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Cat. No.: HY-183591

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CAIX/XII-IN-18

CAIX/XII-IN-18 is a selective human carbonic anhydrase IX/XII (CA IX/XII) inhibitor with K_i values of 28.1 nM (hCA IX) and 11.6 nM (hCA XII). CAIX/XII-IN-18 induces apoptosis in breast cancer cells. CAIX/XII-IN-18 can be used for the research of breast cancer, pancreatic cancer.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₇ClN₈O₂S₂
Molecular Weight:525.01

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CAIX/XII-IN-18 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

hCA IX

28.1 nM (Ki)

hCA XII

11.6 nM (Ki)

All Carbonic Anhydrase Isoforms :

In Vitro

CAIX/XII-IN-18 (Compound 4g) (15 min) potently inhibits recombinant human hCA IX (K_i = 28.1 nM) and hCA XII (K_i = 11.6 nM) with favorable selectivity over hCA I and hCA II^[1].
CAIX/XII-IN-18 (100 μM; 48 h) reduces MDA-MB-231 breast cancer cell viability under normoxic and hypoxic conditions^[1].
CAIX/XII-IN-18 (100 μM; 48 h) induces apoptosis in MDA-MB-231 breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MDA-MB-231 breast cancer cells
Concentration:

100 μM
Incubation Time:

48 h
Result:

Significantly reduced MDA-MB-231 cell viability under both normoxic and hypoxic conditions when administered alone.

Apoptosis Analysis^[1]

Cell Line:

MDA-MB-231 breast cancer cells
Concentration:

100 μM
Incubation Time:

48 h
Result:

Induced a clear redistribution of the MDA-MB-231 cell population, with a significant reduction in the viable cell fraction and a corresponding increase in apoptotic cells compared to untreated controls.

Chemical Information

Molecular Weight 525.01
Formula C₂₂H₁₇ClN₈O₂S₂
SMILES

O=S(C1=CC=C(N2N=NC(CSC3=NN=C(C4=CC=NC=C4)N3C5=CC=CC=C5Cl)=C2)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Roshdy E, et al. Design and Synthesis of Bis-Triazole-Linked Benzenesulfonamides as Selective Carbonic Anhydrase IX/XII Inhibitors with Chemosensitizing Activity. J Med Chem. 2026;69(9):11365-11381. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CAIX/XII-IN-18

All Carbonic Anhydrase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CAIX/XII-IN-18 Related Classifications

HY-183591 Related Classifications