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Cat. No.: HY-183580

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CAIX/CAXII-IN prodrug-1

CAIX/CAXII-IN prodrug-1 is a subtype-dependent prodrug inhibitor of carbonic anhydrase IX and XII (CAIX/CAXII). CAIX/CAXII-IN prodrug-1 itself shows no activity against carbonic anhydrases, and after hydrolysis, it exhibits K_i values of 54 nM and 62 nM against hCA IX and hCA XII, respectively. CAIX/CAXII-IN prodrug-1 exerts antiproliferative activity against cancer cells and induces cell apoptosis (apoptosis) via the endogenous mitochondrial pathway. CAIX/CAXII-IN prodrug-1 can be used in the research of breast cancer, colorectal adenocarcinoma and prostate cancer.

For research use only. We do not sell to patients.

Formula: C₁₀H₁₁O₄P
Molecular Weight:226.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CAIX/CAXII-IN prodrug-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

CAIX/CAXII-IN prodrug-1 (Compound 10) (1 mM; 15 min-6 h) undergoes subtype-dependent phosphate ester hydrolysis, a process primarily mediated by recombinant human hCA IX and hCA XII, forming hydrolytic products after 6 h of incubation^[1].
CAIX/CAXII-IN prodrug-1 inhibits the proliferation of human MCF-7, MDA-MB-231, HCT116 and PC-3 cancer cell lines, with IC₅₀ values ranging from 16.1, 4.17, 2.02 to 1.83 μM, respectively, and exhibits the strongest activity against HCT116 and PC-3 cells^[1].
CAIX/CAXII-IN prodrug-1 (1.83 μM) activates the intrinsic mitochondrial apoptotic pathway in PC-3 cells by upregulating Bax, p53, caspase-3, caspase-9 and cytochrome c, while downregulating Bcl-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 226.17
Formula C₁₀H₁₁O₄P
SMILES

O=P1(OC)OC2=CC(OC)=CC=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nocentini A, et al. Discovery of a Mixed and Prodrug-Like Inhibition Mechanism for Phosphocoumarins and Phosphoquinolinones against Human Carbonic Anhydrases. J Med Chem. 2026;69(9):11638-11648. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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