2. Others Metabolic Enzyme/Protease
  3. Fluorescent Dye Carbonic Anhydrase
  4. GZ22-4

GZ22-4 is a near-infrared (NIR) fluorescent probe. GZ22-4 shows high affinity for carbonic anhydrase IX (CAIX), with a Kd of 0.2 nM. GZ22-4 can be used for the research of visualize CAIX-positive tumors.

For research use only. We do not sell to patients.

GZ22-4

GZ22-4 Chemical Structure

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Based on 1 publication(s) in Google Scholar

GZ22-4 Related Antibodies

Top Publications Citing Use of Products

View All Carbonic Anhydrase Isoform Specific Products:

View All Isoforms
CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GZ22-4 is a near-infrared (NIR) fluorescent probe. GZ22-4 shows high affinity for carbonic anhydrase IX (CAIX), with a Kd of 0.2 nM. GZ22-4 can be used for the research of visualize CAIX-positive tumors[1].

IC50 & Target

CA IX

0.2 nM (Kd)

CA I

 

CA Ⅱ

200 nM (Kd)

CA XII

80 nM (Kd)

Molecular Weight

1860.21

Formula

C88H126F3N6NaO24S4
Appearance

Solid

Color

Light green to green

SMILES

O=S(CCCC[N+]1=C(/C=C/C(CCC/2)=C(OC3=CC=C(CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCS(C4=C(NC5CCCCCCC5)C(F)=C(S(N)(=O)=O)C(F)=C4F)(=O)=O)=O)=O)C=C3)C2=C\C=C6C(C)(C)C(C=CC=C7)=C7N\6CCCCS([O-])(=O)=O)C(C)(C)C8=C1C=CC=C8)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (26.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5376 mL 2.6879 mL 5.3757 mL
5 mM 0.1075 mL 0.5376 mL 1.0751 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5376 mL 2.6879 mL 5.3757 mL 13.4393 mL
5 mM 0.1075 mL 0.5376 mL 1.0751 mL 2.6879 mL
10 mM 0.0538 mL 0.2688 mL 0.5376 mL 1.3439 mL
15 mM 0.0358 mL 0.1792 mL 0.3584 mL 0.8960 mL
20 mM 0.0269 mL 0.1344 mL 0.2688 mL 0.6720 mL
25 mM 0.0215 mL 0.1075 mL 0.2150 mL 0.5376 mL
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GZ22-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GZ22-4Fluorescent DyeCarbonic AnhydraseCarbonate dehydrataseNIRcarbonic anhydrase IXCAIXtumorInhibitorinhibitorinhibit

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