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Cat. No.: HY-146988

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hCAIX/XII-IN-1

hCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the K_I values of 0.48 µM and 0.83 µM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells.

For research use only. We do not sell to patients.

CAS No.: 3033040-76-2
Formula: C₁₉H₁₁NO₅S₂
Molecular Weight:397.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

hCAIX/XII-IN-1 Chemical Structure

CAS No.: 3033040-76-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

CA IX

All Carbonic Anhydrase Isoforms :

In Vitro

hCAIX/XII-IN-1 (compound 11a) (3.125, 6.25, 12.5, 25, 50 µM, 48 h) shows antiproliferative activity with an IC₅₀ value of 0.48 µM in MCF-7 cells^[1].
hCAIX/XII-IN-1 (0.48 µM; 24 h) increases the cell populations of Sub-G1 phase^[1].
hCAIX/XII-IN-1 (0.48 µM) induces apoptosis in MCF-7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7 cells
Concentration:

3.125, 6.25, 12.5, 25, 50 µM
Incubation Time:

48 h
Result:

Showed antiproliferative activity with an IC₅₀ value of 0.48 µM in MCF-7 cells.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

0.48 µM
Incubation Time:

24 h
Result:

Significantly increased the cell populations of Sub-G1 phase.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

0.48 µM
Incubation Time:
Result:

Induced apoptosis in MCF-7 cells.

Chemical Information

CAS No. 3033040-76-2
Molecular Weight 397.42
Formula C₁₉H₁₁NO₅S₂
SMILES

O=C(C1=CC2=C(OC1=O)C=CC=C2)CN3C(S/C(C3=O)=C\C4=CC=CS4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Eldehna WM, et al. Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. J Enzyme Inhib Med Chem. 2022; 37(1):531-541.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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hCAIX/XII-IN-1

All Carbonic Anhydrase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

hCAIX/XII-IN-1 Related Classifications

HY-146988 Related Classifications