1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. hCAIX-IN-8

hCAIX-IN-8 

Cat. No.: HY-147722
Handling Instructions

hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 µM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential.

For research use only. We do not sell to patients.

hCAIX-IN-8 Chemical Structure

hCAIX-IN-8 Chemical Structure

CAS No. : 2414633-40-0

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Description

hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 µM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential[1].

IC50 & Target

IC50: 1.99 µM (CAII); 0.024 (CAIX), 1.10 µM (CAVA)[1]

In Vitro

hCAIX-IN-8 (compound 7i) shows anti-proliferation activity with IC50是of 8.44, 11.22 µM for HT29, HepG2 cells, respectively[1].
hCAIX-IN-8 induces apoptosis in 24.44% and 19.22% of HT29 and HepG2 cells, respectivelysup>[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.35

Formula

C19H16N4O6

CAS No.
SMILES

COC1=CC(/C=C/C(O)=O)=CC=C1OCC2=CN(N=N2)C3=CC([N+]([O-])=O)=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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hCAIX-IN-8
Cat. No.:
HY-147722
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