2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK Apoptosis
  3. Carbonic Anhydrase c-Met/HGFR Apoptosis
  4. CAIX/XII-IN-16

CAIX/XII-IN-16 (Compound 5d) is a selective inhibitor of CA IX/XII and c-Met. CAIX/XII-IN-16‘s Ki values for hCA IX, hCA XII and CA I are 10.6, 31.8 and 2361 nM respectively, and its IC50 value for c-Met is 0.49 μM. CAIX/XII-IN-16 exhibits significantly enhanced cytotoxicity against colon cancer cells under hypoxic conditions. CAIX/XII-IN-16 causes cell cycle arrest and induces apoptosis (apoptosis). CAIX/XII-IN-16 significantly enhances the efficacy of Oxaliplatin (HY-17371) and 5-Fluorouracil (HY-90006). CAIX/XII-IN-16 can be used for studies on chemotherapy resistance related to hypoxia.

For research use only. We do not sell to patients.

CAIX/XII-IN-16

CAIX/XII-IN-16 Chemical Structure

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CAIX/XII-IN-16 Related Antibodies

Top Publications Citing Use of Products

View All Carbonic Anhydrase Isoform Specific Products:

View All Isoforms
CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

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Description

CAIX/XII-IN-16 (Compound 5d) is a selective inhibitor of CA IX/XII and c-Met. CAIX/XII-IN-16‘s Ki values for hCA IX, hCA XII and CA I are 10.6, 31.8 and 2361 nM respectively, and its IC50 value for c-Met is 0.49 μM. CAIX/XII-IN-16 exhibits significantly enhanced cytotoxicity against colon cancer cells under hypoxic conditions. CAIX/XII-IN-16 causes cell cycle arrest and induces apoptosis (apoptosis). CAIX/XII-IN-16 significantly enhances the efficacy of Oxaliplatin (HY-17371) and 5-Fluorouracil (HY-90006). CAIX/XII-IN-16 can be used for studies on chemotherapy resistance related to hypoxia[1].

IC50 & Target[1]

hCA IX

10.6 nM (Ki)

hCA XII

31.8 nM (Ki)

hCA I

2361 nM (Ki)

c-Met

0.49 μM (IC50)

Molecular Weight

439.45

Formula

C19H17N7O4S
SMILES

CC1=CC=CC2=C1NC(/C2=N\NC(C3=C(N(N=N3)C4=CC=C(C=C4)S(N)(=O)=O)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CAIX/XII-IN-16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAIX/XII-IN-16Carbonic Anhydrasec-Met/HGFRApoptosisCarbonate dehydrataseDual CA IX and c-met inhibitorsColon CancerHypoxiaHIF-1αChemosensitizationDockingInhibitorinhibitorinhibit

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