hCAIX-IN-12
hCAIX-IN-12 is a potent hCAIX inhibitor with IC50 values of 0.74, 10.78 μM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer (CRC) .
For research use only. We do not sell to patients.
- CAS No.: 2414598-85-7
- Formula: C18H14N4O3S2
- Molecular Weight:398.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CA IX |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
6 μM
Compound: 38
|
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 34530384] |
| HCT-116 | IC50 |
6 μM
Compound: 85; OX27
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Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability
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[PMID: 38308950] |
hCAIX-IN-12 (compound OX27) shows antiproliferative effect with IC50s of 6.0 μM for HCT-116 cells[1].
hCAIX-IN-12 decreases the expression of CAIX in HCT-116 cells and inhibits the expression of CAIX more pronouncedly in hypoxic conditions[1].
hCAIX-IN-12 (0-50 μM; 0-48 h) inhibits the colony formation in a dose-dependent manner and 7 inhibits the migration of HCT-116 cells[1].
hCAIX-IN-12 (6.0 μM; 48 h) induces apoptosis in HCT-116 cells[1].
hCAIX-IN-12 (6.0 μM; 24,48 h) increases in the levels of ROS in HCT-116 cells[1].
hCAIX-IN-12 causes depletion of HCT-116 cells in the G0/G1 (P2 65.21%) phase with an increase in the accumulation of cells in G2/M (P4 18.95%) phase[1].
hCAIX-IN-12 has high binding affinity for CAIX and substantial affinity for HSA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2414598-85-7
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Molecular Weight 398.46
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Formula C18H14N4O3S2
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SMILES
O=S(C1=CC=C(N)C=C1)(NC2=C(C3=NC(C4=CC=CC=C4)=NO3)SC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAIX-IN-12 Related Classifications
HY-146254 Related Classifications
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