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Cat. No.: HY-182771

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20-HETE IN-3

20-HETE IN-3 is an orally bioavailable 20-HETE synthesis inhibitor. 20-HETE IN-3 can be used in the research of obesity.

For research use only. We do not sell to patients.

CAS No.: 3119850-82-4
Formula: C₂₃H₂₆N₄O
Molecular Weight:374.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

20-HETE IN-3 Chemical Structure

CAS No.: 3119850-82-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

20-HETE IN-3 is an orally bioavailable 20-HETE synthesis inhibitor. 20-HETE IN-3 can be used in the research of obesity^[1].

All Cytochrome P450 Isoforms :

In Vitro

20-HETE IN-3 (example 1) (0-2 μM, HLM; 0-10 μM, RLM; 20 min) potently inhibits the production of 20-HETE in human liver microsomes and rat liver microsomes, with an IC₅₀ of 32.24 nM in human liver microsomes and an IC₅₀ of 20.12 nM in rat liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	AUC_0-24	T_1/2
Mice^[1]	10 mg/kg	p.o.	3224 ng/mL	40316 ng·h/mL	4.94 h

In Vivo

20-HETE IN-3 (Example 1) (10 mg/kg, 10 mL/kg; p.o.; single dose) exhibits a high peak plasma concentration (C_max of 3224 ng/mL) and in vivo exposure level (AUC_{0-24 h} of 40316 ng·h/mL) with an elimination half-life of 4.94 h after oral administration to mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3119850-82-4
Molecular Weight 374.48
Formula C₂₃H₂₆N₄O
SMILES

O=C1N(CC2CCN(CC2)C3=CC4=CC=C(C5=CNN=C5)C=C4C=C3)CCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Marie BERUBE, et al. Caspase-4 inhibitors and uses thereof. WO2026055444A1. 2025-09-05.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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20-HETE IN-3

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

20-HETE IN-3 Related Classifications

HY-182771 Related Classifications