2. Metabolic Enzyme/Protease Apoptosis
  3. Carbonic Anhydrase Apoptosis
  4. CAIX/XII-IN-18

CAIX/XII-IN-18 is a selective human carbonic anhydrase IX/XII (CA IX/XII) inhibitor with Ki values of 28.1 nM (hCA IX) and 11.6 nM (hCA XII). CAIX/XII-IN-18 induces apoptosis in breast cancer cells. CAIX/XII-IN-18 can be used for the research of breast cancer, pancreatic cancer.

For research use only. We do not sell to patients.

CAIX/XII-IN-18

CAIX/XII-IN-18 Chemical Structure

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CAIX/XII-IN-18 Related Antibodies

Top Publications Citing Use of Products

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Description

CAIX/XII-IN-18 is a selective human carbonic anhydrase IX/XII (CA IX/XII) inhibitor with Ki values of 28.1 nM (hCA IX) and 11.6 nM (hCA XII). CAIX/XII-IN-18 induces apoptosis in breast cancer cells. CAIX/XII-IN-18 can be used for the research of breast cancer, pancreatic cancer[1].

IC50 & Target[1]

hCA IX

28.1 nM (Ki)

hCA XII

11.6 nM (Ki)

In Vitro

CAIX/XII-IN-18 (Compound 4g) (15 min) potently inhibits recombinant human hCA IX (Ki = 28.1 nM) and hCA XII (Ki = 11.6 nM) with favorable selectivity over hCA I and hCA II[1].
CAIX/XII-IN-18 (100 μM; 48 h) reduces MDA-MB-231 breast cancer cell viability under normoxic and hypoxic conditions[1].
CAIX/XII-IN-18 (100 μM; 48 h) induces apoptosis in MDA-MB-231 breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAIX/XII-IN-18 Related Antibodies

Cell Viability Assay[1]

Cell Line: MDA-MB-231 breast cancer cells
Concentration: 100 μM
Incubation Time: 48 h
Result: Significantly reduced MDA-MB-231 cell viability under both normoxic and hypoxic conditions when administered alone.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 breast cancer cells
Concentration: 100 μM
Incubation Time: 48 h
Result: Induced a clear redistribution of the MDA-MB-231 cell population, with a significant reduction in the viable cell fraction and a corresponding increase in apoptotic cells compared to untreated controls.
Molecular Weight

525.01

Formula

C22H17ClN8O2S2
SMILES

O=S(C1=CC=C(N2N=NC(CSC3=NN=C(C4=CC=NC=C4)N3C5=CC=CC=C5Cl)=C2)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CAIX/XII-IN-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAIX/XII-IN-18Carbonic AnhydraseApoptosisCarbonate dehydratasebreast cancer cellspancreatic cancer cellshuman carbonic anhydrase IXazacitidinecatalytic zinchCA IIhuman carbonic anhydrase XIIsorafenibMDA-MB-231 breast cancer cellshCA IInhibitorinhibitorinhibit

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