CAIX Inhibitor S4
Based on 2 publication(s) in Google Scholar
CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth.
For research use only. We do not sell to patients.
- Purity: 99.04%
- CAS No.: 1330061-67-0
- Formula: C15H17N3O4S
- Molecular Weight:335.38
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) CAIX Inhibitor S4
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Biological Activity
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CA IX |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
>1000 μM
Compound: 9A, S4
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Cytotoxicity against human HCT116 cells preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay
Cytotoxicity against human HCT116 cells preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay
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[PMID: 22621623] |
| HT-29 | IC50 |
20 μM
Compound: 9A, S4
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Cytotoxicity against human HT-29 cells preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay
Cytotoxicity against human HT-29 cells preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay
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[PMID: 22621623] |
| MDA-MB-231 | IC50 |
481 μM
Compound: 9A, S4
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Cytotoxicity against EGFP tagged human MDA-MB-231 cells expressing CA9 preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay
Cytotoxicity against EGFP tagged human MDA-MB-231 cells expressing CA9 preincubated for 24 hrs followed by compound washout measured after 96 hrs by MTT assay
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[PMID: 22621623] |
CAIX Inhibitor S4 (1-100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner[1].
CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration- dependent manner[1].
CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231, HCT116 and HT29 cells
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Concentration:1, 10, 100 μM
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Incubation Time:24 hours
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Result:Inhibited the cell proliferation of MDA-MB-231, HCT116 and HT29 cells, with IC50s of 481 μM, >1000 μM, and 20 μM, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female nu/nu CBA mice (10-12 weeks) were injected with eGFP-MDA-MB-231 cells[1]
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Dosage:10 mg/kg
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Administration:I.p. daily on a “5 days on, 2 days off” dosing regimen for 14 days
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Result:Significantly reduced the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors.
The average body weights between vehicle and S4 treated mice were similar throughout the experiments.
Chemical Information
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CAS No. 1330061-67-0
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Appearance Solid
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Molecular Weight 335.38
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Formula C15H17N3O4S
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Color White to off-white
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SMILES
O=C(NC1=CC(C)=CC(C)=C1)NC2=CC=C(C=C2)OS(=O)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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J Immunother Cancer
Carbonic anhydrase 9 as a circulating biomarker and therapeutic target in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab. [Abstract]2026 Apr 9;14(4):e013384. PMID: 41956541 -
Solvent & Solubility
DMSO : 250 mg/mL (745.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9817 mL | 14.9085 mL | 29.8169 mL | 74.5423 mL |
| 5 mM | 0.5963 mL | 2.9817 mL | 5.9634 mL | 14.9085 mL | |
| 10 mM | 0.2982 mL | 1.4908 mL | 2.9817 mL | 7.4542 mL | |
| 15 mM | 0.1988 mL | 0.9939 mL | 1.9878 mL | 4.9695 mL | |
| 20 mM | 0.1491 mL | 0.7454 mL | 1.4908 mL | 3.7271 mL | |
| 25 mM | 0.1193 mL | 0.5963 mL | 1.1927 mL | 2.9817 mL | |
| 30 mM | 0.0994 mL | 0.4969 mL | 0.9939 mL | 2.4847 mL | |
| 40 mM | 0.0745 mL | 0.3727 mL | 0.7454 mL | 1.8636 mL | |
| 50 mM | 0.0596 mL | 0.2982 mL | 0.5963 mL | 1.4908 mL | |
| 60 mM | 0.0497 mL | 0.2485 mL | 0.4969 mL | 1.2424 mL | |
| 80 mM | 0.0373 mL | 0.1864 mL | 0.3727 mL | 0.9318 mL | |
| 100 mM | 0.0298 mL | 0.1491 mL | 0.2982 mL | 0.7454 mL |
CAIX Inhibitor S4 Related Classifications
HY-110243 Related Classifications
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