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  4. BAY-677

BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

For research use only. We do not sell to patients.

BAY-677 Chemical Structure

BAY-677 Chemical Structure

CAS No. : 2117404-84-7

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 77 In-stock
Solid
5 mg USD 70 In-stock
10 mg USD 120 In-stock
25 mg USD 260 In-stock
50 mg USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM[1]. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC)[2].

Molecular Weight

400.35

Formula

C20H15F3N4O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=NC=C([C@@H](C(C(C)=O)=C(C)N2C3=CC=CC(C(F)(F)F)=C3)NC2=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (124.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4978 mL 12.4891 mL 24.9781 mL
5 mM 0.4996 mL 2.4978 mL 4.9956 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4978 mL 12.4891 mL 24.9781 mL 62.4454 mL
5 mM 0.4996 mL 2.4978 mL 4.9956 mL 12.4891 mL
10 mM 0.2498 mL 1.2489 mL 2.4978 mL 6.2445 mL
15 mM 0.1665 mL 0.8326 mL 1.6652 mL 4.1630 mL
20 mM 0.1249 mL 0.6245 mL 1.2489 mL 3.1223 mL
25 mM 0.0999 mL 0.4996 mL 0.9991 mL 2.4978 mL
30 mM 0.0833 mL 0.4163 mL 0.8326 mL 2.0815 mL
40 mM 0.0624 mL 0.3122 mL 0.6245 mL 1.5611 mL
50 mM 0.0500 mL 0.2498 mL 0.4996 mL 1.2489 mL
60 mM 0.0416 mL 0.2082 mL 0.4163 mL 1.0408 mL
80 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7806 mL
100 mM 0.0250 mL 0.1249 mL 0.2498 mL 0.6245 mL
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BAY-677 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-6772117404-84-7BAY677BAY 677OthersInhibitorinhibitorinhibit

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