hCAIX-IN-8
hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 μM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential.
For research use only. We do not sell to patients.
- CAS No.: 2414633-40-0
- Formula: C19H16N4O6
- Molecular Weight:396.35
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
CA IX |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BT-549 | IC50 |
9.4 μg/mL
Compound: 162
|
Antiproliferative activity against human BT-549 cells
Antiproliferative activity against human BT-549 cells
|
[PMID: 38308950] |
| HepG2 | IC50 |
11.22 μM
Compound: 7i
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 32209296] |
| HT-29 | IC50 |
8.44 μM
Compound: 7i
|
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 32209296] |
| KB | IC50 |
8 μg/mL
Compound: 162
|
Antiproliferative activity against human KB cells
Antiproliferative activity against human KB cells
|
[PMID: 38308950] |
| SK-MEL | IC50 |
9 μg/mL
Compound: 162
|
Antiproliferative activity against human SK-MEL cells
Antiproliferative activity against human SK-MEL cells
|
[PMID: 38308950] |
| SK-OV-3 | IC50 |
>10 μg/mL
Compound: 162
|
Antiproliferative activity against human SK-OV-3 cells
Antiproliferative activity against human SK-OV-3 cells
|
[PMID: 38308950] |
hCAIX-IN-8 (compound 7i) shows anti-proliferation activity with IC50 of 8.44, 11.22 μM for HT29, HepG2 cells, respectively[1].
hCAIX-IN-8 induces apoptosis in 24.44% and 19.22% of HT29 and HepG2 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2414633-40-0
-
Molecular Weight 396.35
-
Formula C19H16N4O6
-
SMILES
COC1=CC(/C=C/C(O)=O)=CC=C1OCC2=CN(N=N2)C3=CC([N+]([O-])=O)=CC=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAIX-IN-8 Related Classifications
HY-147722 Related Classifications
Powered by Bioz