98462-03-4
Chemical Structure
8(S)-HETE
Synonym(s): 8(S)-Hydroxyeicosatetraenoic acid
- CAS No.: 98462-03-4
- Formula:C20H32O3
- Molecular Weight:320.47
IUPAC Name: (S,5Z,9Z,11E,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid
InChIKey: NLUNAYAEIJYXRB-FHBXLWLHSA-N
SMILES: CCCCC/C=C\C/C=C/C=C\[C@H](C/C=C\CCCC(O)=O)O
Biological Activity: 8(S)-HETE (8(S)-Hydroxyeicosatetraenoic acid) is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
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8(S)-HETE | 99.9% | 8(S)-HETE (8(S)-Hydroxyeicosatetraenoic acid) is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results. | ||||||||||||||||||||
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Keywords
