Standard) is the analytical standard of Methotrexate. This product is intended for research and analytical applications. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
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-
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- HY-W047788
-
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Amino Acid Derivatives
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Others
|
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H-Dab(Boc)-OH is an amino acid derivative with a Boc protecting group, which can be used to synthesize methotrexate (MTX) analogs with antitumor and antifolate activities .
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-
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- HY-134978B
-
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SHMT
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Cancer
|
|
(-)SHIN2 is the isomer of (+)SHIN2 (HY-134978A). (+)SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+)SHIN2 synergisty with and Methotrexate (HY-14519) in vivo xenotransplantation models . (-)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
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- HY-162021
-
-
-
- HY-133624
-
|
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Drug Metabolite
|
Cancer
|
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1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519) . Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
|
-
-
- HY-17556S1
-
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Leucovorin-d4 calcium hydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
Antifolate
|
Cancer
|
|
Folinic acid-d4-1 (Leucovorin-d4-1) calcium hydrate is deuterated labeled Folinic acid (HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease Methotrexate-induced toxicity.
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-
-
- HY-W076898A
-
|
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Antibiotic
|
Others
|
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Hydroxyethyl disulfide blocks the inhibitory effect of showdomycin on methotrexate-resistant thymidylate synthase and is also protected by its substrate deoxyuridylic acid, preventing inactivation of the antibiotic .
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-
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- HY-115429
-
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(6R)-Leucovorin calcium; (6R)-Folinic acid calcium
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Drug Derivative
|
Metabolic Disease
|
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Calcium dextrofolinate is a stereoisomer of Calcium folinate. Calcium folinate (Folinic acid calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .
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-
-
- HY-P1197
-
|
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Kisspeptin Receptor
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Cardiovascular Disease
Inflammation/Immunology
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Kisspeptin-10 (mouse, rat) is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10 (mouse, rat) is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound .
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-
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- HY-135101
-
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methotrexate 5-methyl ester; γ-EMTX
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Antifolate
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Others
|
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Methotrexate γ-Methyl Ester (Methotrexate 5-methyl ester) is an impurity of the folate antagonist Methotrexate (HY-14519) .
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-
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- HY-P1197A
-
|
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Kisspeptin Receptor
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Cardiovascular Disease
Inflammation/Immunology
|
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Kisspeptin-10 (mouse, rat) TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10 (mouse, rat) TFA is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 (mouse, rat) TFA reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound .
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-
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- HY-13617
-
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CGP 30694
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Antifolate
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Cancer
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Edatrexate (CGP 30694), as known as 10-Ethyl-10-deazaaminopterin, is Methotrexate (HY-14519) analog, exhibits antitumor activity against MTX-resistant tumors. Edatrexate is an antifolate antimetabolite, can be used for reasearch of non-small-cell lung cancer, breast cancer, non-Hodgkin's lymphoma, and cancer of the head and neck .
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-
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- HY-P11101
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Biochemical Assay Reagents
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Others
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plCSA-BP is a Placental CSA-binding peptide. plCSA-BP binds specifically to trophoblasts and not to other cell types in the placenta or to CSA-expressing cells in other tissues. plCSA-BP can guide nanoparticles for the targeted delivery of payloads (such as Indocyanine green (ICG) (HY-D0711) and Methotrexate (MTX) (HY-14519)) to the placenta, promising for placenta-specific drug delivery .
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- HY-149200
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-
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- HY-14519CS
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-
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- HY-121151
-
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(±)-Amethopterin; (±)-CL14377; (±)-WR19039
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Antifolate
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Others
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(±)-Methotrexate ((±)-Amethopterin) is a racemate of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of Folic acid into Tetrahydrofolate, and inhibiting DNA synthesis .
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-
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- HY-14519D
-
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Amethopterin monohydrate; CL14377 monohydrate; WR19039 monohydrate
|
Antifolate
DNA/RNA Synthesis
ADC Payload
Apoptosis
Bacterial
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Inflammation/Immunology
Cancer
|
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Methotrexate (Amethopterin) monohydrate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
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-
-
- HY-14519AR
-
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Amethopterin disodium (Standard); CL14377 disodium (Standard); WR19039 disodium (Standard)
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Antifolate
DNA/RNA Synthesis
ADC Payload
Apoptosis
Bacterial
Reference Standards
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Inflammation/Immunology
Cancer
|
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Methotrexate (disodium) (Standard) is the analytical standard of Methotrexate (disodium). This product is intended for research and analytical applications. Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
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-
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- HY-13664R
-
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Leucovorin calcium (Standard); Calcium folinate (Standard)
|
Reference Standards
Antifolate
Endogenous Metabolite
|
Cancer
|
|
Folinic acid (calcium) (Standard) is the analytical standard of Folinic acid (calcium). This product is intended for research and analytical applications. Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .
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-
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- HY-W653912A
-
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Isotope-Labeled Compounds
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Cancer
|
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Leucovorin-d4 (Leucovorin-d4) calcium hydrate, >90% is a deuterated labeled Folinic acid (Leucovorin, HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .
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-
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- HY-17556A
-
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Leucovorin disodium
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Endogenous Metabolite
Antifolate
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Cancer
|
|
Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma .
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- HY-120050
-
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Phospholipase
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Inflammation/Immunology
|
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GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC50 value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE2 levels .
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-
-
- HY-174435
-
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P-glycoprotein
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Cancer
|
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ABCB1/ABCG2-IN-1 (Compound (S,Z)-4b) is an inhibitor of ABCB1 and ABCB2 transporters. ABCB1/ABCG2-IN-1 shows moderate activity in SW620M, -V, and –Mito variants (IC50 ≈ 50 μM). ABCB1/ABCG2-IN-1 affects methotrexate resistance in vitro. ABCB1/ABCG2-IN-1 can be studied in anticancer research .
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-
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- HY-129870
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
Diazoketone methotrexate, an analog of methotrexate, is an antitumor agent. Diazoketone methotrexate inhibits cell growth and inhibits synthesis of thymidylate .
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-
-
- HY-W745177
-
-
-
- HY-W743645
-
-
-
- HY-165164
-
|
|
Drug Intermediate
|
Cancer
|
|
Methotrexate-alpha-alanine is a prodrug for activation by enzyme-monoclonal antibody conjugates of Methotrexate (HY-14519). Methotrexate-alpha-alanine shows cytotoxicity .
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-
-
- HY-148994
-
|
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Dihydrofolate reductase (DHFR)
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Cancer
|
|
Methotrexate-γ-aspartate is a Ll210 cell dihydrofolate reductase inhibitor. Methotrexate-γ-aspartate is apparently more resistant to enzymic cleavage than is methotrexate-y-glutamate. Methotrexate-γ-aspartate can be used in antibody-targeted liposomes and is promising for research of leukemic .
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-
-
- HY-P991641
-
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LY3012218
|
FLT3
p38 MAPK
STAT
PI3K
Akt
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Cancer
|
|
IMC-EB10 (LY3012218) is an anti-FLT3 monoclonal antibody. IMC-EB10 binds to FLT3 with high affinity (Kd = 158 pM) and blocks the binding of FLT3 ligand to FLT3 (IC50 ≈ 10 nM), thereby inhibiting MAPK, STAT5, and PI3K/Akt signaling in leukemia cells. IMC-EB10 can enhance the anti-leukemic effect of Methotrexate (HY-14519) and inhibit leukemias expressing wild-type or ITD-mutated FLT3 receptors. IMC-EB10 prolongs the survival of acute lymphoblastic leukemia (ALL) cells and primary leukemia samples and reduces engraftment in non-obese diabetic/severe combined immunodeficiency patients. IMC-EB10 is indicated for leukemia research .
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-
-
- HY-108251R
-
-
-
- HY-14519S1
-
|
|
Isotope-Labeled Compounds
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Methotrexate-d3 diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
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-
-
- HY-W769792
-
-
-
- HY-108251S
-
-
-
- HY-W654227
-
|
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Isotope-Labeled Compounds
Drug Metabolite
|
Inflammation/Immunology
|
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7-Hydroxy methotrexate-d3 (ammonium salt) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
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-
-
- HY-148657
-
|
NHS-methotrexate
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Others
|
Inflammation/Immunology
Cancer
|
|
Aminopterin N-hydroxysuccinimide ester(NHS-methotrexate) is an irreversible
Methotrexate (HY-14519) influx carrier inhibitor. Aminopterin N-hydroxysuccinimide ester can be used for the research of rheumatoid arthritis and a number of cancers (such as acute lymphoblastic leukemia) .
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-
- HY-17556B
-
|
Leucovorin calcium hydrate
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Antifolate
Endogenous Metabolite
|
Cancer
|
|
Folinic acid (Leucovorin) calcium hydrate is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease Methotrexate-induced toxicity .
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-
- HY-121256
-
|
|
Thymidylate Synthase
Antifolate
Dihydrofolate reductase (DHFR)
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Others
|
|
Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents .
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-
- HY-130569S1
-
|
|
Isotope-Labeled Compounds
Drug Metabolite
|
Metabolic Disease
|
|
7-Hydroxymethotrexate-d3 is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
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-
- HY-130569S
-
|
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Isotope-Labeled Compounds
Drug Metabolite
|
Inflammation/Immunology
Cancer
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7-Hydroxymethotrexate-d3 (sodium) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
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-
- HY-108807
-
-
- HY-137020
-
-
- HY-130569S2
-
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Isotope-Labeled Compounds
Drug Metabolite
|
Metabolic Disease
|
|
7-Hydroxymethotrexate-d3 (ammonium) is the deuterium labeled 7-Hydroxymethotrexate ammonium. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
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-
- HY-167863
-
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BW 301U isethionate; NSC 351521 isethionate
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Dihydrofolate reductase (DHFR)
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Inflammation/Immunology
|
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Piritrexim isethionate (BW 301U isethionate) is a fat-soluble dihydrofolate reductase inhibitor with activity in the treatment of severe psoriasis. Piritrexim isethionate may be as effective as methotrexate in the treatment of severe psoriasis and may have less hepatotoxicity .
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-
- HY-123098
-
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Antifolate
Bacterial
DNA/RNA Synthesis
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Cancer
|
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Tetrahydromethotrexate is a more potent folate antagonist than Methotrexate (HY-14519) in studies against certain bacteria (Streptococcus faecalis, Pediococcus erevisiae) and in animal models. Tetrahydromethotrexate is used in the research of cancer and autoimmune diseases .
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-
- HY-D2435
-
|
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Fluorescent Dye
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Inflammation/Immunology
Cancer
|
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CDDP-PEG-Cy3 is a MTX-PEG conjugate labeled with Cy3 (HY-D0822). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Methotrexate (Amethopterin; MTX) (HY-14519), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
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-
- HY-122416
-
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Lonchocarpol A; Senegalensin
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BCRP
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Metabolic Disease
Cancer
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6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin .
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-
- HY-135120
-
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methotrexate α-Methyl Ester
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Drug Intermediate
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Others
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|
Methotrexate impurity 5 (Methotrexate α-Methyl Ester) is an impurity of Methotrexate.
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-
- HY-137359
-
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methotrexate impurity 10
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Drug Intermediate
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Others
|
|
Methotrexate impurity 6 (Methotrexate impurity 10) is an impurity of Methotrexate.
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-
- HY-N1346R
-
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|
Reference Standards
Toll-like Receptor (TLR)
Apoptosis
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Inflammation/Immunology
|
|
Robinin (Standard) is the analytical standard of Robinin. This product is intended for research and analytical applications. Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect .
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-
- HY-W745173
-
-
- HY-Z15986
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- HY-Z19605
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- HY-14519C
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- HY-32179
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- HY-Z8268
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- HY-135202
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- HY-115850
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- HY-W743130
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- HY-Z8267
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- HY-137357
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NSC 305986; γ-MBMTX
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Dihydrofolate reductase (DHFR)
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Cancer
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5-Monobutyl methotrexate (NSC 305986; γ-MBMTX) is a dihydrofolate reductase (DHFR) inhibitor and esterase substrate. 5-Monobutyl methotrexate is hydrolyzed by esterases to produce methotrexate. In rhesus monkeys, 5-Monobutyl methotrexate clears more slowly from cerebrospinal fluid than from serum, and its serum protein binding rate exceeds 99%. At the same dose rate, 5-Monobutyl methotrexate achieves cerebrospinal fluid concentrations comparable to those of Methotrexate (HY-14519), and exhibits activity against Methotrexate-resistant cells (with transport defects) that is comparable to that against sensitive parental cells. 5-Monobutyl methotrexate can be used in studies related to Methotrexate-resistant tumors .
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- HY-130569A
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Drug Metabolite
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Metabolic Disease
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7-Hydroxymethotrexate sodium is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
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- HY-121714
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- HY-121702
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Drug Derivative
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Cancer
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Dihydrohomofolic acid, an analog of dihydrofolic acid (H2F), might be effective against tumor in which resistance to methotrexate (MTX) is associated with high leveIs of H2F-reductase .
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- HY-183973
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Thymidylate Synthase
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Inflammation/Immunology
Cancer
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MTXPG5 is a long-chain Methotrexate (HY-14519) metabolite and thymidylate synthase inhibitor with a Ki of 0.047 μM. MTXPG5 inhibits 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, interferes with DNA synthesis and immune cell proliferation, and inhibits pro-inflammatory cytokine production via extracellular adenosine accumulation and elevated cAMP levels. MTXPG5 can be used for the research of leukaemia and rheumatoid arthritis .
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Product Name |
Type |
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- HY-D2435
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Fluorescent Dye
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CDDP-PEG-Cy3 is a MTX-PEG conjugate labeled with Cy3 (HY-D0822). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Methotrexate (Amethopterin; MTX) (HY-14519), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
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Product Name |
Type |
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- HY-14519B
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Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate
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Biochemical Assay Reagents
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Methotrexate hydrate is a substance that affects cell growth and division. It is commonly used to fight certain diseases, especially cancer and autoimmune diseases. It works by inhibiting the process by which cells synthesize DNA.
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Product Name |
Target |
Research Area |
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- HY-W047788
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Amino Acid Derivatives
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Others
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H-Dab(Boc)-OH is an amino acid derivative with a Boc protecting group, which can be used to synthesize methotrexate (MTX) analogs with antitumor and antifolate activities .
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- HY-P1197
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Kisspeptin Receptor
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Cardiovascular Disease
Inflammation/Immunology
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Kisspeptin-10 (mouse, rat) is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10 (mouse, rat) is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound .
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- HY-P1197A
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Kisspeptin Receptor
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Cardiovascular Disease
Inflammation/Immunology
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Kisspeptin-10 (mouse, rat) TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10 (mouse, rat) TFA is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 (mouse, rat) TFA reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound .
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- HY-P11101
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Biochemical Assay Reagents
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Others
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plCSA-BP is a Placental CSA-binding peptide. plCSA-BP binds specifically to trophoblasts and not to other cell types in the placenta or to CSA-expressing cells in other tissues. plCSA-BP can guide nanoparticles for the targeted delivery of payloads (such as Indocyanine green (ICG) (HY-D0711) and Methotrexate (MTX) (HY-14519)) to the placenta, promising for placenta-specific drug delivery .
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| Cat. No. |
Product Name |
Target |
Research Area |
Image |
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- HY-P991641
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LY3012218
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FLT3
p38 MAPK
STAT
PI3K
Akt
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Cancer
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IMC-EB10 (LY3012218) is an anti-FLT3 monoclonal antibody. IMC-EB10 binds to FLT3 with high affinity (Kd = 158 pM) and blocks the binding of FLT3 ligand to FLT3 (IC50 ≈ 10 nM), thereby inhibiting MAPK, STAT5, and PI3K/Akt signaling in leukemia cells. IMC-EB10 can enhance the anti-leukemic effect of Methotrexate (HY-14519) and inhibit leukemias expressing wild-type or ITD-mutated FLT3 receptors. IMC-EB10 prolongs the survival of acute lymphoblastic leukemia (ALL) cells and primary leukemia samples and reduces engraftment in non-obese diabetic/severe combined immunodeficiency patients. IMC-EB10 is indicated for leukemia research .
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(5)
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
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- HY-14519S
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Methotrexate-d3 (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
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- HY-17556S1
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Folinic acid-d4-1 (Leucovorin-d4-1) calcium hydrate is deuterated labeled Folinic acid (HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease Methotrexate-induced toxicity.
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- HY-14519CS
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(R)-Methotrexate-d3 is the deuterium labeled (R)-Methotrexate .
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- HY-W653912A
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Leucovorin-d4 (Leucovorin-d4) calcium hydrate, >90% is a deuterated labeled Folinic acid (Leucovorin, HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .
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- HY-W745177
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Methotrexate-d3 Pentaglutamate Trifluoroacetate is the deuterium labeled Methotrexate Pentaglutamate Trifluoroacetate.
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- HY-W743645
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Methotrexate-d3 Heptaglutamate Trifluoroacetate is the deuterium labeled Methotrexate Heptaglutamate Trifluoroacetate.
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- HY-14519S1
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Methotrexate-d3 diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
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- HY-W769792
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Methotrexate-d3 Diglutamate TFA Sulfate is the deuterium labeled Methotrexate Diglutamate TFA Sulfate.
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- HY-108251S
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Methotrexate metabolite-d3 is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent .
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- HY-W654227
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7-Hydroxy methotrexate-d3 (ammonium salt) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
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- HY-130569S1
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7-Hydroxymethotrexate-d3 is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
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- HY-130569S
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7-Hydroxymethotrexate-d3 (sodium) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
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- HY-130569S2
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7-Hydroxymethotrexate-d3 (ammonium) is the deuterium labeled 7-Hydroxymethotrexate ammonium. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
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- HY-W745173
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Methotrexate-d3 Triglutamate Trifluoroacetate is the deuterium labeled Methotrexate Triglutamate Trifluoroacetate.
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- HY-W743130
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DL-Methotrexate-d3 Dipotassium Salt is the deuterium labeled DL-Methotrexate Dipotassium Salt.
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