591242-70-5
Chemical Structure
GL-1196
- CAS No.: 591242-70-5
- Formula:C20H15ClN2O3S
- Molecular Weight:398.86
IUPAC Name: 3-((4-chlorophenyl)(2-hydroxybenzyl)amino)benzo[d]isothiazole 1,1-dioxide
InChIKey: CZVJDJNGXBOBKM-UHFFFAOYSA-N
SMILES: O=S1(N=C(N(CC2=C(O)C=CC=C2)C3=CC=C(C=C3)Cl)C4=C1C=CC=C4)=O
Biological Activity: GL-1196 is an inhibitor of PAK4. GL-1196 can suppress the proliferation and invasion of gastric cancer cells. GL-1196 inhibits PAK4-mediated signaling pathways. GL-1196 can hinder the proliferation of human gastric cancer cells through suppressing PAK4/c-Src/EGFR/CyclinD1 and CDK4/6. GL-1196 can reduce filamentous pseudopodia formation and induce filamentous pseudopodia formation and promote cell elongation in SGC7901 and BGC823 cells. GL-1196 can be studied in anti-cancer research[1][2].
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GL-1196 | GL-1196 is an inhibitor of PAK4. GL-1196 can suppress the proliferation and invasion of gastric cancer cells. GL-1196 inhibits PAK4-mediated signaling pathways. GL-1196 can hinder the proliferation of human gastric cancer cells through suppressing PAK4/c-Src/EGFR/CyclinD1 and CDK4/6. GL-1196 can reduce filamentous pseudopodia formation and induce filamentous pseudopodia formation and promote cell elongation in SGC7901 and BGC823 cells. GL-1196 can be studied in anti-cancer research. | |||||||||||||||||||||
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References
- [1]. Huang, G., et al., (2025). P21-activated kinase 4: a potent oncogene, molecular mechanisms and opportunities for targeted therapy. Cancer cell international, 25(1), 409. [Content Brief]
- [2]. Zhang, J., et al., (2024). Correction: Zhang et al. GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways. Int. J. Mol. Sci. 2016, 17, 470. International journal of molecular sciences, 25(24), 13456. [Content Brief]
