Art. -Nr.: HY-110243

CAIX Inhibitor S4

Name: CAIX Inhibitor S4
Brand: MedChemExpress
SKU: HY-110243
Price: 70.00 USD
Availability: InStock
Rating: 5 (2 reviews)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a K_i of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (K_i=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 98.74%
CAS. Nr.: 1330061-67-0
Formel: C₁₅H₁₇N₃O₄S
Molecular Weight:335.38

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

CAIX Inhibitor S4 Chemical Structure

CAS. Nr.: 1330061-67-0

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

CA IX

Alle Carbonic Anhydrase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	>1000 μM Compound: 9A, S4	Cytotoxicity against human HCT116 cells preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay Cytotoxicity against human HCT116 cells preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay	[PMID: 22621623]
HT-29	IC₅₀	20 μM Compound: 9A, S4	Cytotoxicity against human HT-29 cells preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay Cytotoxicity against human HT-29 cells preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay	[PMID: 22621623]
MDA-MB-231	IC₅₀	481 μM Compound: 9A, S4	Cytotoxicity against EGFP tagged human MDA-MB-231 cells expressing CA9 preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay Cytotoxicity against EGFP tagged human MDA-MB-231 cells expressing CA9 preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay	[PMID: 22621623]

In Vitro

CAIX Inhibitor S4 (1-100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner^[1].
CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration- dependent manner^[1].
CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MDA-MB-231, HCT116 and HT29 cells
Concentration:

1, 10, 100 μM
Incubation Time:

24 hours
Result:

Inhibited the cell proliferation of MDA-MB-231, HCT116 and HT29 cells, with IC₅₀s of 481 μM, >1000 μM, and 20 μM, respectively.

In Vivo

CAIX Inhibitor S4 (10 mg/kg; i.p. for 14 days) inhibits metastatic tumor burden in MDA-MB-231 model while having no effect on primary tumor growth or mouse condition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female nu/nu CBA mice (10-12 weeks) were injected with eGFP-MDA-MB-231 cells^[1]
Dosage:

10 mg/kg
Administration:

I.p. daily on a “5 days on, 2 days off” dosing regimen for 14 days
Result:

Significantly reduced the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors.
The average body weights between vehicle and S4 treated mice were similar throughout the experiments.

Related Protocols :

Chemical Information

CAS. Nr. 1330061-67-0
Appearance Solid
Molecular Weight 335.38
Formel C₁₅H₁₇N₃O₄S
Color White to off-white
SMILES

O=C(NC1=CC(C)=CC(C)=C1)NC2=CC=C(C=C2)OS(=O)(N)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

All

Sort by:

Journal Impact Factor

J Immunother Cancer

Carbonic anhydrase 9 as a circulating biomarker and therapeutic target in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab. [Abstract]

2026 Apr 9;14(4):e013384. PMID: 41956541
bioRxiv

2023 Sep 8.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 250 mg/mL (745.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9817 mL

14.9085 mL

29.8169 mL

5 mM

0.5963 mL

2.9817 mL

5.9634 mL

10 mM

0.2982 mL

1.4908 mL

2.9817 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gieling RG, et, al. Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J Med Chem. 2012 Jun 14;55(11):5591-600. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9817 mL	14.9085 mL	29.8169 mL	74.5423 mL
	5 mM	0.5963 mL	2.9817 mL	5.9634 mL	14.9085 mL
	10 mM	0.2982 mL	1.4908 mL	2.9817 mL	7.4542 mL
	15 mM	0.1988 mL	0.9939 mL	1.9878 mL	4.9695 mL
	20 mM	0.1491 mL	0.7454 mL	1.4908 mL	3.7271 mL
	25 mM	0.1193 mL	0.5963 mL	1.1927 mL	2.9817 mL
	30 mM	0.0994 mL	0.4969 mL	0.9939 mL	2.4847 mL
	40 mM	0.0745 mL	0.3727 mL	0.7454 mL	1.8636 mL
	50 mM	0.0596 mL	0.2982 mL	0.5963 mL	1.4908 mL
	60 mM	0.0497 mL	0.2485 mL	0.4969 mL	1.2424 mL
	80 mM	0.0373 mL	0.1864 mL	0.3727 mL	0.9318 mL
	100 mM	0.0298 mL	0.1491 mL	0.2982 mL	0.7454 mL

Bioz

Keywords

CAIX Inhibitor S4

2 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

CAIX Inhibitor S4

Publications Citing Use of MedChemExpress (MCE) CAIX Inhibitor S4

Alle Carbonic Anhydrase Isoform-spezifische Produkte anzeigen