hCAIX-IN-13
hCAIX-IN-13 (Pt2) is an inhibitor of CAIX (arbonic anhydrase IX) with an IC50 value of 6.57 μM. hCAIX-IN-13 inhibits growth of cancer cells and induces cell apoptosis, it can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2813334-66-4
- Formula: C37H33F3N6O7PtS2
- Molecular Weight:989.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 6.57 μM (CAIX)[1]
hCAIX-IN-13 (10 and 20 μM; 24 h) effectively attenuates extracellular acidification through the inhibited activity of the cellular CAIX expression[1]. hCAIX-IN-13 (20 and 40 μM; 24 h) affects CAIX expression[1]. hCAIX-IN-13 (0-200 μM; 24 h) shows high cytotoxicity to cancer cell lines[1]. hCAIX-IN-13 (5-15 μM; 24 h) promotes the production of cellular ROS[1]. hCAIX-IN-13 (5-20 μM; 48 h) induces cell apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cell line
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Concentration:20 and 40 μM
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Incubation Time:24 hours
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Result:Dose-dependently inhibited the expression level of cellular CAIX.
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Cell Line:Hela, A549, MDA-MB 231, HLF and LO2 cell lines
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Concentration:0-200 μM
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Incubation Time:48 hours
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Result:Showed cytotoxicity to Hela, A549, MDA-MB 231, normal cell HLF and normal cell LO2 with IC50s of 31.64, 30.45, 12.67, 21.64 and ＞100 μM, respectively.
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Cell Line:MDA-MB-231 cell line
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Concentration:5-20 μM
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Incubation Time:48 hours
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Result:Dose-dependently induced the early apoptotic stage.
Chemical Information
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CAS No. 2813334-66-4
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Molecular Weight 989.90
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Formula C37H33F3N6O7PtS2
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SMILES
O=C(CCCC(NCCC1=CC=C(S(=O)(N)=O)C=C1)=O)NC2=CC3=CC=C[N]4=C3C5=[N]([Pt+2]46[C-]7=C(C8=[N]6C=CC=C8)C=CC=C7)C=CC=C52.FC(F)(S(=O)([O-])=O)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAIX-IN-13 Related Classifications
HY-151406 Related Classifications
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