Antitumor agent-163
Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX). Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA). Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC50 is 0.2 and 0.05 μM for A549 and U87MG). Antitumor agent-163 exhibits antitumor efficacy in mouse model.
For research use only. We do not sell to patients.
- Formula: C27H32BF2I2N5O4S
- Molecular Weight:825.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.2 μM
Compound: 3
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Photodynamic antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 60 mins followed by compound washout and light irradiation measured after 72 hrs by MTT assay
Photodynamic antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 60 mins followed by compound washout and light irradiation measured after 72 hrs by MTT assay
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[PMID: 38810709] |
| U-87MG ATCC | IC50 |
0.05 μM
Compound: 3
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Photodynamic antitumor activity against human U87 cells assessed as inhibition of cell growth incubated for 60 mins followed by compound washout and light irradiation measured after 72 hrs by MTT assay
Photodynamic antitumor activity against human U87 cells assessed as inhibition of cell growth incubated for 60 mins followed by compound washout and light irradiation measured after 72 hrs by MTT assay
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[PMID: 38810709] |
Chemical Information
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Molecular Weight 825.26
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Formula C27H32BF2I2N5O4S
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SMILES
O=S(C1=CC=C(C(NCCCCCCNC(CCC2=[N+](C(C=C2I)=C3)[B-](F)(F)N4C3=C(C)C(I)=C4C)=O)=O)C=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-163 Related Classifications
HY-163691 Related Classifications
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