GL-1196
GL-1196 is an inhibitor of PAK4. GL-1196 can suppress the proliferation and invasion of gastric cancer cells. GL-1196 inhibits PAK4-mediated signaling pathways. GL-1196 can hinder the proliferation of human gastric cancer cells through suppressing PAK4/c-Src/EGFR/CyclinD1 and CDK4/6. GL-1196 can reduce filamentous pseudopodia formation and induce filamentous pseudopodia formation and promote cell elongation in SGC7901 and BGC823 cells. GL-1196 can be studied in anti-cancer research.
For research use only. We do not sell to patients.
- CAS No.: 591242-70-5
- Formula: C20H15ClN2O3S
- Molecular Weight:398.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 591242-70-5
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Molecular Weight 398.86
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Formula C20H15ClN2O3S
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SMILES
O=S1(N=C(N(CC2=C(O)C=CC=C2)C3=CC=C(C=C3)Cl)C4=C1C=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Huang, G., et al., (2025). P21-activated kinase 4: a potent oncogene, molecular mechanisms and opportunities for targeted therapy. Cancer cell international, 25(1), 409. [Content Brief]
[2]. Zhang, J., et al., (2024). Correction: Zhang et al. GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways. Int. J. Mol. Sci. 2016, 17, 470. International journal of molecular sciences, 25(24), 13456. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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