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Cat. No.: HY-124674

CCT365623

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

CCT365623 is a potent and orally active LOX inhibitor with an IC₅₀ of 0.9 μM. CCT365623 has potent anti-metastatic efficacy in vivo.

For research use only. We do not sell to patients.

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Please store the product under the recommended conditions in the Certificate of Analysis.

CAS No.: 2126134-01-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

CCT365623 is a potent and orally active LOX inhibitor with an IC₅₀ of 0.9 μM. CCT365623 has potent anti-metastatic efficacy in vivo^[1].

IC₅₀ & Target

0.9 μM (LOX)

All Lipoxygenase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	13.49 μM Compound: 3a; CCT365623	Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate preincubated for 1 hr followed by substrate addition by ROS-Glo assay Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate preincubated for 1 hr followed by substrate addition by ROS-Glo assay	[PMID: 31430136]
CHO	IC₅₀	48 μM Compound: 9f; CCT365623	Inhibition of recombinant human SSAO expressed in CHO cells by MAO-Glo assay Inhibition of recombinant human SSAO expressed in CHO cells by MAO-Glo assay	[PMID: 31070916]

CAS No. 2126134-01-6
Molecular Weight 407.53
Formula C₁₈H₁₇NO₄S₃
SMILES

NCC1=CC=C(S(=O)(C2=CC(C3=CC=CC=C3)=CC(S(=O)(C)=O)=C2)=O)S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.