BAY-677
Based on 1 publication(s) in Google Scholar
BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
For research use only. We do not sell to patients.
- Purity: 97.68%
- CAS No.: 2117404-84-7
- Formula: C20H15F3N4O2
- Molecular Weight:400.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
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Orally Active Compound Library
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Publications Citing Use of MedChemExpress (MCE) BAY-677
More
Biological Activity
Chemical Information
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CAS No. 2117404-84-7
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Appearance Solid
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Molecular Weight 400.35
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Formula C20H15F3N4O2
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Color Light yellow to yellow
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SMILES
N#CC1=NC=C([C@@H](C(C(C)=O)=C(C)N2C3=CC=CC(C(F)(F)F)=C3)NC2=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175
Solvent & Solubility
DMSO : ≥ 50 mg/mL (124.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73.. [Content Brief]
[2]. von Nussbaum F, et al. Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4370-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4978 mL | 12.4891 mL | 24.9781 mL | 62.4454 mL |
| 5 mM | 0.4996 mL | 2.4978 mL | 4.9956 mL | 12.4891 mL | |
| 10 mM | 0.2498 mL | 1.2489 mL | 2.4978 mL | 6.2445 mL | |
| 15 mM | 0.1665 mL | 0.8326 mL | 1.6652 mL | 4.1630 mL | |
| 20 mM | 0.1249 mL | 0.6245 mL | 1.2489 mL | 3.1223 mL | |
| 25 mM | 0.0999 mL | 0.4996 mL | 0.9991 mL | 2.4978 mL | |
| 30 mM | 0.0833 mL | 0.4163 mL | 0.8326 mL | 2.0815 mL | |
| 40 mM | 0.0624 mL | 0.3122 mL | 0.6245 mL | 1.5611 mL | |
| 50 mM | 0.0500 mL | 0.2498 mL | 0.4996 mL | 1.2489 mL | |
| 60 mM | 0.0416 mL | 0.2082 mL | 0.4163 mL | 1.0408 mL | |
| 80 mM | 0.0312 mL | 0.1561 mL | 0.3122 mL | 0.7806 mL | |
| 100 mM | 0.0250 mL | 0.1249 mL | 0.2498 mL | 0.6245 mL |
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