hCAIX/XII-IN-1 

hCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the K_I values of 0.48 µM and 0.83 µM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells^[1].

K_I: 0.48 µM (CAIX); 0.83 µM (CAXII)^[1]

hCAIX/XII-IN-1 (compound 11a) (3.125, 6.25, 12.5, 25, 50 µM, 48 h) shows antiproliferative activity with an IC₅₀ value of 0.48 µM in MCF-7 cells^[1].
hCAIX/XII-IN-1 (0.48 µM; 24 h) increases the cell populations of Sub-G1 phase^[1].
hCAIX/XII-IN-1 (0.48 µM) induces apoptosis in MCF-7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

397.42

C₁₉H₁₁NO₅S₂

O=C(C1=CC2=C(OC1=O)C=CC=C2)CN3C(S/C(C3=O)=C\C4=CC=CS4)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Eldehna WM, et al. Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. J Enzyme Inhib Med Chem. 2022; 37(1):531-541.