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Results for "

HETE

" in MedChemExpress (MCE) Product Catalog:

84

Inhibitors & Agonists

16

Natural
Products

11

Isotope-Labeled Compounds

2

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0652
    2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside
    3 Publications Verification

    2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside

    		 ERK NF-κB Cardiovascular Disease Neurological Disease
    2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .
    2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside
  • HY-124527
    HET0016
    Maximum Cited Publications
    6 Publications Verification

    		 Cytochrome P450 Cardiovascular Disease Cancer
    HET0016 is a potent and selective 20-hydroxyeicosatetraenoic acid (20-HETE) synthase inhibitor, with IC50 values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis, respectively. HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth .
    HET0016
  • HY-101016
    17-ODYA
    1 Publications Verification

    		 Cytochrome P450 Apoptosis Cardiovascular Disease
    17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC50<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes . 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    17-ODYA
  • HY-160186
    20-SOLA
    1 Publications Verification

    		 Cytochrome P450 Cardiovascular Disease Metabolic Disease Endocrinology
    20-SOLA is an orally active 20-HETE antagonist. 20-SOLA greatly ameliorates changes in blood pressure and renal injury associated with a Streptozotocin (STZ) (HY-13753)-diabetic mouse model. 20-SOLA facilitates the restoration of coronary collateral growth (CCG) after ischemic injury. 20-SOLA can be studied for research in cardiovascular diseases and diabetes .
    20-SOLA
  • HY-160187
    AAA

    		Orphan GPCR Angiotensin Receptor Cardiovascular Disease
    AAA is an orally active 20-HETE receptor antagonist. AAA exerts antihypertensive and organoprotective effects. AAA blocks 20-HETE prohypertensive actions, suppresses intrarenal and circulating angiotensin II levels, and interferes with renin-angiotensin system interactions. AAA attenuates development of, and reverses established, ANG II (HY-13948)-dependent malignant hypertension. AAA reduces albuminuria, glomerulosclerosis, and cardiac hypertrophy linked to malignant hypertension. AAA can be used for the research of malignant hypertension .
    AAA
  • HY-113439
    12-HETE
    2 Publications Verification

    		 Apoptosis Cardiovascular Disease Inflammation/Immunology
    12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway [1].12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .
    12-HETE
  • HY-101527
    20-HEDE
    2 Publications Verification

    WIT 002

    		 Cytochrome P450 Cancer
    20-HEDE (WIT 002) is an antagonist of 20-hydroxyeicosatetraenoic acid (20-HETE).
    20-HEDE
  • HY-148226
    20-5,14-HEDGE

    		Apoptosis Reactive Oxygen Species (ROS) Cardiovascular Disease
    20-5,14-HEDGE is a 20-HETE analog. 20-5,14-HEDGE induces cell death in organotypic hippocampal slice cultures (OHSCs). 20-5,14-HEDGE enhances ROS production and reduces hypoxia-reoxygenation (HR)-induced apoptosis in ex vivo rat lung slices. 20-5,14-HEDGE protects against lung ischemic reperfusion injury in rats. 20-5,14-HEDGE can be used for the study of pulmonary vascular signaling and lung injury-related research .
    20-5,14-HEDGE
  • HY-156876
    20-HETE inhibitor-2

    		Cytochrome P450 Metabolic Disease
    20-HETE inhibitor-2 is an orally active 20-HETE inhibitor. 20-HETE inhibitor-2 can inhibit the activities of CYP4F2 and CYP4A11, thereby suppressing the production of 20-HETE. 20-HETE inhibitor-2 has the effect of improving blood glucose and can be used for the research of various diseases related to 20-HETE such as obesity .
    20-HETE inhibitor-2
  • HY-113439S
    12-HETE-d8
    2 Publications Verification

    		 Apoptosis Cardiovascular Disease Inflammation/Immunology
    12-HETE-d8 is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway [1].12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .
    12-HETE-d8
  • HY-124404A
    12(S)-HETE

    		ERK DNA/RNA Synthesis p38 MAPK Cancer
    12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells .
    12(S)-HETE
  • HY-B0881
    Acetohexamide
    2 Publications Verification

    		 Potassium Channel Metabolic Disease Cancer
    Acetohexamide is an orally active first-generation sulfonylurea agent used in research related to type 2 diabetes and cancer. Acetohexamide exerts reductase activity in human erythrocytes. Acetohexamide stimulates the pancreas to secrete insulin. Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. Acetohexamide can inhibit the formation of circular chemorepellent induced defects (CCIDs) in lymphendothelial cell (LEC) monolayers. Acetohexamide inhibits markers of epithelial-to-mesenchymal-transition and migration. Acetohexamide suppresses the synthesis of 12(S)-HETE. Acetohexamide can potentiate hypoglycaemic action .
    Acetohexamide
  • HY-15598S
    20-HETE-d6

    20-Hydroxyarachidonic acid-d6; 20-Hydroxyeicosatetraenoic acid-d6

    		 Isotope-Labeled Compounds Others
    20-HETE-d6 is the deuterium labeled 20-HETE.
    20-HETE-d6
  • HY-113120
    Stearidonic acid

    6Z,9Z,12Z,15Z-Octadecatetraenoic acid

    		 Lipoxygenase Metabolic Disease
    Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit 5-lipoxygenase and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease .
    Stearidonic acid
  • HY-113438
    15(S)-HPETE

    		Drug Metabolite Bcl-2 Family Akt Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies .
    15(S)-HPETE
  • HY-113336B
    (±)15-HETE

    		PROTAC Linkers Cancer
    (±)15-HETE is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
    (±)15-HETE
  • HY-113434S
    5(S)-HETE-d8

    		Endogenous Metabolite Others
    5(S)-HETE-d8 is the deuterium labeled 5(S)-HETE .
    5(S)-HETE-d8
  • HY-113336
    15(S)-HETE

    		Endogenous Metabolite Inflammation/Immunology
    15(S)-HETE is an endogenous metabolite present in Urine that can be used for the research of Zellweger Syndrome .
    15(S)-HETE
  • HY-160099
    20-5,14-HEDE

    WIT003

    		 Apoptosis Caspase DNA/RNA Synthesis PI3K Akt Reactive Oxygen Species (ROS) Cardiovascular Disease
    20-5,14-HEDE (WIT003) is an analog of 20-HETE. 20-5,14-HEDE activates PI3K/Akt signaling pathway, thereby exhibiting anti-apoptotic and cell survival promoting effects. 20-5,14-HEDE is the agonist for 20-HETE that increases intracellular Ca 2+ concentrations, thereby enhancing vasoconstriction .
    20-5,14-HEDE
  • HY-113434B
    5-HETE

    (±)-5-HETE

    		 Endogenous Metabolite Inflammation/Immunology
    5-HETE ((±)-5-HETE), a fatty acid, is a oxidative derivative of Arachidonic acid. 5-HETE is a mixture of 5(S)-HETE and 5(R)-HETE. 5-HETE is a potent aggregating agent that induces the aggregation of neutrophils with an IC50 value of 200 nM .
    5-HETE
  • HY-113336S
    15(S)-HETE-d8

    		Endogenous Metabolite Isotope-Labeled Compounds Others
    15(S)-HETE-d8 is the deuterium labeled 15(S)-HETE .
    15(S)-HETE-d8
  • HY-113434
    5(S)-HETE
    1 Publications Verification

    		 Endogenous Metabolite Inflammation/Immunology
    5(S)-HETE is an endogenous metabolite present in Blood that can be used for the research of Rheumatoid Arthritis, Rhinitis and Asthma .
    5(S)-HETE
  • HY-160187A
    (Rac)-AAA

    		Cadherin MMP Akt FAK ERK NF-κB Cancer
    (Rac)-AAA is a regulator and inhibitor targeting GPR75. By blocking the 20-HETE-induced downregulation of GPR75 expression, (Rac)-AAA effectively inhibits the activation of key downstream signaling pathways including EGFR, AKT, NF-κB and FAK. (Rac)-AAA reverses 20-HETE-mediated epithelial-mesenchymal transition, which is specifically characterized by downregulating vimentin (vimentin), upregulating E-Cadherin, as well as reducing MMP-2 activity and cancer cell migration ability. (Rac)-AAA also abolishes the 20-HETE-induced upregulation of HIC-5 expression and anchorage-independent growth, and modulates the subcellular localization of PKC-α and phosphorylated AKT. (Rac)-AAA is investigated in androgen-independent prostate cancer (castration-resistant prostate cancer) .
    (Rac)-AAA
  • HY-113943A
    9-HETE

    (±)9-HETE

    		 Endogenous Metabolite Others
    9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .
    9-HETE
  • HY-116196
    17-HETE

    		Na+/K+ ATPase Cytochrome P450 Cardiovascular Disease Inflammation/Immunology
    17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy .
    17-HETE
  • HY-113336A
    15(R)-HETE

    		Drug Isomer Others
    15(R)-HETE is an isomer of 15-HETE. 15-HETE is a lipid mediator derived from arachidonic acid and can be used for the study of asthma .
    15(R)-HETE
  • HY-124404
    12(R)-HETE

    		Aryl Hydrocarbon Receptor Na+/K+ ATPase Prostaglandin Receptor Inflammation/Immunology
    12(R)-HETE is a CYP-dependent arachidonic acid metabolite that acts as a proinflammatory lipid mediator. 12 (R)-HETE widely exists in various tissues including the eye, skin and liver. In the cornea, 12(R)-HETE is metabolized via pathways such as β-oxidation into the precursor of 12(R)-HETrE. Without direct receptor binding, 12(R)-HETE indirectly activates AHR-mediated target gene transcription, while inhibiting the enzymatic activity of Na+,K+-ATPase and the intracellular calcium elevation induced by TP agonists. 12(R)-HETE also possesses multiple physiological effects such as chemotaxis, proangiogenesis, vasodilation, natriuresis, diuresis and intraocular pressure reduction, and can be widely used in studies related to psoriasis, inflammatory skin diseases and ocular inflammation .
    12(R)-HETE
  • HY-112653
    8(S)-HETE

    8(S)-Hydroxyeicosatetraenoic acid

    		 PPAR Inflammation/Immunology
    8(S)-HETE (8(S)-Hydroxyeicosatetraenoic acid) is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
    8(S)-HETE
  • HY-113490
    15-KETE

    		Drug Derivative Metabolic Disease
    15-KETE (15-KETE) is produced by oxidation of the 15-hydroxyl of 15-HETE.
    15-KETE
  • HY-N0652R
    2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard)

    2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside (Standard)

    		 Reference Standards ERK NF-κB Cardiovascular Disease Neurological Disease
    2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard) is the analytical standard of 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside. This product is intended for research and analytical applications. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .
    2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard)
  • HY-117085
    Lobaric acid

    		Phosphatase TMV Lipoxygenase Cancer
    Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC50=97.9 μM) and inhibits cancer cell proliferation (EC50 of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC50=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).
    Lobaric acid
  • HY-143677S
    (±)11-HETE-d8

    		Isotope-Labeled Compounds Others
    (±)11-HETE-d8 is the deuterium labeled (±)11-HETE .
    (±)11-HETE-d8
  • HY-118332
    19(R)-HETE

    		Prostaglandin Receptor Cardiovascular Disease
    19(R)-HETE is a vasodilator in renal arteries, whereas 19(S)-HETE was relatively inactive .
    19(R)-HETE
  • HY-116246
    5(S)-HETE lactone

    		Drug Metabolite Inflammation/Immunology
    5(S)-HETE lactone is an arachidonic acid (AA) metabolite .
    5(S)-HETE lactone
  • HY-158843
    15(S)-Hete-biotin

    15(S)-Hydroxyeicosatetraenoic acid-biotin

    		 Endogenous Metabolite Others
    15(S)-Hete-biotin (15(S)-Hydroxyeicosatetraenoic acid-biotin) can be used to detect 15(S)-HETE binding proteins and/or receptors. 15(S)-HETE is an arachidonic acid metabolite produced by the 15-lipoxygenase pathway .
    15(S)-Hete-biotin
  • HY-W472509
    11-HETE

    11-Hydroxy-5,8,12,14-eicosatetraenoic acid

    		 Cytochrome P450 Cardiovascular Disease
    11-HETE (11-Hydroxy-5,8,12,14-eicosatetraenoic acid) is the activator for cytochrome P450. 11-HETE upregulates the mRNA expressions of CYP1B1, CYP1A1, CYP4A11, CYP4F11, and CYP4F2, induces cell hypertrophy in RL-14 cell, and exhibits potential to be used in cardiovascular diseases .
    11-HETE
  • HY-139114
    20-Carboxyarachidonic acid

    		PPAR Metabolic Disease
    20-Carboxyarachidonic acid, a relatively stable metabolite of 20-HETE, is an endogenous dual activator of PPARalpha and PPARgamma .
    20-Carboxyarachidonic acid
  • HY-121188
    DDMS

    Dibromo-dodecenyl-methylsulfimide

    		 Cytochrome P450 Cardiovascular Disease
    DDMS (Dibromo-dodecenyl-methylsulfimide) is a selective 20-HETE production inhibitor. DDMS attenuates the vasodilatory response to sodium nitroprusside (SNP) .
    DDMS
  • HY-117317
    BLX-2477

    		Lipoxygenase Inflammation/Immunology
    BLX-2477 is a potent and selective 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 99 nM. BLX-2477 can inhibit the generation of inflammatory lipid mediators such as 15-hydroxy-eicosatetraenoic acid (15-HETE). BLX-2477 can be used for the research of inflammation and immunology .
    BLX-2477
  • HY-139945S
    (±)15-HETE-d8

    		Isotope-Labeled Compounds Others
    (±)15-HETE-d8 is the deuterium labeled (±)15-HETE .
    (±)15-HETE-d8
  • HY-112653A
    (±)8-HETE

    8-Hydroxy-5(Z),9(E),11(Z),14(Z)-eicosatetraenoic acid

    		 Endogenous Metabolite Metabolic Disease
    (±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of Arachidonic acid (HY-109590). The biological activity of (±)8-HETE is likely to resemble that of its constituent enantiomers (8(R)-HETE and 8(S)-HETE).
    (±)8-HETE
  • HY-113943AS
    9-HETE-d8

    (±)9-HETE-d8

    		 Isotope-Labeled Compounds Others
    9-HETE-d8 ((±)9-HETE-d8) is the deuterium labeled 9-HETE (HY-113943A) .
    9-HETE-d8
  • HY-130220
    (±)5-HETE lactone

    		Drug Isomer Inflammation/Immunology
    (±)5-HETE lactone is the racemate of 5-HETE lactone. 5-HETE lactone is a metabolite generated by a series of enzymatic reactions of arachidonic acid, and is also a substrate of paraoxonase-1 (PON1). 5-HETE lactone can be used in the study of B cell activation .
    (±)5-HETE lactone
  • HY-113943
    9(S)-HETE

    		Endogenous Metabolite Others
    9(S)-HETE is the S isomer of 9-HETE (HY-113943A). 9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .
    9(S)-HETE
  • HY-113516
    20-HETE Ethanolamide

    		Endogenous Metabolite Neurological Disease
    20-HETE Ethanolamide is a metabolite of endocannabinoid Anandamide. 20-HETE Ethanolamide binds to the rat brain cannabinoid CB1 receptor with a Ki of 985 nM .
    20-HETE Ethanolamide
  • HY-116444A
    16-HETE

    		Na+/K+ ATPase Cardiovascular Disease Inflammation/Immunology
    16-HETE is arachidonic acid metabolite through subterminal hydroxylation by cytochrome P-450. 16-HETE exhibits vasodilatory and PMN inhibitory effects and serves as biomarker for early stages of non-alcoholic fatty liver disease .
    16-HETE
  • HY-156875
    20-HETE inhibitor-1

    		Cytochrome P450 Others
    20-HETE inhibitor-1 (comp 83) is a 20-HETE formation inhibitor
    20-HETE inhibitor-1
  • HY-130219
    18-HETE

    		Endogenous Metabolite Others
    18-HETE (compound 3) is a monooxygenase metabolite of cytochrome P450 (CYP450).18- HETE consists of arachidonic acid bearing a hydroxy substituent at position 18 .
    18-HETE
  • HY-134132
    15(S)-HETE methyl ester

    Methyl 15(S)-HETE

    		 Drug Intermediate Others
    15(S)-HETE methyl ester (Methyl 15(S)-HETE) (compound 1) is a derivative of 15(S)-HETE (HY-113336), a endogenous metabolite presenting in Urine that can be used for the research of Zellweger Syndrome. 15(S)-HETE methyl ester is commonly used in formations of nutritional supplements .
    15(S)-HETE methyl ester
  • HY-113434A
    5(R)-HETE

    		Endogenous Metabolite Inflammation/Immunology
    5(R)-HETE is a lipoxygenase product of arachidonic acid. 5(R)-HETE is an inducer of neutrophil migration through endothelial and epithelial barriers. 5(R)-HETE is important in mediating lung inflammatory processes .
    5(R)-HETE

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