hCAIX-IN-8 

hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC₅₀s of 1.99, 0.024, 1.10 µM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential^[1].

IC₅₀: 1.99 µM (CAII); 0.024 (CAIX), 1.10 µM (CAVA)^[1]

hCAIX-IN-8 (compound 7i) shows anti-proliferation activity with IC₅₀是of 8.44, 11.22 µM for HT29, HepG2 cells, respectively^[1].
hCAIX-IN-8 induces apoptosis in 24.44% and 19.22% of HT29 and HepG2 cells, respectivelysup>[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

396.35

C₁₉H₁₆N₄O₆

2414633-40-0

COC1=CC(/C=C/C(O)=O)=CC=C1OCC2=CN(N=N2)C3=CC([N+]([O-])=O)=CC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Aneja B,et al. Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX. Bioorg Med Chem. 2020 May 1;28(9):115424.  [Content Brief]