COX-2/5-LOX-IN-3
COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual COX-2/5-LOX inhibitor with IC50 values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2481484-51-7
- 分子式: C17H16ClN3O2S
- 分子量:361.85
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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5-LOX 4.33 μM (IC50) |
COX-2 5.45 μM (IC50) |
COX-1 45.73 μM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats[1]
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Dosage:2.622 X 10-5 mol/kg
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Administration:Oral administration
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Result:The percentage inhibition of edema (%I) reached 58.77% after 4h.
化学情報
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CAS 番号 2481484-51-7
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分子量 361.85
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分子式 C17H16ClN3O2S
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SMILES
O=C(NC1=C(C#N)C(C2=CC=C(Cl)C=C2)=CS1)CN3CCOCC3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
COX-2/5-LOX-IN-3 関連分類
HY-147951 関連分類
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