Search Result

Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

SGC cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Akt (1) Apoptosis (12) c-Met/HGFR (1) Calmodulin (1) Casein Kinase (1) CDK (1) CMV (1) Elastase (3) Endogenous Metabolite (2) Environmental Pollutants (2) Epigenetic Reader Domain (1) Guanylate Cyclase (11) Histone Acetyltransferase (1) Histone Methyltransferase (4) HSP (2) Isotope-Labeled Compounds (1) LDLR (1) Lysyl Oxidase (1) Microtubule/Tubulin (3) MMP (1) NF-κB (2) PAK (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5) STAT (1) Wnt (1) YAP (1)
By Research Areas:	Cancer (35) Cardiovascular Disease (9) Infection (1) Inflammation/Immunology (8) Neurological Disease (3)
Oligonucleotides:	Aptamers (2)

Inhibitors & Agonists

Fluorescent Dyes

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15826

SGC-CBP30 Maximum Cited Publications 20 Publications Verification	Epigenetic Reader Domain Histone Acetyltransferase	Inflammation/Immunology Cancer
SGC-CBP30, a chemical probe, is a potent and highly selective CBP/p300 bromodomain (K_ds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects .

HY-112445

SGC3027 5+ Cited Publications	Histone Methyltransferase	Cancer
SGC3027 is a histone methyltransferase inhibitor . SGC3027 is the first potent, selective and cell active chemical probe for PRMT7 .

HY-15650

SGC0946 10+ Cited Publications	Histone Methyltransferase	Cancer
SGC0946 is a selective DOT1L inhibitor with an IC₅₀ value of 0.3 nM. By inhibiting DOT1L, SGC0946 can induce G1 phase arrest, suppress cell self-renewal and metastatic potential, and induce cell differentiation in cancer cells. SGC0946 can be used in the research of tumors such as leukemia and breast cancer, and also serves as a probe to further investigate the cellular mechanisms of DOT1L in normal and diseased cells .

HY-101255

ODQ 10+ Cited Publications	Guanylate Cyclase Apoptosis	Cancer
ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells .

HY-139004

SGC-CK2-1 5 Publications Verification	Casein Kinase	Neurological Disease
SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC₅₀s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases .

HY-W015084

β-Ionone 1 Publications Verification	Environmental Pollutants Apoptosis	Cancer
β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .

HY-111457A

BAY-678 1 Publications Verification	Elastase	Inflammation/Immunology
BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

HY-N2374

Eupatorin 2 Publications Verification	Apoptosis NF-κB MMP Adrenergic Receptor	Inflammation/Immunology Cancer
Eupatorin is an orally active flavonoid with antiproliferative and vasodilatory properties. Eupatorin downregulates the expression levels of NF-κB, MMP9, IL-1β and TNF-α. Eupatorin induces apoptosis, G2/M phase cell cycle arrest, and reactive oxygen species (ROS) production. Eupatorin modulates the activities of muscarinic receptors and β-adrenergic receptors; inhibits sarcoplasmic reticulum calcium release and calcium channels; and activates the NO/sGC/cGMP pathway, indomethacin-sensitive pathway, and potassium channel pathway. Eupatorin exerts cytotoxic effects on cancer cell lines, and is metabolized by CYP1A1 and CYP1 family enzymes to form metabolites with antiproliferative activity. Eupatorin can be used in research related to breast cancer, hypertension, and leukemia .

HY-12379

NS-2028 1 Publications Verification	Guanylate Cyclase	Inflammation/Immunology
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC₅₀ values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity . NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC₅₀ values of 17 nM and 20 nM . NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC₅₀ of 30 nM . NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM) . NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability .

HY-114211

SGC8158	Histone Methyltransferase HSP	Cancer
SGC8158 is an inhibitor of PRMT7 and can be used to study the cellular function of PRMT7. SGC8158 decreases monomethylarginine levels of Hsp70 (the best characterized PRMT7 substrate). SGC8158 induces growth inhibition in various cancer cells (IC₅₀: 2-9 μM), as well as multidrug-resistant (MDR) cancer cells. SGC8158 also enhances Doxorubicin (HY-15142A) induced DNA damage and Its cytotoxicity .

HY-W013386

LY83583 1 Publications Verification	Guanylate Cyclase	Cardiovascular Disease Neurological Disease Cancer
LY83583 is inhibitor of soluble guanylate cyclase (sGC) with the ability to target the cGMP signaling pathway. LY83583 inhibits the kinase activity-related proliferation of tumor cells by inducing the Cdk inhibitor p21. LY83583 can be used for the study of cancers (colorectal cancer, breast cancer and melanoma) and cardiovascular disease .

HY-109066

Olinciguat 1 Publications Verification IW-1701	Guanylate Cyclase	Cardiovascular Disease
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay .

HY-W015084A

(E)-β-Ionone β-Lonone	Environmental Pollutants Apoptosis	Cancer
(E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .

HY-153708

SGC-CLK-1 CAF-170	CDK	Cancer
SGC-CLK-1, a chemical probe, is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. SGC-CLK-1 can inhibit the growth of melanoma and glioblastoma cells .

HY-155360

MY-1076 1 Publications Verification	YAP Apoptosis	Cancer
MY-1076 is an inhibitor of YAP. MY-1076 induces YAP degradation and cell apoptosis. MY-1076 inhibits MGC-803, SGC-7901, HCT-116 and KYSE450 cells proliferation with IC₅₀ s of 0.019, 0.017, 0.020 and 0.044 μM, respectively .

HY-168905

SGC-CAMKK2-1	Calmodulin	Cancer
SGC-CAMKK2-1, a chemical probe, is the selective, inhibitor for calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC₅₀ of 30 nM. SGC-CAMKK2-1 inhibits AMPK phosphorylation in cell C4-2 with an IC₅₀ of 1.6 μM .

HY-178335

SGC-CK1γ-1	LDLR Wnt CMV	Infection
SGC-CK1γ-1 is a potent and selective probe for the CK1γ subfamily. SGC-CK1γ-1 can inhibit LRP6 phosphorylation levels. SGC-CK1γ-1 can selectively inhibit the CK1γ kinases in living cells and inhibit both WNT signaling and human cytomegalovirus (CMV) replication. SGC-CK1γ-1 can be used for the research of infection .

HY-117917

(Rac)-MGV354	Guanylate Cyclase	Cardiovascular Disease Inflammation/Immunology
(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC₅₀s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively .

HY-N7980

Rubipodanone A	NF-κB	Cancer
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-111515

BAY-678 racemate	Elastase	Inflammation/Immunology
BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

HY-111457

BAY-677 1 Publications Verification	Elastase	Inflammation/Immunology
BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM . BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC) .

HY-124398

GL-1196	PAK	Cancer
GL-1196 is an inhibitor of PAK4. GL-1196 can suppress the proliferation and invasion of gastric cancer cells. GL-1196 inhibits PAK4-mediated signaling pathways. GL-1196 can hinder the proliferation of human gastric cancer cells through suppressing PAK4/c-Src/EGFR/CyclinD1 and CDK4/6. GL-1196 can reduce filamentous pseudopodia formation and induce filamentous pseudopodia formation and promote cell elongation in SGC7901 and BGC823 cells. GL-1196 can be studied in anti-cancer research .

HY-W013386R

LY83583 (Standard)	Reference Standards Guanylate Cyclase	Cardiovascular Disease Neurological Disease Cancer
LY83583 (Standard) is the analytical standard of LY83583 (HY-W013386). This product is intended for research and analytical applications. LY83583 is inhibitor of soluble guanylate cyclase (sGC) with the ability to target the cGMP signaling pathway. LY83583 inhibits the kinase activity-related proliferation of tumor cells by inducing the Cdk inhibitor p21. LY83583 can be used for the study of cancers (colorectal cancer, breast cancer and melanoma) and cardiovascular disease .

HY-142697

SGC agonist 1	Guanylate Cyclase	Cardiovascular Disease
SGC agonist 1 is a potent agonist of soluble guanylate cyclase (SGC). SGC agonist 1 improves solubility combined with high cell permeability. SGC agonist 1 has the potential for the research of cardiovascular disease (extracted from patent WO2016030354A1, compound 18A) .

HY-159484

Hsp110/sGC-modulator-1	HSP Guanylate Cyclase	Cardiovascular Disease
Hsp110/sGC-modulator-1 (compound 17i), an orally active *Hsp110/sGC* dual-target regulator, exhibits optimal Hsp110 and sGC molecular activities as well as remarkable cell malignant phenotypes inhibitory and vasodilatory effects. Hsp110/sGC-modulator-1 (compound 17i) attenuates pulmonary vascular remodeling and right ventricular hypertrophy via Hsp110 suppression .

HY-N10201

Cytoglobosin C	Endogenous Metabolite	Cancer
Cytoglobosin C, a cytochalasan derivative, shows potent cytotoxicity against both SGC-7901 and A549 cell lines (IC₅₀<10 μM) .

HY-15650A

SGC0946 TFA	Histone Methyltransferase	Cancer
SGC0946 TFA is a selective DOT1L inhibitor with an IC₅₀ value of 0.3 nM. By inhibiting DOT1L, SGC0946 TFA can induce G1 phase arrest, suppress cell self-renewal and metastatic potential, and induce cell differentiation in cancer cells. SGC0946 TFA can be used in the research of tumors such as leukemia and breast cancer, and also serves as a probe to further investigate the cellular mechanisms of DOT1L in normal and diseased cells .

HY-161351

STAT3/AKT-IN-1	Akt STAT Apoptosis	Cancer
STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells .

HY-N1841

Rocaglamide D 3'-Hydroxyrocaglamide	Others	Cancer
Rocaglamide D (3'-Hydroxyrocaglamide) (compound 1) is a lignan that can be found in Aglaia odorata. Rocaglamide D shows cytotoxicity with IC₅₀s of 0.32, 0.12, 0.25 µM for HeLa, SGC-7901, A549 cells, respectively .

HY-146311

Tubulin polymerization-IN-16	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC₅₀ values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells .

HY-156098

c-Met-IN-19	c-Met/HGFR	Cancer
c-Met-IN-19 (Compound 21j) is a c-Met inhibitor (IC₅₀: 1.99 nM). c-Met-IN-19 shows cytotoxicity against A549, HT-29, SGC-7901, MDA-MB-231 cells with IC₅₀s of 0.25, 0.36, 0.98, 0.76 μM .

HY-111516

MGV354	Guanylate Cyclase	Cardiovascular Disease Inflammation/Immunology
MGV354 is a soluble guanylate cyclase (sGC) activator with EC₅₀s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively .

HY-176162

BJ-13	Reactive Oxygen Species (ROS) Apoptosis	Cancer
BJ-13 is a reactive oxygen species (ROS) inducer that can lead to mitochondrial membrane potential collapse and caspase-dependent apoptosis. BJ-13 inhibits the proliferation of SGC-7901, U-87MG, and HepG-2 cancer cells (IC₅₀ values of 15.33, 27.18, and 20.44 nM, respectively). BJ-13 can be used in the study of gastric cancer .

HY-147947

Tubulin polymerization-IN-30	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-30 (compound 6e) is a potent Tubulin polymerization inhibitor. Tubulin polymerization-IN-30 is a colchicine binding site inhibitor. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including SGC-7901, A549 and HeLa, with IC₅₀ values of 2.16, 2.21, and 0.403 μM .

HY-168102

Antiproliferative agent-59	Microtubule/Tubulin Apoptosis	Cancer
Antiproliferative agent-59 (Compound 14u) is an inhibitor for tubulin polymerization. Antiproliferative agent-59 exhibits antiproliferative activities against cancer cells Huh7, SGC-7901, and MCF-7 with IC₅₀ of 0.03, 0.18, and 0.13μM. Antiproliferative agent-59 arrests the cell cycle at G2/M phase and induces apoptosis in Huh7 cell. Antiproliferative agent-59 exhibits antitumor efficacy against liver cancer in Huh7 xenograft mouse models, without significant toxicity .

HY-W015084S

β-Ionone-13C3	Isotope-Labeled Compounds Apoptosis	Cancer
β-Ionone- ¹³C₃ is the ¹³C-labeled β-Ionone. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .

HY-W015084R

β-Ionone (Standard)	Reference Standards Apoptosis	Cancer
β-Ionone (Standard) is the analytical standard of β-Ionone. This product is intended for research and analytical applications. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .

HY-101255R

ODQ (Standard)	Reference Standards Guanylate Cyclase Apoptosis	Cancer
ODQ (Standard) is the analytical standard of ODQ. This product is intended for research and analytical applications. ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells .

HY-N13136

Timosaponin D	Others	Cancer
Timosaponin D, a natural steroid saponin, can be obtained from the rhizome of Anemarrhena asphodeloides. The IC₅₀ values of Timosaponin D against HepG2 and SGC7901 cells are 43.90 and 57.90 μM, respectively. Timosaponin D can be used in anticancer research .

HY-W015084AR

(E)-β-Ionone (Standard) β-Lonone (Standard)	Apoptosis Reference Standards	Cancer
(E)-β-Ionone (Standard) is the analytical standard of (E)-β-Ionone. This product is intended for research and analytical applications. (E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .

HY-109066R

Olinciguat (Standard) IW-1701 (Standard)	Reference Standards Guanylate Cyclase	Cardiovascular Disease
Olinciguat (Standard) is the analytical standard of Olinciguat (HY-109066). This product is intended for research and analytical applications. Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay .

HY-N17005

3-O-(p-Hydroxybenzoyl)serratriol	Others	Cancer
3-O-(p-Hydroxybenzoyl)serratriol is a serratene-type triterpenoid compound with low cytotoxicity against cancer cells (IC₅₀ >100 μg/mL against three human cancer cell lines: K562, SMMC-7721, and SGC7901). 3-O-(p-Hydroxybenzoyl)serratriol can be naturally extracted from the whole plant of Palhinhaea cernua .

HY-N17852

3-O-Arabinopyranosyl siaresinolic acid	Others	Cancer
3-O-Arabinopyranosyl siaresinolic acid is a triterpenoid found in the roots of Sanguisorba officinalis. 3-O-Arabinopyranosyl siaresinolic acid shows no activity against cancer cells .

HY-183644

LNO 9	Lysyl Oxidase	Cardiovascular Disease
LNO 9 is an orally active LOXL2 inhibitor and NO donor, with an IC₅₀ of 0.17 μM against human LOXL2. LNO 9 competitively binds to the LTQ cofactor of LOXL2 to form an irreversible complex, thereby inhibiting collagen oxidation and abnormal cross-linking. LNO 9 releases nitric oxide (NO) to increase cGMP levels in pulmonary artery smooth muscle cells. LNO 9 inhibits hypoxia-induced collagen modification and possesses vasodilatory activity. LNO 9 ameliorates right ventricular hypertrophy and pulmonary artery medial thickness in rat models induced by hypoxia and Monocrotaline (HY-N0750), and can be used for research on pulmonary hypertension .

HY-N17349

(23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol	Endogenous Metabolite	Cancer
(23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol (compound 3) is a cytotoxin that can be found in the marine bryozoan Bugula neritina. (23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol shows weak cytotoxicity against SGC7901 cell with an IC₅₀ value of 111.8 μM. (23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol can be used for the research of hepatocellular carcinoma, gastric carcinoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015084

β-Ionone 1 Publications Verification	Structural Classification Classification of Application Fields Viola odorata Linn. Ketones, Aldehydes, Acids Violaceae Plants Disease Research Fields Source Classification Cancer	Environmental Pollutants Apoptosis
β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .

HY-N2374

Eupatorin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Source Classification Cancer	Apoptosis NF-κB MMP Adrenergic Receptor
Eupatorin is an orally active flavonoid with antiproliferative and vasodilatory properties. Eupatorin downregulates the expression levels of NF-κB, MMP9, IL-1β and TNF-α. Eupatorin induces apoptosis, G2/M phase cell cycle arrest, and reactive oxygen species (ROS) production. Eupatorin modulates the activities of muscarinic receptors and β-adrenergic receptors; inhibits sarcoplasmic reticulum calcium release and calcium channels; and activates the NO/sGC/cGMP pathway, indomethacin-sensitive pathway, and potassium channel pathway. Eupatorin exerts cytotoxic effects on cancer cell lines, and is metabolized by CYP1A1 and CYP1 family enzymes to form metabolites with antiproliferative activity. Eupatorin can be used in research related to breast cancer, hypertension, and leukemia .

HY-W015084A

(E)-β-Ionone β-Lonone	Structural Classification Viola odorata Linn. Terpenoids Sesquiterpenes Violaceae Plants Source Classification	Environmental Pollutants Apoptosis
(E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .

HY-N7980

Rubipodanone A	Quinones Classification of Application Fields Rubia podantha Rubiaceae Plants Naphthalene Quinones Disease Research Fields Source Classification Cancer	NF-κB
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-N10201

Cytoglobosin C	Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Indole Alkaloids Cancer Source Classification	Endogenous Metabolite
Cytoglobosin C, a cytochalasan derivative, shows potent cytotoxicity against both SGC-7901 and A549 cell lines (IC₅₀<10 μM) .

HY-N1841

Rocaglamide D 3'-Hydroxyrocaglamide	Lignans Aglaia odorata Lour. Phenylpropanoids Plants Meliaceae Source Classification	Others
Rocaglamide D (3'-Hydroxyrocaglamide) (compound 1) is a lignan that can be found in Aglaia odorata. Rocaglamide D shows cytotoxicity with IC₅₀s of 0.32, 0.12, 0.25 µM for HeLa, SGC-7901, A549 cells, respectively .

HY-W015084R

β-Ionone (Standard)	Structural Classification Viola odorata Linn. Ketones, Aldehydes, Acids Violaceae Plants Source Classification	Reference Standards Apoptosis
β-Ionone (Standard) is the analytical standard of β-Ionone. This product is intended for research and analytical applications. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .

HY-N13136

Timosaponin D	Triterpenes Liliaceae Terpenoids Anemarrhena asphodeloides Bunge Plants Source Classification	Others
Timosaponin D, a natural steroid saponin, can be obtained from the rhizome of Anemarrhena asphodeloides. The IC₅₀ values of Timosaponin D against HepG2 and SGC7901 cells are 43.90 and 57.90 μM, respectively. Timosaponin D can be used in anticancer research .

HY-W015084AR

(E)-β-Ionone (Standard) β-Lonone (Standard)	Structural Classification Microorganisms Viola odorata Linn. Terpenoids Sesquiterpenes Violaceae Plants Source Classification	Apoptosis Reference Standards
(E)-β-Ionone (Standard) is the analytical standard of (E)-β-Ionone. This product is intended for research and analytical applications. (E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .

HY-N17005

3-O-(p-Hydroxybenzoyl)serratriol	Lycopodiaceae Structural Classification Palhinhaea cernua (L.) Vasc. & Franco Terpenoids Phenols Plants Pentacyclic Triterpenoids Source Classification	Others
3-O-(p-Hydroxybenzoyl)serratriol is a serratene-type triterpenoid compound with low cytotoxicity against cancer cells (IC₅₀ >100 μg/mL against three human cancer cell lines: K562, SMMC-7721, and SGC7901). 3-O-(p-Hydroxybenzoyl)serratriol can be naturally extracted from the whole plant of Palhinhaea cernua .

HY-N17852

3-O-Arabinopyranosyl siaresinolic acid	Structural Classification Sanguisorba officinalis Linn. Terpenoids Rosaceae Plants Pentacyclic Triterpenoids Source Classification	Others
3-O-Arabinopyranosyl siaresinolic acid is a triterpenoid found in the roots of Sanguisorba officinalis. 3-O-Arabinopyranosyl siaresinolic acid shows no activity against cancer cells .

HY-N17349

(23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol	Structural Classification Tetracyclic Triterpenoids Animals Terpenoids Source Classification	Endogenous Metabolite
(23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol (compound 3) is a cytotoxin that can be found in the marine bryozoan Bugula neritina. (23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol shows weak cytotoxicity against SGC7901 cell with an IC₅₀ value of 111.8 μM. (23S,24R)-Dimethylcholest-7-ene-3b,5a,6b-triol can be used for the research of hepatocellular carcinoma, gastric carcinoma .

Cat. No.	Product Name	Chemical Structure

HY-W015084S

β-Ionone-13C3
β-Ionone- ¹³C₃ is the ¹³C-labeled β-Ionone. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .

Cat. No.	Product Name		Classification

HY-177571

Sgc8c-M SGC8c-VcMMAE		Aptamers
Sgc8c-M is a PTK7-targeted aptamer-drug conjugate (ApDC). Sgc8c-M is composed of the classic PTK7-specific aptamer Sgc8c, a cathepsin B (CTSB)-cleavable valine-citrulline (VC)-based linker, and the potent antimitotic agent Monomethyl auristatin E (MMAE) (HY-15162) as the payload. Sgc8c-M inhibits the growth of PTK7-overexpressing cancer cells. Sgc8c-M can be used for the study of PTK7-expressing advanced solid tumors .

HY-160065

sgc8c aptamer sodium		Aptamers
sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase PTK-7, which is mainly expressed on cervical cancer HeLa cells. sgc8c aptamer sodium can precisely bring the nanotags connected to it to the surface of cells expressing PTK-7, thus achieving specific recognition and labeling of target cells .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

SGC cells

Inhibitors & Agonists

Fluorescent Dyes

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products