2. Apoptosis
  3. Apoptosis
  4. hCAIX-IN-13

hCAIX-IN-13 (Pt2) is an inhibitor of CAIX (arbonic anhydrase IX) with an IC50 value of 6.57 μM. hCAIX-IN-13 inhibits growth of cancer cells and induces cell apoptosis, it can be used for the research of cancer.

For research use only. We do not sell to patients.

hCAIX-IN-13 Chemical Structure

hCAIX-IN-13 Chemical Structure

CAS No. : 2813334-66-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

hCAIX-IN-13 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

hCAIX-IN-13 (Pt2) is an inhibitor of CAIX (arbonic anhydrase IX) with an IC50 value of 6.57 μM. hCAIX-IN-13 inhibits growth of cancer cells and induces cell apoptosis, it can be used for the research of cancer[1].

IC50 & Target

IC50: 6.57 μM (CAIX)[1]
In Vitro

hCAIX-IN-13 (10 and 20 μM; 24 h) effectively attenuates extracellular acidification through the inhibited activity of the cellular CAIX expression[1].
hCAIX-IN-13 (20 and 40 μM; 24 h) affects CAIX expression[1].
hCAIX-IN-13 (0-200 μM; 24 h) shows high cytotoxicity to cancer cell lines[1].
hCAIX-IN-13 (5-15 μM; 24 h) promotes the production of cellular ROS[1].
hCAIX-IN-13 (5-20 μM; 48 h) induces cell apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

hCAIX-IN-13 Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cell line
Concentration: 20 and 40 μM
Incubation Time: 24 hours
Result: Dose-dependently inhibited the expression level of cellular CAIX.

Cell Cytotoxicity Assay[1]

Cell Line: Hela, A549, MDA-MB 231, HLF and LO2 cell lines
Concentration: 0-200 μM
Incubation Time: 48 hours
Result: Showed cytotoxicity to Hela, A549, MDA-MB 231, normal cell HLF and normal cell LO2 with IC50s of 31.64, 30.45, 12.67, 21.64 and ＞100 μM, respectively.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cell line
Concentration: 5-20 μM
Incubation Time: 48 hours
Result: Dose-dependently induced the early apoptotic stage.
Molecular Weight

989.90

Formula

C37H33F3N6O7PtS2
CAS No.
SMILES

O=C(CCCC(NCCC1=CC=C(S(=O)(N)=O)C=C1)=O)NC2=CC3=CC=C[N]4=C3C5=[N]([Pt+2]46[C-]7=C(C8=[N]6C=CC=C8)C=CC=C7)C=CC=C52.FC(F)(S(=O)([O-])=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

hCAIX-IN-13 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX-IN-132813334-66-4Apoptosiscisplatinacidificationcellular environmentNIRcomplexlysosomeHelaROSMDA-MB 231apoptosisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
hCAIX-IN-13
Cat. No.:
HY-151406
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.