Search Result

Isoforms Recommended:	CA IX

Results for "

CAIX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) Akt (2) Apoptosis (12) Bcl-2 Family (2) c-Met/HGFR (1) Carbonic Anhydrase (33) Caspase (4) CDK (1) DNA/RNA Synthesis (1) EGFR (1) ERK (2) Ferroptosis (2) Fluorescent Dye (1) Glutathione Peroxidase (1) HIF/HIF Prolyl-Hydroxylase (1) MDM-2/p53 (1) Mitochondrial Metabolism (1) NAMPT (1) PDGFR (1) Phosphatase (1) Phosphodiesterase (PDE) (2) Radionuclide-Drug Conjugates (RDCs) (3) Reactive Oxygen Species (ROS) (3) Small Interfering RNA (siRNA) (2) STAT (2) VEGFR (1)
By Research Areas:	Cancer (34) Inflammation/Immunology (1)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-13513

U-104 Maximum Cited Publications 8 Publications Verification SLC-0111	Carbonic Anhydrase	Cancer
U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with K_i values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model .

HY-P99023

Girentuximab 1 Publications Verification G250; cG250	Carbonic Anhydrase	Cancer
Girentuximab (G250) is a chimeric monoclonal antibody that binds carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC) .

HY-P10761

DPI-4452	Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase	Cancer
DPI-4452 is a *CAIX*-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC₅₀ for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-110243

CAIX Inhibitor S4 1 Publications Verification	Carbonic Anhydrase	Cancer
CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a K_i of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (K_i=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth .

HY-P10426

cyclo(CLLFVY)	HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC₅₀ of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers .

HY-151917

Enpp/Carbonic anhydrase-IN-2	Apoptosis Carbonic Anhydrase Phosphodiesterase (PDE)	Cancer
Enpp/Carbonic anhydrase-IN-2 (compound 1i) is a potent Enpp and carbonic anhydrase inhibitor with IC₅₀s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces Apoptosis .

HY-D2345

GZ22-4	Fluorescent Dye Carbonic Anhydrase	Cancer
GZ22-4 is a near-infrared (NIR) fluorescent probe. GZ22-4 shows high affinity for carbonic anhydrase IX (CAIX), with a K_d of 0.2 nM. GZ22-4 can be used for the research of visualize CAIX-positive tumors .

HY-174457

*STAT3/CAIX-IN-1*	STAT Carbonic Anhydrase Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Caspase Bcl-2 Family	Cancer
STAT3/CAIX-IN-1 is a dual-target inhibitor of STAT3 (K_d: 60.03 μM) and CAIX (IC₅₀: 80.45 nM). STAT3/CAIX-IN-1 induces ferroptosis by increases the levels of reactive oxygen species (ROS) and lipid peroxides. STAT3/CAIX-IN-1 inhibits cell migration, induces apoptosis, and causes cell cycle arrest in MDA-MB-231 cells. STAT3/CAIX-IN-1 can be used for the study of triple-negative breast cancer (TNBC) .

HY-146819

CAIX/CAXII-IN-1	Carbonic Anhydrase	Cancer
Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC₅₀ values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity.

HY-RS01776

CA9 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CA9 Human Pre-designed siRNA Set A contains three designed siRNAs for CA9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CA9 Human Pre-designed siRNA Set A CA9 Human Pre-designed siRNA Set A

HY-175223

CAIX-IN-4	Carbonic Anhydrase	Cancer
CAIX-IN-4 (Compound 8b) is a selective carbonic anhydrase IX (CAIX) inhibitor with an IC₅₀ value of 0.32 μM. CAIX-IN-4 is promising for research of cancers such as renal cell carcinoma .

HY-174232

EGFR/CA-IX-IN-1	EGFR Carbonic Anhydrase Caspase	Cancer
EGFR/CA-IX-IN-1 (Compound 14) is a dual inhibitor against epidermal growth factor receptor (EGFR) and carbonic anhydrase IX (CA-IX) with IC₅₀ values of 5.92 nM and 63 nM, respectively. EGFR/CA-IX-IN-1 shows strong cytotoxicity against breast cancer cells (MDA-MB-231, MCF-7) with IC₅₀ values of 5.78 μM and 8.05 μM, respectively. EGFR/CA-IX-IN-1 inhibits the catalytic activity of CA-IX, up-regulates BAX/Bcl-2, activates caspases, and arrests the cell cycle at the G1 phase. EGFR/CA-IX-IN-1 is promising for research of breast cancer .

HY-151916

Enpp/Carbonic anhydrase-IN-1	Apoptosis Carbonic Anhydrase Phosphodiesterase (PDE)	Cancer
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC₅₀s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis .

HY-173116

DOTA-XYIMSR-01	Carbonic Anhydrase	Cancer
DOTA-XYIMSR-01 is a molecular probe targeting *CAIX* that can be labeled with 177Lu for the inhibition and localization of malignant gliomas. The uptake of [177Lu] Lu-XYIMSR-01 in U87MG tumors is 6.19 % of the injected dose per gram (% ID/g), and the tumor-to-muscle uptake ratio is 20.14. In the orthotopic glioma model, combined injection with Temozolomide (HY-17364) can significantly improve the survival rate of mice and inhibit tumor growth. DOTA-XYIMSR-01 shows promise for research in the field of anti-cancer therapy .

HY-159132

CAIX/CAXII-IN-2	Carbonic Anhydrase	Cancer
CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor, with K_i values of 8.9 nM and 5.3 nM for CAIX/CAXII, respectively. CAIX/CAXII-IN-2 can be used in cancer research .

HY-169195

CAIX/CAXII-IN-3	Carbonic Anhydrase	Cancer
CAIX/CAXII-IN-3 (compound 11) is an inhibitor of *CAIX/CAXII, with an IC₅₀* value of less than 65 nM. CAIX/CAXII-IN-3 inhibits the proliferation of human melanoma cells .

HY-179022

CAIX/CDK-2-IN-1	Carbonic Anhydrase CDK Apoptosis MDM-2/p53 Caspase Bcl-2 Family	Cancer
CAIX/CDK-2-IN-1 is a dual-acting inhibitor of carbonic anhydrase IX (CA IX) and cyclin-dependent kinase-2 (CDK-2) with IC₅₀ values of 0.29 μM and 0.32 μM. The zein nanoparticls of CAIX/CDK-2-IN-1 can induce cancer cells apoptosis. CAIX/CDK-2-IN-1 can be used for the research of cancer, such as lung cancer .

HY-170893

CAIX/CAXII-IN-4	Carbonic Anhydrase	Cancer
CAIX/CAXII-IN-4 (Compound 7h) is the inhibitor for carbonic anhydrase (CA) that binds CA IX, CA XII and CA II with K_i of 1.324 μM, 0.435 μM and 3.035 μM. CAIX/CAXII-IN-4 exhibits board-spectrum antitumor efficacy, inhibits the proliferation of CNS cancer U251 with GI₅₀ of 0.361 μM .

HY-146259

hCAIX/XII-IN-4	Carbonic Anhydrase	Others
hCAIX/XII-IN-4 (compound 6c) is a potent *CAIX/XII* inhibitor with the K_i values of 4.5 nM, 23.6 nM, >10000 nM and >10000 nM for CAXII, CAIX, CAI and CAⅡ, respectively .

HY-125575

FC11409B	Carbonic Anhydrase	Cancer
FC11409B is an ureido-sulfamate carbonic anhydrase IX (CAIX) inhibitor. FC11409B inhibits proliferation and migration of breast cancer cell lines in both hypoxic (0.5% O₂) and normoxic conditions (21% O₂). FC11409B also inhibits 3D spheroid of breast cancer subtypes invasion. FC11409B is promising for research of breast and ovarian cancers .

HY-181112

CAIX-IN-17	Carbonic Anhydrase	Cancer
CAIX-IN-17 is a carbonic anhydrase IX (CAIX) inhibitor with an IC₅₀ of 61 nM and accumulates specifically in CAIX-expressing xenograft tumors. CAIX-IN-17 can be labeled with ⁶⁸Ga and acts as a CAIX-targeted PET tracer for detection of clear-cell renal cell carcinoma .

HY-146988

hCAIX/XII-IN-1	Carbonic Anhydrase Apoptosis	Cancer
hCAIX/XII-IN-1 is a potent *CAIX/XII* inhibitor with the K_I values of 0.48 µM and 0.83 µM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells .

HY-RS01913

Car9 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Car9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Car9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Car9 Mouse Pre-designed siRNA Set A Car9 Mouse Pre-designed siRNA Set A

HY-151406

hCAIX-IN-13	Apoptosis	Cancer
hCAIX-IN-13 (Pt2) is an inhibitor of *CAIX* (arbonic anhydrase IX) with an IC₅₀ value of 6.57 μM. hCAIX-IN-13 inhibits growth of cancer cells and induces cell apoptosis, it can be used for the research of cancer .

HY-163691

Antitumor agent-163	Carbonic Anhydrase	Cancer
Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX). Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA). Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC₅₀ is 0.2 and 0.05 μM for A549 and U87MG). Antitumor agent-163 exhibits antitumor efficacy in mouse model .

HY-146254

hCAIX-IN-12	Carbonic Anhydrase Apoptosis Reactive Oxygen Species (ROS)	Cancer
hCAIX-IN-12 is a potent hCAIX inhibitor with IC₅₀ values of 0.74, 10.78 μM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer (CRC) .

HY-157139

ALP/Carbonic anhydrase-IN-1	Carbonic Anhydrase Phosphatase	Inflammation/Immunology
ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual carbonic anhydrase (CA) and alkaline phosphatase (ALP) inhibitor. ALP/Carbonic anhydrase-IN-1 shows IC₅₀ values of 0.44 µM, 1.61 µM, 0.51 µM, and 0.107 µM for CA-II, CA-IX, CA-XII, and ALP, respectively .

HY-147722

hCAIX-IN-8	Carbonic Anhydrase	Cancer
hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC₅₀s of 1.99, 0.024, 1.10 μM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential .

HY-178475

CA IX/GPX4-IN-1	Carbonic Anhydrase Glutathione Peroxidase Ferroptosis	Cancer
CA IX/GPX4-IN-1 (Compound 22abcb) is a dual targeted inhibitor of CA IX and GPX4 activity. CA IX/GPX4-IN-1 can effectively kill SUM159PT cells (IC₅₀ = 416 nM) by inducing iron death under hypoxic conditions. CA IX/GPX4-IN-1 has an IC₅₀ of 663 nM to CA IX in SUM159PT-CAIX-FL cells. CA IX/GPX4-IN-1 can significantly inhibit tumor growth and can be reversed by ferroptosis inhibitors. CA IX/GPX4-IN-1 can be used for research on breast cancer and other cancers .

HY-179034

CAIX/XII-IN-16	Carbonic Anhydrase c-Met/HGFR Apoptosis	Cancer
CAIX/XII-IN-16 (Compound 5d) is a selective inhibitor of CA IX/XII and c-Met. CAIX/XII-IN-16‘s K_i values for hCA IX, hCA XII and CA I are 10.6, 31.8 and 2361 nM respectively, and its IC₅₀ value for c-Met is 0.49 μM. CAIX/XII-IN-16 exhibits significantly enhanced cytotoxicity against colon cancer cells under hypoxic conditions. CAIX/XII-IN-16 causes cell cycle arrest and induces apoptosis (apoptosis). CAIX/XII-IN-16 significantly enhances the efficacy of Oxaliplatin (HY-17371) and 5-Fluorouracil (HY-90006). CAIX/XII-IN-16 can be used for studies on chemotherapy resistance related to hypoxia .

HY-183590

CAIX/XII-IN-17	Carbonic Anhydrase Apoptosis	Cancer
CAIX/XII-IN-17 is a selective human carbonic anhydrase IX/XII (CA IX/XII) inhibitor with K_i values of 25.1 nM (hCA IX) and 35.2 nM (hCA XII). CAIX/XII-IN-17 induces apoptosis in pancreatic cancer cells. CAIX/XII-IN-17 can be used for the research of breast cancer, pancreatic cancer .

HY-183591

CAIX/XII-IN-18	Carbonic Anhydrase Apoptosis	Cancer
CAIX/XII-IN-18 is a selective human carbonic anhydrase IX/XII (CA IX/XII) inhibitor with K_i values of 28.1 nM (hCA IX) and 11.6 nM (hCA XII). CAIX/XII-IN-18 induces apoptosis in breast cancer cells. CAIX/XII-IN-18 can be used for the research of breast cancer, pancreatic cancer .

HY-183580

CAIX/CAXII-IN prodrug-1		Cancer
CAIX/CAXII-IN prodrug-1 is a subtype-dependent prodrug inhibitor of carbonic anhydrase IX and XII (CAIX/CAXII). CAIX/CAXII-IN prodrug-1 itself shows no activity against carbonic anhydrases, and after hydrolysis, it exhibits K_i values of 54 nM and 62 nM against hCA IX and hCA XII, respectively. CAIX/CAXII-IN prodrug-1 exerts antiproliferative activity against cancer cells and induces cell apoptosis (apoptosis) via the endogenous mitochondrial pathway. CAIX/CAXII-IN prodrug-1 can be used in the research of breast cancer, colorectal adenocarcinoma and prostate cancer .

HY-181350

CAIX/XII/NAMPT-IN-1	Carbonic Anhydrase NAMPT Apoptosis Reactive Oxygen Species (ROS) ERK Akt DNA/RNA Synthesis Mitochondrial Metabolism	Cancer
CAIX/XII/NAMPT-IN-1 is a triple inhibitor of carbonic anhydrase IX/XII and nicotinamide phosphoribosyltransferase (NAMPT) with a hCA IX K_i of 78.1 nM, hCA XII K_i of 64.4 nM, and hNAMPT IC₅₀ of 168 nM. CAIX/XII/NAMPT-IN-1 induces apoptosis, ROS accumulation, suppresses ERK/AKT signaling, inhibits DNA synthesis, and causes mitochondrial dysfunction. CAIX/XII/NAMPT-IN-1 exerts antiproliferative effects against multiple cancer cells under normoxic and hypoxic conditions. CAIX/XII/NAMPT-IN-1 can be used for the research of cancer, such as renal carcinoma, glioblastoma and colorectal cancer .

HY-181587

*PDGFRA/CAIX/XII-IN-1*	PDGFR Carbonic Anhydrase STAT Akt ERK Apoptosis Caspase	Cancer
PDGFRA/CAIX/XII-IN-1 is an inhibitor of PDGFRA, CA IX and CA XII, with an IC₅₀ of 20 nM against PDGFRA, a K_i of 93.3 nM against CA IX, and a K_i of 80.0 nM against CA XII. PDGFRA/CAIX/XII-IN-1 binds to the ATP-binding pocket of PDGFRA and blocks the downstream STAT3, AKT and ERK1/2 signaling pathways. PDGFRA/CAIX/XII-IN-1 induces G0/G1 cell cycle arrest and endogenous apoptosis (Apoptosis), including cleavage of PARP-1, caspase-9 and caspase-3, activation of caspase 3/7, and down-regulation of Mcl-1. PDGFRA/CAIX/XII-IN-1 exhibits antiproliferative activity in eosinophilic leukemia cells. PDGFRA/CAIX/XII-IN-1 can be used for the research of leukemia .

HY-183374

NYM074	Carbonic Anhydrase Radionuclide-Drug Conjugates (RDCs)	Cancer
NYM074 is a carbonic anhydrase IX (CAIX) ligand. NYM074 binds specifically to human *CAIX* to enable targeted radionuclide delivery. NYM074 supports dual radiolabeling with ⁶⁸Ga for positron emission tomography (PET) imaging and ¹⁷⁷Lu for radionuclide applications. NYM074 can be used for the research of clear cell renal cell carcinoma .

HY-P11737

IPM-N001	Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase	Cancer
IPM-N001 is a carbonic anhydrase IX (CAIX) ligand with a K_d value of <0.0337 nM for hCAIX. When radio-conjugated with ⁶⁸Ga, IPM-N001 serves as a CAIX-targeted radionuclide tracer. [ ⁶⁸Ga]Ga-IPM-N001 exhibits excellent tumor uptake and significantly improves the tumor-to-background ratio in PET/CT imaging studies using OS-RC-2 tumor-bearing mice. IPM-N001 can be used for the research of clear cell renal cell carcinoma .

HY-P992322

BAY-79-4620 Antibody	ADC Antibody Carbonic Anhydrase	Cancer
BAY-79-4620 Antibody is a potent and selective *CAIX* antibody with a human CAIX K_d of 3.6 nM. BAY-79-4620 Antibody yields antibody-drug conjugate (ADC) through conjugating with Monomethyl auristatin E (HY-15162) via a self-immolative enzyme-cleavable linker. BAY-79-4620 Antibody can be used for the research of cervical carcinoma, non-small cell lung carcinoma, breast carcinoma, pancreatic carcinoma, gastric carcinoma, prostate carcinoma .

GZ22-4	Fluorescent Dyes
GZ22-4 is a near-infrared (NIR) fluorescent probe. GZ22-4 shows high affinity for carbonic anhydrase IX (CAIX), with a K_d of 0.2 nM. GZ22-4 can be used for the research of visualize CAIX-positive tumors .

Art. -Nr.	Produktname	Target	Research Area

HY-P10761

DPI-4452	Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase	Cancer
DPI-4452 is a *CAIX*-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC₅₀ for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P10426

cyclo(CLLFVY)	HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC₅₀ of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers .

HY-P11737

IPM-N001	Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase	Cancer
IPM-N001 is a carbonic anhydrase IX (CAIX) ligand with a K_d value of <0.0337 nM for hCAIX. When radio-conjugated with ⁶⁸Ga, IPM-N001 serves as a CAIX-targeted radionuclide tracer. [ ⁶⁸Ga]Ga-IPM-N001 exhibits excellent tumor uptake and significantly improves the tumor-to-background ratio in PET/CT imaging studies using OS-RC-2 tumor-bearing mice. IPM-N001 can be used for the research of clear cell renal cell carcinoma .

Art. -Nr.	Produktname	Target	Research Area	Image

HY-P99023

Girentuximab 1 Publications Verification G250; cG250	Carbonic Anhydrase	Cancer
Girentuximab (G250) is a chimeric monoclonal antibody that binds carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC) .

HY-P992322

BAY-79-4620 Antibody	ADC Antibody Carbonic Anhydrase	Cancer
BAY-79-4620 Antibody is a potent and selective *CAIX* antibody with a human CAIX K_d of 3.6 nM. BAY-79-4620 Antibody yields antibody-drug conjugate (ADC) through conjugating with Monomethyl auristatin E (HY-15162) via a self-immolative enzyme-cleavable linker. BAY-79-4620 Antibody can be used for the research of cervical carcinoma, non-small cell lung carcinoma, breast carcinoma, pancreatic carcinoma, gastric carcinoma, prostate carcinoma .

Recombinant Proteins Recommended:

Carbonic Anhydrase 9 (CA IX)

Species:	Human (6) Mouse (1) Cynomolgus (2) Canine (2)
Tag:	His (8) Avi (4) Fc (3)
Source:	HEK293 (11)

Art. -Nr.	Compare	Produktname	Species	Source	Image

HY-P78563

	Carbonic Anhydrase 9 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) CAIX; CA9; CA-IX; G250; MN; P54; 58N; pMW1	Cynomolgus	HEK293
	Carbonic Anhydrase 9 Protein catalyzes the reversible hydration of carbon dioxide, essential for converting it to bicarbonate ions and protons, and vice versa. This enzymatic activity is crucial in physiological processes like acid-base balance regulation, respiration, and cellular pH homeostasis. Carbonic Anhydrase 9 Protein is vital for carbon dioxide transport and metabolism, contributing to overall regulation of its levels in the body. Carbonic Anhydrase 9 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Carbonic Anhydrase 9 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is 361 a.a., with molecular weight of 50-55 kDa.

HY-P78396

	Carbonic Anhydrase 9 Protein, Human (HEK293, His-Avi) CA9; CAIX; CA-IX; EC 4.2.1.1; G250; MN; P54/58N; PMW1; RCC	Human	HEK293
	The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P700882

	Carbonic Anhydrase 9 Protein, Cynomolgus (HEK293, His) CA9; CAIX; CA-IX; EC 4.2.1.1; G250; MN; P54/58N; PMW1; RCC	Cynomolgus	HEK293
	Carbonic Anhydrase 9 Protein catalyzes the reversible hydration of carbon dioxide, essential for converting it to bicarbonate ions and protons, and vice versa. This enzymatic activity is crucial in physiological processes like acid-base balance regulation, respiration, and cellular pH homeostasis. Carbonic Anhydrase 9 Protein is vital for carbon dioxide transport and metabolism, contributing to overall regulation of its levels in the body. Carbonic Anhydrase 9 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77585

	Carbonic Anhydrase 9 Protein, Mouse (HEK293, His) CA9; CAIX; CA-IX; EC 4.2.1.1; G250; MN; P54/58N; PMW1; RCC	Mouse	HEK293
	The Carbonic Anhydrase 9 protein is responsible for catalyzing the interconversion between carbon dioxide and water, as well as facilitating the conversion of carbonic acid into its dissociated ions, namely bicarbonate and hydrogen ions. Carbonic Anhydrase 9 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75454

	Carbonic Anhydrase 9 Protein, Canine (HEK293, His) Carbonic anhydrase 9; CA-IX; P54/58N; pMW1; CA9; G250; MN	Canine	HEK293
	The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Canine (HEK293, His) is the recombinant canine-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75455

	Carbonic Anhydrase 9 Protein, Canine (HEK293, hFc) Carbonic anhydrase 9; CA-IX; P54/58N; pMW1; CA9; G250; MN	Canine	HEK293
	The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Canine (HEK293, hFc) is the recombinant canine-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72863

	Carbonic Anhydrase 9 Protein, Human (HEK293, Fc) Carbonic anhydrase 9; CA-IX; P54/58N; pMW1; CA9; G250; MN	Human	HEK293
	The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Human (HEK293, Fc) is the recombinant human-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704987

	Carbonic Anhydrase 9 Protein, Human (Biotinylated, HEK293, Fc-Avi) CA9; CA-IX; Carbonic Anhydrase IX; Carbonate dehydratase IX; G250; MN; P54/58N; RCC; RCC-associated protein G250	Human	HEK293

HY-P72348

	Carbonic Anhydrase 9 Protein, Human (Biotinylated, HEK293, Avi-His) CA9; CA-IX; Carbonic Anhydrase IX; Carbonate dehydratase IX; G250; MN; P54/58N; RCC; RCC-associated protein G250	Human	HEK293
	The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P70064

	Carbonic Anhydrase 9 Protein, Human (HEK293, His) rHuCarbonic Anhydrase 9/CA9, His; CA9; CA-IX; Carbonic Anhydrase IX; Carbonate dehydratase IX; G250; MN; P54/58N; RCC; RCC-associated protein G250	Human	HEK293
	The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). Carbonic Anhydrase 9 Protein, Human (HEK293, His) is the recombinant human-derived Carbonic Anhydrase 9 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704425

	FITC-Labeled Carbonic Anhydrase 9 Protein, Human (HEK293, His) rHuCarbonic Anhydrase 9/CA9, His; CA9; CA-IX; Carbonic Anhydrase IX; Carbonate dehydratase IX; G250; MN; P54/58N; RCC; RCC-associated protein G250	Human	HEK293
	The carbonic anhydrase 9 (CA9) protein plays a crucial role as a catalyst in the conversion of carbon dioxide and water. It promotes the formation of bicarbonate and hydrogen ions (dissociated ions of carbonic acid). FITC-Labeled Carbonic Anhydrase 9 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled Carbonic Anhydrase 9 protein, expressed by HEK293, with C-His labeled tag.

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Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / Auf Lager - + In den Warenkorb hinzufügen Angebot einholen

Host:	Mouse (7) Rabbit (2)
Reactivity:	Human (9) Rat (1) Mouse (1)
Application:	IHC-P (8) ICC/IF (2) IF-Tissue (2) IP (2) IHC-F (2) WB (5) FC (4) ELISA (5)
Isotype:	IgG (6) IgG1 (2)
Conjugation:	Non-conjugated (9) Biotin (3)
Clonality:	Monoclonal (7) Recombinant (1)
Modification:	Unmodified (7)

Art. -Nr.	Compare	Produktname	Application	Reactivity	Image

HY-P84620

	CA9 Antibody (YA4317) MN; CAIX; CA9	WB, IHC-P, FC, ELISA	Human
	CA9 Antibody (YA4317) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CA9.

HY-P84620A

	CA9 Antibody (YA4317)(PBS only) MN; CAIX; CA9	WB, IHC-P, FC, ELISA	Human
	CA9 Antibody (YA4317) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CA9.

HY-P86587

	CA9 Antibody (YA6279) G250; MN; Carbonic anhydrase 9; Carbonate dehydratase IX; Carbonic anhydrase IX; CA-IX; CAIX; Membrane antigen MN; P54/58N; Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; pMW1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CA9 Antibody (YA6279) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CA9.

HY-P86005

	CA9 Antibody (YA5697) G250; MN; Carbonic anhydrase 9; Carbonate dehydratase IX; Carbonic anhydrase IX; CA-IX; CAIX; Membrane antigen MN; P54/58N; Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; pMW1	IHC-P, ELISA	Human
	CA9 Antibody (YA5697) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to CA9.

HY-P82698

	CA9 Antibody (YA2443) CA9; G250; MN; Carbonic anhydrase 9; Carbonate dehydratase IX; Carbonic anhydrase IX; CA-IX; CAIX; Membrane antigen MN; P54/58N; Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; pMW1	WB, IHC-P, FC	Human
	CA9 Antibody (YA2443) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to CA9.

HY-P85663

	CA9 Antibody (YA5355) CA9; G250; MN; Carbonic anhydrase 9; Carbonate dehydratase IX; Carbonic anhydrase IX; CA-IX; CAIX; Membrane antigen MN; P54/58N; Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; pMW1	ICC/IF, WB, IHC-P, IP	Human
	CA9 Antibody (YA5355) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CA9.

HY-P86721

	CA9 Antibody (YA6413) CA IX; CA-IX; Carbonic anhydrase 9; CAH9_HUMAN; CAIX; Carbonate dehydratase IX; Carbonic anhydrase IX; Carbonic dehydratase; G250; Membrane antigen MN; MN; P54/58N; P54/58N; pMW1; RCC associated protein G250; RCC-associated antigen G250; Renal cell carcinoma associated antigen G250; Renal cell carcinoma-associated antigen G250.	IHC-P, IHC-F, IF-Tissue	Human
	CA9 Antibody (YA6413) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to CA9.

HY-P86721A

	CA9 Antibody (YA6413)(PBS only) CA IX; CA-IX; Carbonic anhydrase 9; CAH9_HUMAN; CAIX; Carbonate dehydratase IX; Carbonic anhydrase IX; Carbonic dehydratase; G250; Membrane antigen MN; MN; P54/58N; P54/58N; pMW1; RCC associated protein G250; RCC-associated antigen G250; Renal cell carcinoma associated antigen G250; Renal cell carcinoma-associated antigen G250.	IHC-P, IHC-F, IF-Tissue	Human
	CA9 Antibody (YA6413) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to CA9.

HY-P81623

	CA9 Antibody (YA1368) CA9; G250; MN; Carbonic anhydrase 9; Carbonate dehydratase IX; Carbonic anhydrase IX; CA-IX; CAIX; Membrane antigen MN; P54/58N; Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; pMW1	FC, ELISA	Human
	CA9 Antibody (YA1368) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CA9.

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Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / Auf Lager - + In den Warenkorb hinzufügen Angebot einholen

Art. -Nr.	Produktname		Classification

HY-159132

CAIX/CAXII-IN-2		Azide
CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor, with K_i values of 8.9 nM and 5.3 nM for CAIX/CAXII, respectively. CAIX/CAXII-IN-2 can be used in cancer research .

HY-178475

CA IX/GPX4-IN-1		Alkynes
CA IX/GPX4-IN-1 (Compound 22abcb) is a dual targeted inhibitor of CA IX and GPX4 activity. CA IX/GPX4-IN-1 can effectively kill SUM159PT cells (IC₅₀ = 416 nM) by inducing iron death under hypoxic conditions. CA IX/GPX4-IN-1 has an IC₅₀ of 663 nM to CA IX in SUM159PT-CAIX-FL cells. CA IX/GPX4-IN-1 can significantly inhibit tumor growth and can be reversed by ferroptosis inhibitors. CA IX/GPX4-IN-1 can be used for research on breast cancer and other cancers .

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