CAIX/CAXII-IN-1
Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC50 values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 2439165-37-2
- Formula: C24H21IN4O4S2
- Molecular Weight:620.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
CA XII |
CA Ⅱ |
CA IX |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.019 μM
Compound: 9
|
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability irradiated with 8 Gy gamma radiation and measured after 24 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability irradiated with 8 Gy gamma radiation and measured after 24 hrs by MTT assay
|
[PMID: 32485534] |
| HCT-116 | IC50 |
1.94 μM
Compound: 9
|
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by MTT assay
|
[PMID: 32485534] |
| HepG2 | IC50 |
0.041 μM
Compound: 9
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability irradiated with 8 Gy gamma radiation and measured after 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability irradiated with 8 Gy gamma radiation and measured after 24 hrs by MTT assay
|
[PMID: 32485534] |
| HepG2 | IC50 |
1.775 μM
Compound: 9
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay
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[PMID: 32485534] |
| MCF7 | IC50 |
0.031 μM
Compound: 9
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability irradiated with 8 Gy gamma radiation and measured after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability irradiated with 8 Gy gamma radiation and measured after 24 hrs by MTT assay
|
[PMID: 32485534] |
| MCF7 | IC50 |
3.066 μM
Compound: 9
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by MTT assay
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[PMID: 32485534] |
| WI-38 | IC50 |
3.145 μM
Compound: 9
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Cytotoxicity against human WI-38 cells assessed as reduction in cell viability irradiated with 8 Gy gamma radiation and measured after 24 hrs by MTT assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability irradiated with 8 Gy gamma radiation and measured after 24 hrs by MTT assay
|
[PMID: 32485534] |
| WI-38 | IC50 |
5.714 μM
Compound: 9
|
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by MTT assay
|
[PMID: 32485534] |
Chemical Information
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CAS No. 2439165-37-2
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Molecular Weight 620.48
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Formula C24H21IN4O4S2
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SMILES
IC1=CC=C(N=C2SCC(NC3=CC=CC=C3CC)=O)C(C(N2C4=CC=C(S(N)(=O)=O)C=C4)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAIX/CAXII-IN-1 Related Classifications
HY-146819 Related Classifications
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