8(S)-HETE
Based on 1 Customer Validation
8(S)-HETE (8(S)-Hydroxyeicosatetraenoic acid) is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 98462-03-4
- Formula: C20H32O3
- Molecular Weight:320.47
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Storage:
Solution, -20°C, 2 years
Biological Activity
Description
Chemical Information
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CAS No. 98462-03-4
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Appearance Liquid
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Molecular Weight 320.47
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Formula C20H32O3
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C/C=C/C=C\[C@H](C/C=C\CCCC(O)=O)O
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Synonyms
8(S)-Hydroxyeicosatetraenoic acid
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (264 KB)
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SDS (604 KB)
- English - EN (604 KB)
- Français - FR (604 KB)
- Deutsch - DE (604 KB)
- Norwegian - NO (604 KB)
- Español - ES (604 KB)
- Swedish - SV (604 KB)
- Italian - IT (604 KB)
- Korean - KR (604 KB)
- Portuguese - PT (604 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)