2. Metabolic Enzyme/Protease Apoptosis
  3. Carbonic Anhydrase Apoptosis
  4. CAIX/XII-IN-17

CAIX/XII-IN-17 is a selective human carbonic anhydrase IX/XII (CA IX/XII) inhibitor with Ki values of 25.1 nM (hCA IX) and 35.2 nM (hCA XII). CAIX/XII-IN-17 induces apoptosis in pancreatic cancer cells. CAIX/XII-IN-17 can be used for the research of breast cancer, pancreatic cancer.

For research use only. We do not sell to patients.

CAIX/XII-IN-17

CAIX/XII-IN-17 Chemical Structure

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CAIX/XII-IN-17 Related Antibodies

Top Publications Citing Use of Products

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CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

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Description

CAIX/XII-IN-17 is a selective human carbonic anhydrase IX/XII (CA IX/XII) inhibitor with Ki values of 25.1 nM (hCA IX) and 35.2 nM (hCA XII). CAIX/XII-IN-17 induces apoptosis in pancreatic cancer cells. CAIX/XII-IN-17 can be used for the research of breast cancer, pancreatic cancer[1].

IC50 & Target[1]

hCA IX

25.1 nM (Ki)

hCA XII

35.2 nM (Ki)

In Vitro

CAIX/XII-IN-17 (Compound 2g) (15 min) potently inhibits tumor-associated hCA IX (Ki = 25.1 nM) and hCA XII (Ki = 35.2 nM) while showing reduced activity against physiological hCA I and hCA II, resulting in favorable selectivity indices[1].
CAIX/XII-IN-17 (100 μM; 48 h) reduces viability of PANC-1 pancreatic cancer cells under normoxic and hypoxic conditions[1].
CAIX/XII-IN-17 (100 μM; 48 h) induces apoptosis in PANC-1 pancreatic cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAIX/XII-IN-17 Related Antibodies

Cell Viability Assay[1]

Cell Line: PANC-1 pancreatic cancer cells
Concentration: 100 μM
Incubation Time: 48 h
Result: Significantly reduced cell viability in normoxic PANC-1 cells.
Retained significant antiproliferative activity in hypoxic PANC-1 cells.

Apoptosis Analysis[1]

Cell Line: PANC-1 pancreatic cancer cells
Concentration: 100 μM
Incubation Time: 48 h
Result: Caused a pronounced decrease in the viable cell population relative to untreated control PANC-1 cells.
Induced a concomitant increase in apoptotic cells relative to untreated control PANC-1 cells.
Molecular Weight

525.01

Formula

C22H17ClN8O2S2
SMILES

O=S(C1=CC=CC(N2N=NC(CSC3=NN=C(C4=CC=NC=C4)N3C5=CC=CC=C5Cl)=C2)=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CAIX/XII-IN-17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAIX/XII-IN-17Carbonic AnhydraseApoptosisCarbonate dehydratasebreast cancercarbonic anhydrase XIIhCA IIcarbonic anhydrase IXPANC-1 pancreatic cancer cellsbreast cancer cellshCA Ipancreatic cancerapoptosispancreatic cancer cellsInhibitorinhibitorinhibit

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