COX-2/5-LOX-IN-3
COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual COX-2/5-LOX inhibitor with IC50 values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases.
For research use only. We do not sell to patients.
- CAS No.: 2481484-51-7
- Formula: C17H16ClN3O2S
- Molecular Weight:361.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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5-LOX 4.33 μM (IC50) |
COX-2 5.45 μM (IC50) |
COX-1 45.73 μM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats[1]
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Dosage:2.622 X 10-5 mol/kg
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Administration:Oral administration
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Result:The percentage inhibition of edema (%I) reached 58.77% after 4h.
Chemical Information
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CAS No. 2481484-51-7
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Molecular Weight 361.85
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Formula C17H16ClN3O2S
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SMILES
O=C(NC1=C(C#N)C(C2=CC=C(Cl)C=C2)=CS1)CN3CCOCC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2/5-LOX-IN-3 Related Classifications
HY-147951 Related Classifications
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