CAIX/XII-IN-16
CAIX/XII-IN-16 (Compound 5d) is a selective inhibitor of CA IX/XII and c-Met. CAIX/XII-IN-16‘s Ki values for hCA IX, hCA XII and CA I are 10.6, 31.8 and 2361 nM respectively, and its IC50 value for c-Met is 0.49 μM. CAIX/XII-IN-16 exhibits significantly enhanced cytotoxicity against colon cancer cells under hypoxic conditions. CAIX/XII-IN-16 causes cell cycle arrest and induces apoptosis (apoptosis). CAIX/XII-IN-16 significantly enhances the efficacy of Oxaliplatin (HY-17371) and 5-Fluorouracil (HY-90006). CAIX/XII-IN-16 can be used for studies on chemotherapy resistance related to hypoxia.
For research use only. We do not sell to patients.
- Formula: C19H17N7O4S
- Molecular Weight:439.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hCA IX 10.6 nM (Ki) |
hCA XII 31.8 nM (Ki) |
hCA I 2361 nM (Ki) |
c-Met 0.49 μM (IC50) |
Chemical Information
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Molecular Weight 439.45
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Formula C19H17N7O4S
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SMILES
CC1=CC=CC2=C1NC(/C2=N\NC(C3=C(N(N=N3)C4=CC=C(C=C4)S(N)(=O)=O)C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAIX/XII-IN-16 Related Classifications
HY-179034 Related Classifications
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