BAY-677
Based on 1 publication(s) in Google Scholar
BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.68%
- CAS 番号: 2117404-84-7
- 分子式: C20H15F3N4O2
- 分子量:400.35
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 BAY-677
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生物活性
化学情報
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CAS 番号 2117404-84-7
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性状 Solid
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分子量 400.35
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分子式 C20H15F3N4O2
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Color Light yellow to yellow
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SMILES
N#CC1=NC=C([C@@H](C(C(C)=O)=C(C)N2C3=CC=CC(C(F)(F)F)=C3)NC2=O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175
溶剤 & 溶解度
DMSO : ≥ 50 mg/mL (124.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73.. [Content Brief]
[2]. von Nussbaum F, et al. Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4370-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4978 mL | 12.4891 mL | 24.9781 mL | 62.4454 mL |
| 5 mM | 0.4996 mL | 2.4978 mL | 4.9956 mL | 12.4891 mL | |
| 10 mM | 0.2498 mL | 1.2489 mL | 2.4978 mL | 6.2445 mL | |
| 15 mM | 0.1665 mL | 0.8326 mL | 1.6652 mL | 4.1630 mL | |
| 20 mM | 0.1249 mL | 0.6245 mL | 1.2489 mL | 3.1223 mL | |
| 25 mM | 0.0999 mL | 0.4996 mL | 0.9991 mL | 2.4978 mL | |
| 30 mM | 0.0833 mL | 0.4163 mL | 0.8326 mL | 2.0815 mL | |
| 40 mM | 0.0624 mL | 0.3122 mL | 0.6245 mL | 1.5611 mL | |
| 50 mM | 0.0500 mL | 0.2498 mL | 0.4996 mL | 1.2489 mL | |
| 60 mM | 0.0416 mL | 0.2082 mL | 0.4163 mL | 1.0408 mL | |
| 80 mM | 0.0312 mL | 0.1561 mL | 0.3122 mL | 0.7806 mL | |
| 100 mM | 0.0250 mL | 0.1249 mL | 0.2498 mL | 0.6245 mL |
BAY-677 関連分類
HY-111457 関連分類
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