2439165-37-2
Chemical Structure
CAIX/CAXII-IN-1
- CAS No.: 2439165-37-2
- Formula:C24H21IN4O4S2
- Molecular Weight:620.48
IUPAC Name: N-(2-ethylphenyl)-2-((6-iodo-4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydroquinazolin-2-yl)thio)acetamide
InChIKey: KBHINLUAWWNHMW-UHFFFAOYSA-N
SMILES: IC1=CC=C(N=C2SCC(NC3=CC=CC=C3CC)=O)C(C(N2C4=CC=C(S(N)(=O)=O)C=C4)=O)=C1
Biological Activity: Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC50 values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity.
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CAIX/CAXII-IN-1 | Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC50 values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity. | |||||||||||||||||||||
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Keywords
