CAIX/XII-IN-17
CAIX/XII-IN-17 is a selective human carbonic anhydrase IX/XII (CA IX/XII) inhibitor with Ki values of 25.1 nM (hCA IX) and 35.2 nM (hCA XII). CAIX/XII-IN-17 induces apoptosis in pancreatic cancer cells. CAIX/XII-IN-17 can be used for the research of breast cancer, pancreatic cancer.
For research use only. We do not sell to patients.
- Formula: C22H17ClN8O2S2
- Molecular Weight:525.01
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hCA IX 25.1 nM (Ki) |
hCA XII 35.2 nM (Ki) |
CAIX/XII-IN-17 (Compound 2g) (15 min) potently inhibits tumor-associated hCA IX (Ki = 25.1 nM) and hCA XII (Ki = 35.2 nM) while showing reduced activity against physiological hCA I and hCA II, resulting in favorable selectivity indices[1].
CAIX/XII-IN-17 (100 μM; 48 h) reduces viability of PANC-1 pancreatic cancer cells under normoxic and hypoxic conditions[1].
CAIX/XII-IN-17 (100 μM; 48 h) induces apoptosis in PANC-1 pancreatic cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PANC-1 pancreatic cancer cells
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Concentration:100 μM
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Incubation Time:48 h
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Result:Significantly reduced cell viability in normoxic PANC-1 cells.
Retained significant antiproliferative activity in hypoxic PANC-1 cells.
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Cell Line:PANC-1 pancreatic cancer cells
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Concentration:100 μM
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Incubation Time:48 h
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Result:Caused a pronounced decrease in the viable cell population relative to untreated control PANC-1 cells.
Induced a concomitant increase in apoptotic cells relative to untreated control PANC-1 cells.
Chemical Information
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Molecular Weight 525.01
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Formula C22H17ClN8O2S2
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SMILES
O=S(C1=CC=CC(N2N=NC(CSC3=NN=C(C4=CC=NC=C4)N3C5=CC=CC=C5Cl)=C2)=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAIX/XII-IN-17 Related Classifications
HY-183590 Related Classifications
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