IPM-N001 

IPM-N001 is a carbonic anhydrase IX (CAIX) ligand with a K_d value of <0.0337 nM for hCAIX. When radio-conjugated with ⁶⁸Ga, IPM-N001 serves as a CAIX-targeted radionuclide tracer. [⁶⁸Ga]Ga-IPM-N001 exhibits excellent tumor uptake and significantly improves the tumor-to-background ratio in PET/CT imaging studies using OS-RC-2 tumor-bearing mice. IPM-N001 can be used for the research of clear cell renal cell carcinoma^[1].

IPM-N001 exhibits high binding affinity for purified hCAIX, with a K_d value of <0.0337 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[⁶⁸Ga]Ga-IPM-N001 (3.7-7.4 MBq; intravenous injection; single dose) achieves highly specific tumor uptake targeting clear cell renal cell carcinoma (ccRCC) in male Balb/c-nu mice, with a static PET/CT detection value of 8.9 ± 1.1 %ID/g and an ex vivo biodistribution detection value of 27.61 ± 7.48 %ID/g^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2258.51

C₉₉H₁₄₀N₂₄O₃₁S₃

NC([C@@H](NC([C@H](CO)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H]([C@@H](C)O)CC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H]3N(C([C@H](CCC(O)=O)N4)=O)CCC3)=O)=O)CC5=CC=CC(NC(CCCS(N)(=O)=O)=O)=C5)=O)=O)=O)=O)=O)CSCC6=CC(CSC[C@H](NC([C@H](CCC(NCCCN7C=CN=C7[N+]([O-])=O)=O)NC(CN8CCN(C(CN9CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC9)=O)CC8)=O)=O)C4=O)=CC=C6)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Niu X, et al. Nitroimidazole-Containing [⁶⁸Ga]Ga-IPM-N001 as a New CAIX-Targeting Radionuclide Tracer. J Med Chem. 2026;69(6):7474-7487.