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Lox+Inhibitors

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42

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y1750
    β-Aminopropionitrile
    10+ Cited Publications

    BAPN

    		 Monoamine Oxidase Endogenous Metabolite Metabolic Disease Cancer
    β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes .
    β-Aminopropionitrile
  • HY-138625A
    PXS-5505 anhydrous
    2 Publications Verification

    LOX-IN-3 dihydrochloride

    		 Monoamine Oxidase Cancer
    PXS-5505 anhydrous (LOX-IN-3 dihydrochloride) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 anhydrous can be used for fibrosis, cancer and angiogenesis research .
    PXS-5505 anhydrous
  • HY-138625
    PXS-5505 free base
    2 Publications Verification

    LOX-IN-3

    		 Monoamine Oxidase Cancer
    PXS-5505 free base (LOX-IN-3) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 free base can be used for fibrosis, cancer and angiogenesis research .
    PXS-5505 free base
  • HY-B1452
    Licofelone
    1 Publications Verification

    ML-3000

    		 COX Lipoxygenase Apoptosis Inflammation/Immunology Cancer
    Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins .
    Licofelone
  • HY-108448
    N-Oleoyldopamine

    OLDA

    		 TRP Channel Lipoxygenase Cardiovascular Disease Neurological Disease Metabolic Disease
    N-Oleoyldopamine (OLDA) is an orally active TRPV1 activator and 5-LOX inhibitor with blood-brain barrier permeability. N-Oleoyldopamine excites histaminergic neurons in the tuberomammillary nucleus via a dopamine receptor mechanism, a process independent of TRPV1 and cannabinoid receptors. On one hand, N-Oleoyldopamine promotes the release of insulin and glucose-dependent insulinotropic polypeptide through a GPR119-dependent pathway to improve glucose tolerance; on the other hand, N-Oleoyldopamine improves left ventricular function and reduces myocardial infarction size by triggering the release of substance P and calcitonin gene-related peptide. N-Oleoyldopamine is used in studies related to glycemic abnormalities and myocardial ischemia-reperfusion injury .
    N-Oleoyldopamine
  • HY-171955
    LXG6403

    		Lipoxygenase Apoptosis Reactive Oxygen Species (ROS) FAK Cancer
    LXG6403 is an orally active and irreversible LOX inhibitor (IC50 = 1.3 μM). LXG6403 is ~3.5-fold more specific for LOX than LOXL2 and does not inhibit LOXL1. LXG6403 inhibits FAK signaling and induces ROS generation and DNA damage, leading to G1 arrest and apoptosis in chemoresistant triple-negative breast cancer (TNBC) cell lines. LXG6403 alters the extracellular matrix (ECM) and collagen structure, reducing collagen cross-linking and deposition, thereby increasing drug penetration and reducing tumor stiffness. LXG6403 overcomes Doxorubicin (HY-15142) resistance in chemoresistant TNBC PDX in vivo and can be used to study high-stiffness resistant tumors .
    LXG6403
  • HY-170538
    SNT-5382

    		Lysyl Oxidase Cytochrome P450 Cardiovascular Disease Metabolic Disease
    SNT-5382 is a lysyl oxidase family (LOX) inhibitor and anti-fibrotic agent. SNT-5382 binds to the LTQ cofactor of LOXL2 and inhibits the enzymatic activities of LOXL3, LOXL4, LOXL1, CYP2C9, and CYP2C19. SNT-5382 reduces cardiac and liver fibrosis as well as collagen crosslinks, and improves cardiac function. SNT-5382 can be used for the research of heart failure, myocardial infarction, and nonalcoholic steatohepatitis-related liver fibrosis .
    SNT-5382
  • HY-Y1750A
    β-Aminopropionitrile hydrochloride
    10+ Cited Publications

    BAPN hydrochloride

    		 Monoamine Oxidase Endogenous Metabolite Metabolic Disease Cancer
    β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes .
    β-Aminopropionitrile hydrochloride
  • HY-124674A
    CCT365623 hydrochloride
    1 Publications Verification

    		 Monoamine Oxidase EGFR Akt TGF-beta/Smad Cancer
    CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor, with an IC50 of 0.89 μM. CCT365623 hydrochloride suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF. CCT365623 hydrochloride is extremely well tolerated, and has good pharmacokinetic properties .
    CCT365623 hydrochloride
  • HY-N11072
    Tremulacin

    		Lipoxygenase Leukotriene Receptor Reactive Oxygen Species (ROS) MMP Inflammation/Immunology
    Tremulacin is a 5-LOX inhibitor. Tremulacin reduces the biosynthesis of LTB4 and slow-reacting substances of anaphylaxis. Tremulacin alleviates carrageenan-induced paw edema in rats, croton oil-induced ear edema in mice, and acetic acid-induced writhing response in mice. Tremulacin inhibits TNF-α-stimulated ROS production and MMP-1 expression, and promotes collagen secretion in human dermal fibroblasts. Tremulacin is investigated for studies on inflammation-related diseases .
    Tremulacin
  • HY-138625B
    PXS-5505

    LOX-IN-3 dihydrochloride monohydrate

    		 Monoamine Oxidase Cardiovascular Disease Cancer
    PXS-5505 (LOX-IN-3 dihydrochloride monohydrate) (Compound 33) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 can be used for fibrosis, cancer and angiogenesis research .
    PXS-5505
  • HY-151173
    XO/COX/LOX-IN-1

    		Xanthine Oxidase Lipoxygenase COX Metabolic Disease Inflammation/Immunology
    XO/COX/LOX-IN-1 is a XO/COX/LOX inhibitor with an IC50 of 3.2 μM against rat XO, 10.83 μM against 5-LOX, 12.67 μM against COX-1, and 8.31 μM against COX-2. XO/COX/LOX-IN-1 binds to the active sites of XO, 5-LOX, COX-1 and COX-2, thereby blocking enzyme activities associated with uric acid, leukotriene, prostaglandin synthesis and inflammatory pathways. XO/COX/LOX-IN-1 can be used in the research of hyperuricemia and inflammation .
    XO/COX/LOX-IN-1
  • HY-Y1750R
    β-Aminopropionitrile (Standard)

    		Reference Standards Monoamine Oxidase Endogenous Metabolite Metabolic Disease Cancer
    β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes .
    β-Aminopropionitrile (Standard)
  • HY-106835
    Flobufen

    VUFB 16066

    		 COX Lipoxygenase Inflammation/Immunology
    Flobufen (VUFB 16066) is a non-steroidal anti-inflammatory agent and cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor agent. Flobufen inhibits alloantigen-driven cellular immune responses and stimulates phagocytosis of peritoneal cells. Flobufen can improve immunopathological disorders and has an inhibitory effect on rheumatoid arthritis .
    Flobufen
  • HY-175970
    MLS000099089

    		Lipoxygenase Neurological Disease
    MLS000099089 is a 12/15-lipoxygenase (12/15-LOX) inhibitor with IC50 values of 3.4 μM and 10 μM for human and mice 12/15-LOX, respectively. MLS000099089 displays higher selectivity for 12/15-LOX over 5-LOX and COX-2. MLS000099089 can be used for the study of stroke .
    MLS000099089
  • HY-B1452R
    Licofelone (Standard)

    ML-3000 (Standard)

    		 COX Lipoxygenase Apoptosis Reference Standards Inflammation/Immunology Cancer
    Licofelone (Standard) is the analytical standard of Licofelone. This product is intended for research and analytical applications. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins .
    Licofelone (Standard)
  • HY-158204
    CNB-001

    		Lipoxygenase Amyloid-β Reactive Oxygen Species (ROS) Apoptosis Neurological Disease Metabolic Disease Inflammation/Immunology
    CNB-001 is a potent and orally active 5-lipoxygenase (5-LOX) inhibitor. CNB-001 can decreases 5-LOX expression and increase proteasome activity. CNB-001 can inhibit accumulation of soluble Amyloid-β and ubiquitinated aggregated proteins. CNB-001 can inhibit apoptosis, ROS production and stabilize mitochondrial membrane potential. CNB-001 can reduce insulin resistance and increase glucose uptake. CNB-001 also exhibits anti-ischemic, anti-inflammatory effects. CNB-001 can be used for the researches of inflammation, neurological and metabolic disease, such as Alzheimer's disease, stroke and diabetes .
    CNB-001
  • HY-119462
    Tagorizine

    		Lipoxygenase Cardiovascular Disease Inflammation/Immunology
    Tagorizine is a 5-LOX inhibitor. Tagorizine can be used to study cerebral (or peripheral) blood vessel dilation .
    Tagorizine
  • HY-124674
    CCT365623

    		Lipoxygenase Cancer
    CCT365623 is a potent and orally active LOX inhibitor with an IC50 of 0.9 μM. CCT365623 has potent anti-metastatic efficacy in vivo .
    CCT365623
  • HY-117514
    5-LOX-IN-7

    		Monoamine Oxidase Inflammation/Immunology Cancer
    5-LOX-IN-7 (compound 18) is a potent LOX inhibitor. 5-LOX-IN-7 has the potential for the research of inflammatory and allergic diseases and certain cancer .
    5-LOX-IN-7
  • HY-149476
    5-LOX-IN-5

    		Lipoxygenase Neurological Disease
    5-LOX-IN-5 (Compound 29) is a 5-LOX inhibitor (IC50: 56 nM). 5-LOX-IN-5 can be used for research of neurodegenerative diseases .
    5-LOX-IN-5
  • HY-173056
    Ruthenoleuton

    		Lipoxygenase Inflammation/Immunology
    Ruthenoleuton is a 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 3.49 μM and a Ki of 0.80 μM. Ruthenoleuton has antioxidant activity and can be used in the research of inflammatory diseases .
    Ruthenoleuton
  • HY-155409
    ALR-38

    		Lipoxygenase Inflammation/Immunology
    ALR-38 is a 5-lipoxygenase (5-LOX) inhibitor (IC50: 1.1 μM) with anti-inflammatory activity. ALR-38 effectively reduces ROS levels in neutrophils .
    ALR-38
  • HY-161315
    15-LOX-IN-1

    		Lipoxygenase Inflammation/Immunology
    15-LOX-IN-1 (Compound 7c) is a 15-LOX inhibitor with a IC50 value of 1.92 μM. 15-LOX-IN-1 has anti-inflammatory activity .
    15-LOX-IN-1
  • HY-163187
    COX-2/LOX-IN-1

    		COX Lipoxygenase Inflammation/Immunology
    COX-2/LOX-IN-1 (compound 5) is a dual cyclooxygenase-2/lipoxygenase (COX-2/LOX) inhibitor with IC50s of 30 μM and 0.55 μM, for LOX and COX-2, respectively. .
    COX-2/LOX-IN-1
  • HY-118268
    RG 6866

    		Lipoxygenase Cardiovascular Disease
    RG 6866 is a 5-lipoxygenase (5-LOX) inhibitor with the potential to inhibit coronary artery constriction and negative cardiac inotropic effects in cardiac inflammatory states. When the heart is stimulated by antigens, RG 6866 can block the antigen-induced reduction in coronary flow in the heart.
    RG 6866
  • HY-155159
    COX-2/15-LOX-IN-2

    		COX Lipoxygenase Inflammation/Immunology
    COX-2/15-LOX-IN-2 is a potent dual COX-2 and 15-LOX inhibitor with IC50 values of 0.065 μM and 1.86 μM, respectively. COX-2/15-LOX-IN-2 has potent antioxidant activity .
    COX-2/15-LOX-IN-2
  • HY-162523
    hMAO-B-IN-8

    		Monoamine Oxidase Cholinesterase (ChE) COX Lipoxygenase Neurological Disease
    hMAO-B-IN-8 (Compound 23) is a hMAO-B, eeAChE, COX-2 and 5-LOX inhibitor, with IC50 values of 0.037 μM, 0.071 μM, 14.3 μM and 0.59 μM, respectively. hMAO-B-IN-8 can be used for the research of Alzheimer's disease .
    hMAO-B-IN-8
  • HY-113807
    ZLJ-6

    		COX Lipoxygenase Inflammation/Immunology
    ZLJ-6 is a dual COX and 5-LOX inhibitor with oral activity. The IC50 values for COX-1, COX-2 and 5-LOX were 0.73, 0.31 and 0.99 μM, respectively. ZLJ-6 has anti-inflammatory and analgesic activity .
    ZLJ-6
  • HY-118848
    A63162

    		Lipoxygenase Leukotriene Receptor Inflammation/Immunology
    A63162 is a specific 5-lipoxygenase (5-LOX) inhibitor. A63162 inhibits mitogen (PHA)-induced horse mononuclear cell (BMC) proliferation and inhibits Calcimycin (HY-N6687)-induced leukotriene LTB4 synthesis at the same concentration. A63162 can be used in the study of chronic obstructive pulmonary disease, arthritis and inflammatory bowel disease .
    A63162
  • HY-B1452S1
    Licofelone-d6

    ML-3000-d6

    		 Apoptosis Lipoxygenase COX Cancer
    Licofelone-d6 is the deuterium labeled Licofelone . Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins .
    Licofelone-d6
  • HY-147951
    COX-2/5-LOX-IN-3

    		COX Lipoxygenase Inflammation/Immunology
    COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual COX-2/5-LOX inhibitor with IC50 values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases .
    COX-2/5-LOX-IN-3
  • HY-150548
    COX-2/15-LOX-IN-1

    		COX Lipoxygenase Inflammation/Immunology
    COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity .
    COX-2/15-LOX-IN-1
  • HY-173180
    5-LOX-IN-8

    		Lipoxygenase Interleukin Related TNF Receptor IFNAR Inflammation/Immunology
    5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory activity. 5-LOX-IN-8 suppresses IL-6, IL-1β, TNF-α and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. 5-LOX-IN-8 reduces disease activity in a DSS colitis model. 5-LOX-IN-8 can be used for research of inflammatory bowel disease (IBD) .
    5-LOX-IN-8
  • HY-155243
    12R-LOX-IN-1

    		DNA/RNA Synthesis Inflammation/Immunology
    12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research .
    12R-LOX-IN-1
  • HY-173115
    15-LOX-IN-2

    		COX Lipoxygenase Interleukin Related PPAR Metabolic Disease Inflammation/Immunology
    15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases .
    15-LOX-IN-2
  • HY-N18235
    (1Z)-Atractylodinol

    		Lipoxygenase Inflammation/Immunology
    (1Z)-Atractylodinol, an acetylenes compound, is a weak 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 17.8 μM. (1Z)-Atractylodinol can be used for the study of inflammatory diseases .
    (1Z)-Atractylodinol
  • HY-N18218
    Speranskoside

    		COX Lipoxygenase Inflammation/Immunology
    Speranskoside is a dual COX-2/15-LOX inhibitor with a COX-2 IC50 of 2.62 μg/mL and a 15-LOX IC50 of 5.51 μg/mL. Speranskoside can be used for the research of gastric ulcers .
    Speranskoside
  • HY-180363
    E 6080

    		Lipoxygenase Leukotriene Receptor Inflammation/Immunology
    E 6080 is an orally active and selective 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 0.2 μM in rat basophilic leukemia cell. E 6080 shows potent inhibitory effects on the release of leukotrienes. E 6080 inhibits the bronchospasm induced by antigen (ovalbumin) inhalation in sensitized conscious guinea pigs. E 6080 can be used for the study of asthma .
    E 6080
  • HY-N17462
    Methyl 9-hydroxyoctadeca-10,12,15-trienoate

    		Monoamine Oxidase Inflammation/Immunology
    Methyl 9-hydroxyoctadeca-10,12,15-trienoate is a soybean lipoxygenase (LOX) inhibitor. Methyl 9-hydroxyoctadeca-10,12,15-trienoate inhibits TPA (HY-18739)-induced ear edema/inflammation in mice. Methyl 9-hydroxyoctadeca-10,12,15-trienoate can be used for the research of inflammation .
    Methyl 9-hydroxyoctadeca-10,12,15-trienoate
  • HY-N19724
    Buddledin A

    		Fungal Lipoxygenase COX Infection
    Buddledin A is a 5-LOX inhibitor (IC50 = 50.4 μM) and a COX inhibitor (IC50 = 13.7 μM). Buddedin A inhibits arachidonic acid metabolism via the 5-LOX and COX pathways, suppresses fungal growth, and exerts toxic effects on fish. Buddedin A may play an ecological role in protecting plant roots and stem barks from fungal infection. Buddedin A can be used in studies related to fungal infections .
    Buddledin A
  • HY-183764
    COX-2/5-LOX-IN-8

    		COX Lipoxygenase TNF Receptor Interleukin Related MMP Inflammation/Immunology
    COX-2/5-LOX-IN-8 is an orally active dual COX-2/5-LOX inhibitor, with an IC50 of 6.30 μM against sheep-derived COX-2 and an IC50 of 8.09 μM against 5-LOX. COX-2/5-LOX-IN-8 acts as a membrane stabilizer that stabilizes erythrocyte membranes against hypotonicity-induced hemolysis. COX-2/5-LOX-IN-8 functions as a protein stabilizer that inhibits heat-induced denaturation of bovine serum albumin. COX-2/5-LOX-IN-8 reduces paw swelling, improves hind limb weight-bearing function, decreases serum levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, CRP), and lowers serum levels of cartilage degradation biomarkers (COMP, MMP-3, CTX-II). COX-2/5-LOX-IN-8 can be used in the research of osteoarthritis .
    COX-2/5-LOX-IN-8

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