1. GPCR/G Protein
    Apoptosis
  2. Guanylate Cyclase
    Apoptosis
  3. ODQ

ODQ 

Cat. No.: HY-101255 Purity: 99.52%
Handling Instructions

ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells.

For research use only. We do not sell to patients.

ODQ Chemical Structure

ODQ Chemical Structure

CAS No. : 41443-28-1

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10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 185 In-stock
Estimated Time of Arrival: December 31
50 mg USD 280 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells[1].

In Vitro

At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM[1].

In Vivo

ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat[2].

Animal Model: Anesthetized, male Wistar rats[2]
Dosage: 2 mg/kg
Administration: I.p.
Result: Attenuated the renal dysfunction, lung injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide.
Molecular Weight

187.15

Formula

C₉H₅N₃O₂

CAS No.

41443-28-1

SMILES

O=C1ON=C2N1C3=C(C=CC=C3)N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (534.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3433 mL 26.7165 mL 53.4331 mL
5 mM 1.0687 mL 5.3433 mL 10.6866 mL
10 mM 0.5343 mL 2.6717 mL 5.3433 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (26.72 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.52%

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Keywords:

ODQGuanylate CyclaseApoptosisselectiveorganinjurydysfunctionmesotheliomacellsInhibitorinhibitorinhibit

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ODQ
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HY-101255
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