2414633-40-0
Chemical Structure
hCAIX-IN-8
- CAS No.: 2414633-40-0
- Formula:C19H16N4O6
- Molecular Weight:396.35
IUPAC Name: (E)-3-(3-methoxy-4-((1-(3-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acrylic acid
InChIKey: SRKGDLYYDIWTBU-SOFGYWHQSA-N
SMILES: COC1=CC(/C=C/C(O)=O)=CC=C1OCC2=CN(N=N2)C3=CC([N+]([O-])=O)=CC=C3
Biological Activity: hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 μM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential[1].
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hCAIX-IN-8 | hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 μM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential. | |||||||||||||||||||||
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Keywords
