1. GPCR/G Protein
  2. Guanylate Cyclase
  3. MGV354


Cat. No.: HY-111516
Handling Instructions

MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.

For research use only. We do not sell to patients.

MGV354 Chemical Structure

MGV354 Chemical Structure

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MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively[1][2].

IC50 & Target

soluble guanylate cyclase[1][2]

In Vitro

MGV354 (0.1 nM-10 μM) treatment for 1 hour causes a dose-dependent increase in cGMP levels in normal human trabecular meshwork (NTM) cells (average EC50=2.5±1.6 nM) following treatment with ODQ (20 μM). The average cGMP produced by MGV354 in human NTM cells is 46±28 nM. MGV354 (1 μM) causes a linear increase in intracellular cGMP levels in a time-dependent manner (assay conditions up to 3 hours) in NTM cells[3].

In Vivo

MGV354 (Compound (+)-23) robustly lowers intraocular pressure in a cynomolgus model of elevated intraocular pressure over 24 h after a single topical ocular drop[1].

Clinical Trial
Molecular Weight





O=C(C1=C(C)N(C2=NC(C3=CC=CC4=C3[[email protected]@H](NC5=CC=C(C6CCN(C(C7CC7)=O)CC6)C=C5C)CC4)=CC=C2)N=C1)O


Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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MGV354MGV 354MGV-354Guanylate CyclasesGCactivatorintraocularpressuretopicaloculardropInhibitorinhibitorinhibit

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