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Results for "

acidic conditions

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) ADC Payload (2) Amino Acid Derivatives (1) Amyloid-β (1) Apoptosis (9) ASCT (1) Autophagy (9) Bacterial (2) Biochemical Assay Reagents (69) Cannabinoid Receptor (1) Cathepsin (1) Collagen (1) Drug Derivative (1) Drug Intermediate (3) Drug Isomer (1) Drug Metabolite (6) E3 Ligase Ligand-Linker Conjugates (15) Endogenous Metabolite (3) Environmental Pollutants (2) Ferroptosis (2) Fluorescent Dye (14) Fungal (2) Glutathione Peroxidase (1) GPR65 (1) Herbicide (1) HyT (1) Insulin Receptor (1) Ligands for E3 Ligase (4) Lipase (1) MAPKAPK2 (MK2) (1) Neuropeptide Y Receptor (2) NO Synthase (2) PAK (1) Parasite (1) PD-1/PD-L1 (1) PDGFR (1) PROTAC Linkers (10) Reactive Oxygen Species (ROS) (1) Reference Standards (4) Sodium Channel (2) Topoisomerase (2)
By Research Areas:	Cancer (43) Cardiovascular Disease (4) Infection (3) Inflammation/Immunology (6) Metabolic Disease (9) Neurological Disease (5)
Click Chemistry:	DBCO (1) Azide (1)

149

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0715

Fluorescamine 1 Publications Verification Ro 20-7234	Fluorescent Dye	Others
Fluorescamine is a spirocyclic compound that is non-fluorescent. Fluorescamine reacts rapidly with primary amine groups in proteins under alkaline conditions to generate products with strong fluorescence (Ex/Em: 390/475 nm). Fluorescamine can be used to detect amine-containing compounds, including amino acids, peptides, and proteins .

HY-16261

Aldoxorubicin Maximum Cited Publications 21 Publications Verification INNO-206; DOXO-EMCH	Topoisomerase ADC Payload	Cancer
Aldoxorubicin (INNO-206) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models.

HY-N7495

all-trans-Anhydro Retinol Anhydrovitamin A	Drug Metabolite	Metabolic Disease
all-trans-Anhydro Retinol (Anhydrovitamin A) is an orally active degradation product formed by the dehydration of vitamin A alcohol and its esters under conditions such as acidic catalysis or hydroxylic solvents, with a biological activity only 0.4% of that of Vitamin A (HY-B1342). In rats, all-trans-Anhydro Retinol can be metabolized into hydroxy derivatives and their esters, but it cannot be converted into Vitamin A (HY-B1342) and has a low storage capacity in the body .

HY-W040256

Acid phosphatase, wheat ACP	Endogenous Metabolite	Metabolic Disease Cancer
Acid phosphatase, wheat (ACP) is a hydrolase enzyme found in wheat. Acid phosphatase, wheat catalyses the hydrolysis of orthophosphate monoesters under acidic conditions .

HY-40228

(R)-(+)-tert-Butylsulfinamide (R)-2-Methylpropane-2-sulfinamide	Biochemical Assay Reagents	Others
(R)-(+)-tert-Butylsulfinamide ((R)-2-Methylpropane-2-sulfinamide) is a chiral reagent commonly used in the asymmetric synthesis of compounds such as amines, amino acids, and amino alcohols. (R)-(+)-tert-Butylsulfinamide achieves stereoselective reactions by condensing with carbonyl groups to form sulfinyl imine intermediates, and after the reaction, this group can be removed under acidic conditions to obtain the target product .

HY-W019927

Ammonium iron(III) sulfate dodecahydrate, 99% Ammonium ferric sulfate dodecahydrate, 99%	Biochemical Assay Reagents	Others
Ammonium iron(III) sulfate dodecahydrate, 99% is an analytical reagent-grade iron(III) salt and source material for iron(III) reagent or standard solutions in volumetric analysis .

HY-29035

Dopamine acrylamide	Collagen	Others
Dopamine acrylamide, a polyphenol derivative, can cross-link collagen mainly via noncovalent bonding under acidic-non-oxidized conditions .

HY-W088068

Wright's stain	Fluorescent Dye	Others
Wright's stain is a composite cell stain that mainly binds to intracellular nucleic acids, proteins and other components through thiazine dyes (such as methylene blue) and eosin. Wright's stain is pH-dependent (optimal pH 6.4-6.7) and achieves cell morphology resolution by differentially staining the cytoplasm and nucleus. Under alkaline conditions, thiazine dyes bind to nucleic acids to form purple, and acidic eosin binds to cytoplasmic proteins to form red, which can form contrasting cell morphological features. Wright's stain can clearly display the fine structures of blood cells and bone marrow cells (such as nuclear chromatin and granules) and quickly evaluate cell morphological abnormalities .

HY-W923198

Fluorescein O-methacrylate Methacryloyloxy fluorescein	Fluorescent Dye	Others
Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-responsive fluorescent monomeric dye. Fluorescein O-methacrylate exhibits pH-responsive fluorescence properties: its fluorescence is activated under alkaline conditions and quenched under neutral or acidic conditions; reversible switching of fluorescence is achievable by adjusting the pH of the solution. Fluorescein O-methacrylate can be used as a monomer for the synthesis of amphiphilic fluorescein polymers. These polymers can self-assemble into stable polymer nanoparticles with enhanced aqueous-phase fluorescence, and also enable the conjugation of nanoparticles with amine-containing biomolecules to support sensitive optical detection of biomarkers (Ex/Em = 490/520 nm) .

HY-Y0469

1-Aminohydantoin hydrochloride 1 Publications Verification	Drug Metabolite	Others
1-Aminohydantoin hydrochloride is a major metabolite of nitrofurantoin in animal tissues and can be used as a standard for the determination of residues of veterinary agents in meat, milk et.al. 1-Aminohydantoin hydrochloride covalently binds to tissue proteins and is released from the tissues under slightly acidic conditions and derivatized with 2-nitrobenzaldehyde to form nitrophenyl derivatives of AHD before detection .

HY-139005

BODIPY aminoacetaldehyde diethyl acetal BAAA-DA	Fluorescent Dye	Others
BODIPY aminoacetaldehyde diethyl acetal is a stable precursor to BODIPY-aminoacetaldehyde and can be converted into BODIPY-aminoacetaldehyde under acidic conditions. BODIPY-aminoacetaldehyde is a fluorescent substrate for aldehyde dehydrogenase (ALDH) .

HY-138540

1-Dodecylimidazole 3 Publications Verification N-Dodecylimidazole	Fungal	Cancer
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .

HY-42773

tert-Butyl (8-aminooctyl)carbamate 1-Boc-1,8-diaminooctane	PROTAC Linkers	Cancer
tert-Butyl (8-aminooctyl)carbamate (1-Boc-1,8-diaminooctane) can be used as a PROTAC linker in the synthesis of PROTACs. tert-butyl (8-aminooctyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W052066

tert-Butyl (3-chloropropyl)carbamate	Biochemical Assay Reagents	Others
tert-Butyl (3-chloropropyl)carbamate is a compound with a t-butyl and a terminal choloride. The cholorine (Cl) is a good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W460072

tert-Butyl 7-hydroxyheptanoate	Biochemical Assay Reagents	Others
tert-Butyl 7-hydroxyheptanoate is a linker with a hydroxyl group and a t-butyl ester. The hydroxyl group allows for further derivatization or replacement with many other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

HY-W047688

tert-Butyl (10-aminodecyl)carbamate 1-Boc-1,10-diaminodecane	PROTAC Linkers	Cancer
tert-Butyl (10-aminodecyl) carbamate (1-Boc-1,10-diaminodecane) is a synthetic intermediate that serves as a PROTAC linker in PROTAC synthesis and other conjugation applications. tert-Butyl (10-aminodecyl) carbamate is an alkane chain with a terminal amine and a Boc-protected amino group. The amine group can react with carboxylic acids, active NHS esters, carbonyl groups (ketones, aldehydes), etc. The Boc group can be deprotected under mild acidic conditions to form a free amine .

HY-P5174

MitTx	Sodium Channel	Neurological Disease
MitTx is a complex formed by MitTx-α and MitTx-β. MitTx is an ASIC1 channel activator with EC₅₀ values of 9.4 and 23 nM for ASIC1a and ASIC1b isoforms, respectively. MitTx is highly selective for ASIC1 isoforms at neutral pH. Under acidic conditions, MitTx greatly enhances proton-evoked ASIC2a channel activation .

HY-Y1361

Diethyl D-(-)-tartrate D-(-)-Tartaric acid diethyl ester	Biochemical Assay Reagents Drug Intermediate	Others
Diethyl D-(-)-tartrate (D-(-)-Tartaric acid diethyl ester) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Diethyl D(-)-tartrate can also react with fatty carbonyl compounds to form bis(sodium carboxylate) types of surfactants, which have good water solubility, strong ability to lower surface tension, and can be easily decomposed under acidic conditions .

HY-W717548

Safinamide acid	Drug Metabolite	Others
Safinamide acid (Compound Imp-E) is the metabolite of Safinamide (HY-70057). Safinamide acid can be formed by hydrolysis of Safinamide intermediate under alkaline or acidic conditions. Safinamide acid is utilized to monitor process-related impurities and degradation products in safinamide samples .

HY-W039729

5-(Boc-amino)-1-pentanol	Biochemical Assay Reagents	Others
5-(Boc-amino)-1-pentanol is a linker containing a hydroxyl group and Boc-protected amino group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W250143

Toluidine blue (ZnCl2)	Biochemical Assay Reagents	Others
Toluidine blue (ZnCl2) is a basic thiazine dye commonly used as a biological stain for microscopy. It has a deep bluish-purple color and is commonly used to stain nucleic acids such as DNA and RNA, as well as to stain mast cells, cartilage, and other connective tissues. Toluidine blue (ZnCl2) stains the acidic components of these tissues, such as sulfated or carboxylated mucopolysaccharides. It is frequently used in histology, cytology, and pathology applications to aid in the diagnosis of various diseases and conditions. The dye is usually applied to tissue sections prior to microscopic examination and can be differentiated using an acidic alcohol solution. Toluidine blue (ZnCl2) is a relatively simple and inexpensive stain with good reproducibility, making it a popular choice for many laboratories.

HY-W005828

9-(Boc-amino)nonanoic acid	PROTAC Linkers	Cancer
9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. 9-(Boc-amino)nonanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-42222

N1,N5-Bis-boc-spermidine	Biochemical Assay Reagents	Others
N1,N5-Bis-Boc-spermidine is a linker containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W053842

tert-Butyl 3-iodopropylcarbamate	Biochemical Assay Reagents	Others
tert-Butyl 3-iodopropylcarbamate is a compound with a t-butyl and a terminal iodine. The iodine (I) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-44370

Boc-Gly-Gly-Gly-Gly-Gly	ADC Linker	Cancer
(tert-Butoxycarbonyl)glycyl-glycyl-glycyl-glycyl-glycine is an ADC linker with a Boc group on the N terminus, and it is used for the development of antibody-drug conjugates (ADCs). The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-P11189

Astacidin 1	Bacterial	Infection
Astacidin 1 is an antibacterial peptide. Astacidin 1 can be produced by a proteolytic cleavage from hemocyanin under acidic conditions. Astacidin 1 has broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria .

HY-130628

PAK4-IN-1	PAK	Cancer
PAK4-IN-1 (Compound 19) is a potent, selective, orally active PAK4 inhibitor with robust anti-tumor efficacy in vivo. PAK4-IN-1 is stable under both acidic and neutral conditions .

HY-D1463

Nile Blue Methacrylamide	Fluorescent Dye	Others
Nile Blue Methacrylamide is a pH-responsive probe. Nile Blue Methacrylamide exhibits pH-sensitive absorption and fluorescence emission in the physiological pH range, with spectral shifts occurring between acidic and near-physiological pH conditions . (Ex/Em = 590/670-700 nm)

HY-W259542

O-Proparagyl-N-Boc-ethanolamine	Biochemical Assay Reagents	Others
O-Proparagyl-N-Boc-ethanolamine is crosslinker consisting of a propargyl group and a t-Boc protected amine group. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The t-Boc protected amine can be deprotected under mild acidic conditions.

HY-157006A

TCO-PEG3-NH2	Biochemical Assay Reagents	Others
TCO-PEG3-NH2 is a click chemistry reagent that contains a TCO group and undergoes the inverse electron-demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules .

HY-W101722

tert-Butyl (9-aminononyl)carbamate	PROTAC Linkers	Cancer
tert-Butyl (9-aminononyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W190921

t-Butyl 3-(hydroxypropoxyl)-propanoate	Biochemical Assay Reagents	Others
t-Butyl 3-(hydroxypropoxyl)-propanoate contains reactive hydroxyl and t-butyl protected carboxyl moieties. The hydroxyl group can react to further derivatize the compound. The t-butyl carbonyl group can be deprotected under acidic conditions.

HY-D0305

Tropaeolin O	Fluorescent Dye	Others
Tropaeolin O is an acidic monoazo dye that undergoes a coupling reaction under pH=10.5 conditions to form a blue disazo dye. Tropaeolin O can be used for the determination of palladium(II), osmium(IV), albumin, and casein .

HY-15931

TMB-PS TMBZ-PS	Fluorescent Dye	Others
TMB-PS(102062-36-2) is N-(3-sulfopropyl)-3,3',5,5'-tetramenthylbenzidine sodium salt; White - pale yellow crystalline powder, soluble in water, can be used under neutral, acidic and alkaline conditions.

HY-16261C

Aldoxorubicin hydrochloride INNO-206 hydrochloride; DOXO-EMCH hydrochloride	Topoisomerase ADC Payload	Cancer
Aldoxorubicin (INNO-206) hydrochloride is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin hydrochloride (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models.

HY-400345

tBu-C18 diacid-D-Glu-OtBu	Biochemical Assay Reagents	Others
t-butyl-C18-D-Glu-OtBu is comprised of an octadecanedioic acid with a terminal t-butyl ester and a glutamic acid, which is also protected by a terminal t-butyl ester. The t-butyl groups can be deprotected under acidic conditions. Glutamic acid is an α-amino acid that is used in the biosynthesis of proteins.

HY-Y1132

2-Amino-6-chlorobenzoic acid 6-Chloroanthranilic acid	Biochemical Assay Reagents	Others
2-Amino-6-chlorobenzoic acid is an autocoupling diazotization reagent used for spectrophotometric detection of nitrite ions in water. 2-Amino-6-chlorobenzoic acid exhibits good tolerance to various anions under acidic conditions. 2-Amino-6-chlorobenzoic acid is commonly used as a reagent in organic synthesis and analytical chemistry .

HY-77957

1-O-Methyl-2-deoxy-D-ribose	Biochemical Assay Reagents	Others
1-O-Methyl-2-deoxy-D-ribose is a ribose derivative that can be more conveniently obtained through a one-step reaction by introducing a methoxy protective group at the anomeric carbon position under acidic conditions. This facilitates the acquisition of 2-deoxy-D-ribose. 1-O-Methyl-2-deoxy-D-ribose can be utilized in research on the synthesis of chemical materials .

HY-W089232

Boc-10-Aminodecanoic acid	PROTAC Linkers	Cancer
Boc-10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W101723

Boc-12-Ado-OH	PROTAC Linkers	Cancer
Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-42213

N1,N4-Bis-Boc-spermidine	Biochemical Assay Reagents	Others
N1,N4-Bis-Boc-spermidine is a linker containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W190930

t-Butyl 1,5-di(ethoxycarbonyl)pentan-3-ylcarbamate	Biochemical Assay Reagents	Others
t-Butyl 1,5-di(ethoxycarbonyl)pentan-3-ylcarbamate is a branched molecule with an n-Boc group and two ethyl ester moieties. The Boc-protected amine can be deprotected under acidic conditions.

HY-W092176

1,9-Bis-boc-1,5,9-triazanonane	Biochemical Assay Reagents	Others
1,9-Bis-Boc-1,5,9-triazanonane is a linker containing two Boc-protected amino groups. The Boc groups can be deprotected under mild acidic conditions to form the free amines.

HY-169038

11(Z),14(Z)-Eicosadienoic acid ethanolamide	Cannabinoid Receptor Drug Derivative	Neurological Disease
11(Z),14(Z)-Eicosadienoic acid ethanolamide (Compound 3) is an ethanolamide-conjugated form of 11(Z),14(Z)-Eicosadienoic acid (HY-149589). 11(Z),14(Z)-Eicosadienoic acid ethanolamide inhibits the inactivating transport of an endogenous cannabinoid substance with an IC₅₀ value of 10.6 μM. 11(Z),14(Z)-Eicosadienoic acid ethanolamide can be used for research of neuropsychiatric conditions .

HY-W174661

tert-Butyl 6-hydroxyhexanoate	Biochemical Assay Reagents	Others
tert-Butyl 6-hydroxyhexanoate is a linker with a hydroxyl group and a t-butyl ester. The hydroxyl group allows for further derivatization or replacement with many other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

HY-W131541

N-Boc-undecane-1,11-diamine	PROTAC Linkers	Cancer
tert-Butyl (11-aminoundecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. tert-Butyl (11-aminoundecyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W800828

Iodoacetamido-PEG3-NHS ester	Biochemical Assay Reagents	Others
Iodoacetamido-PEG3-NHS ester is a PEG reagent containing an Iodoacetamide group and a Boc-protected amino group. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W190905

N4,N9-di-Boc-spermine	Biochemical Assay Reagents	Others
N4, N9-di-Boc-spermine is a spermine linker containing two a Boc-protected amino groups and two amine groups. The Boc groups can be deprotected under mild acidic conditions to form the free amine. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.

HY-W591964

t-Boc-aminooxy-pentane-azide	Biochemical Assay Reagents	Others
t-Boc-Aminooxy-pentane-azide is a linker containing an azide group and Boc-protected amino group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W800658

DBCO-PEG6-NH-Boc	Biochemical Assay Reagents	Others
DBCO-PEG6-NH-Boc is a click chemistry reagent with a DBCO group and a Boc-protected amine. The DBCO can undergo copper-free Click Chemistry reactions with azides. The Boc protecting group can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound.

Cat. No.	Product Name

HY-L123

Human Metabolite Library

6,717 compounds

Human metabolism is an integral part of cellular function that reflects individual differences in health, disease, diet, and lifestyle. Many health conditions such as obesity, diabetes, hypertension, heart disease, and cancer are associated with abnormal metabolic states. In the pathological state of the human body, metabolic pathways are significantly altered, resulting in aberrant levels of intermediates or end-products that can be viewed as potential diagnostic biomarkers or even therapeutic targets. Therefore, detection, identification and quantification of human metabolites are very important for drug metabolism research in drug development.

MCE offers a unique collection of 6,717 human metabolites, including endogenous metabolites and exogenous metabolites, covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins,. MCE Human Metabolites Library is a helpful tool for studying the relationship between diseases and metabolism.

HY-L192

Dietary Supplement Library

71 compounds

Dietary supplement, also known as nutritional supplement or food supplement, include dietary components such as vitamins, minerals, and amino acids. The unique value of dietary supplement is particularly significant in the post-pandemic era. Compared to traditional medication, dietary supplement is often more readily accepted by the public due to their higher safety profile and the natural origin. By orally supplementing essential nutrients and bioactive substances, dietary supplement can help to enhance the body's health level and reduce the risk of diseases. For certain chronic conditions, proper dietary supplement can also serve as a powerful adjunct to conventional medical treatment, enhancing the effectiveness of medication.

MCE has included 71 dietary supplements, whose ingredients are all derived from the official lists published by authoritative organizations such as the FDA, EFSA, NMPA, etc. These compounds can be utilized in the development of health food products and for the mechanistic research of certain chronic diseases.

Cat. No.	Product Name	Type

HY-D0715

Fluorescamine 1 Publications Verification Ro 20-7234	Fluorescent Dyes
Fluorescamine is a spirocyclic compound that is non-fluorescent. Fluorescamine reacts rapidly with primary amine groups in proteins under alkaline conditions to generate products with strong fluorescence (Ex/Em: 390/475 nm). Fluorescamine can be used to detect amine-containing compounds, including amino acids, peptides, and proteins .

HY-D1094

Carboxy-SNARF 1 (5/6-mixture) 1 Publications Verification SNARF 1	Fluorescent Dyes
Carboxy-SNARF 1 (5/6-mixture) (SNARF 1) is a fluorescent probe that is sensitive to pH (Ex: 488 nm). Carboxy-SNARF 1 (5/6-mixture) can be used for measurement pH. Carboxy-SNARF 1 (5/6-mixture) exhibits a significant emission shift from yellow-orange (Em: 580 nm) to deep red fluorescence (Em: 640 nm) under acidic and basic conditions (pH=7-8), respectively .

HY-W088068

Wright's stain

Fluorescent Dyes

Wright's stain is a composite cell stain that mainly binds to intracellular nucleic acids, proteins and other components through thiazine dyes (such as methylene blue) and eosin. Wright's stain is pH-dependent (optimal pH 6.4-6.7) and achieves cell morphology resolution by differentially staining the cytoplasm and nucleus. Under alkaline conditions, thiazine dyes bind to nucleic acids to form purple, and acidic eosin binds to cytoplasmic proteins to form red, which can form contrasting cell morphological features. Wright's stain can clearly display the fine structures of blood cells and bone marrow cells (such as nuclear chromatin and granules) and quickly evaluate cell morphological abnormalities .

HY-W923198

Fluorescein O-methacrylate

Methacryloyloxy fluorescein

Fluorescent Dyes

Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-responsive fluorescent monomeric dye. Fluorescein O-methacrylate exhibits pH-responsive fluorescence properties: its fluorescence is activated under alkaline conditions and quenched under neutral or acidic conditions; reversible switching of fluorescence is achievable by adjusting the pH of the solution. Fluorescein O-methacrylate can be used as a monomer for the synthesis of amphiphilic fluorescein polymers. These polymers can self-assemble into stable polymer nanoparticles with enhanced aqueous-phase fluorescence, and also enable the conjugation of nanoparticles with amine-containing biomolecules to support sensitive optical detection of biomarkers (Ex/Em = 490/520 nm) .

HY-W998680

Fluorescein-maleimide

5-FITC-Maleimide

Fluorescent Dyes

Fluorescein-maleimide (5-FITC-Maleimide) is a thiol-reactive fluorescent derivatization reagent and non-specific protein labeling reagent. Fluorescein-maleimide covalently binds to protein thiol groups for protein labeling. Fluorescein-maleimide covalently binds to protein amino and imidazole groups under neutral pH conditions. Fluorescein-maleimide is used for fluorescent labeling of proteins, nucleic acids or other molecules containing one or more thiol groups (Ex/Em = 494/519 nm) .

HY-D0219

Thymol blue

Thymolsulphonephthalein

Fluorescent Dyes

Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. Thymol blue is red (HI ^- form) under acidic conditions and blue (I ^2- form) under alkaline conditions. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue selectively responds to pH changes, changing from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6. Thymol blue can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field[1][2].

HY-W250143

Toluidine blue (ZnCl2)

Fluorescent Dyes

Toluidine blue (ZnCl2) is a basic thiazine dye commonly used as a biological stain for microscopy. It has a deep bluish-purple color and is commonly used to stain nucleic acids such as DNA and RNA, as well as to stain mast cells, cartilage, and other connective tissues. Toluidine blue (ZnCl2) stains the acidic components of these tissues, such as sulfated or carboxylated mucopolysaccharides. It is frequently used in histology, cytology, and pathology applications to aid in the diagnosis of various diseases and conditions. The dye is usually applied to tissue sections prior to microscopic examination and can be differentiated using an acidic alcohol solution. Toluidine blue (ZnCl2) is a relatively simple and inexpensive stain with good reproducibility, making it a popular choice for many laboratories.

HY-D1463

Nile Blue Methacrylamide	Fluorescent Dyes
Nile Blue Methacrylamide is a pH-responsive probe. Nile Blue Methacrylamide exhibits pH-sensitive absorption and fluorescence emission in the physiological pH range, with spectral shifts occurring between acidic and near-physiological pH conditions . (Ex/Em = 590/670-700 nm)

HY-15931

TMB-PS TMBZ-PS	Fluorescent Dyes
TMB-PS(102062-36-2) is N-(3-sulfopropyl)-3,3',5,5'-tetramenthylbenzidine sodium salt; White - pale yellow crystalline powder, soluble in water, can be used under neutral, acidic and alkaline conditions.

HY-D0715R

Fluorescamine (Standard)

Ro 20-7234 (Standard)

Fluorescent Dyes

Fluorescamine (Standard) is the analytical standard of Fluorescamine (HY-D0715). This product is intended for research and analytical applications. Fluorescamine is a spirocyclic compound that is non-fluorescent. Fluorescamine reacts rapidly with primary amine groups in proteins under alkaline conditions to generate products with strong fluorescence (Ex/Em : 390/475 nm). Fluorescamine can be used to detect amine-containing compounds, including amino acids, peptides, and proteins .

HY-172717

TAMRA-PEG4-t-butyl ester	Fluorescent Dyes
TAMRA-PEG4-t-butyl ester is a TAMRA red-fluorescent dye linker, with excitation/emission maximum 553/575 nm, containing a t-butyl protected carboxyl group which can be deprotected under acidic conditions.

HY-D2998

ONOO-LysopH

Fluorescent Dyes

ONOO-LysopH is a new Rhodamine-based near-infrared fluorescent probe. ONOO-LysopH is acid-sensitive, exhibiting rapid near-infrared fluorescence enhancement around 686 nm under acidic pH conditions. ONOO-LysopH also displays a rapid NIR turn-on fluorescence around 678 nm for ONOO− at physiological pH. ONOO-LysopH can target lysosomes to track lysosomal pH changes and image endogenous/exogenous ONOO− in live cells. ONOO-LysopH is applicable for cell imaging ONOO− and tracking lysosomal pH changes .

Cat. No.	Product Name	Type

HY-W250308

ε-Poly-L-lysine (MW 3800-4200)

Epsilon-polylysine (MW 3800-4200); ε-Polylysine (MW 3800-4200); ε-PL (MW 3800-4200)

Biochemical Assay Reagents

Epsilon-polylysine is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine is also used as a liposome stabilizer .

HY-NP165

Advanced glycation end products

AGEs

Biochemical Assay Reagents

Advanced glycation end products (AGEs) are a series of stable compounds generated through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. Advanced glycation end products are often used as targets to evaluate the inhibitory effects of anti-glycation compounds. Advanced glycation end products can be applied to research on diabetes, cardiovascular and cerebrovascular diseases, inflammation, aging, and other conditions .

HY-40228

(R)-(+)-tert-Butylsulfinamide

(R)-2-Methylpropane-2-sulfinamide

Biochemical Assay Reagents

(R)-(+)-tert-Butylsulfinamide ((R)-2-Methylpropane-2-sulfinamide) is a chiral reagent commonly used in the asymmetric synthesis of compounds such as amines, amino acids, and amino alcohols. (R)-(+)-tert-Butylsulfinamide achieves stereoselective reactions by condensing with carbonyl groups to form sulfinyl imine intermediates, and after the reaction, this group can be removed under acidic conditions to obtain the target product .

HY-W019927

Ammonium iron(III) sulfate dodecahydrate, 99% Ammonium ferric sulfate dodecahydrate, 99%	Biochemical Assay Reagents
Ammonium iron(III) sulfate dodecahydrate, 99% is an analytical reagent-grade iron(III) salt and source material for iron(III) reagent or standard solutions in volumetric analysis .

HY-I0259

8-Amino-2-naphthol

Biochemical Assay Reagents

8-Amino-2-naphthol is a photoactive charge transfer compounds, which can be used as fluorescent probe. 8-Amino-2-naphthol undergoes excited-state proton transfer (ESPT) to form a zwitterion under acidic conditions, where the photoacidity of its hydroxyl group is regulated by the protonation state of the amino group, enabling pH to act as an on/off switch for photoacidity. 8-Amino-2-naphthol is also utilized as chiral organocatalyst .

HY-W111692

Sodium polyphosphate, crystal,+200 mesh, 96%

Biochemical Assay Reagents

Sodium polyphosphate, crystal,+200 mesh, 96% is an inorganic polyphosphate that also serves as a stabilizer, dispersant, chelating agent, and coacervate-forming agent. Sodium polyphosphate provides electrostatic stabilization for mineral and material suspensions, but its dispersing efficacy decreases under acidic pH, high temperature, high calcium concentration, or a combination of these conditions. Sodium polyphosphate can chelate alkaline earth metals, reduce solution pH, and alter the rate of pH decline at a divalent cation/phosphorus molar ratio of 0.18. Sodium polyphosphate forms coacervates with smaller divalent cations and precipitates with larger divalent cations, where the functional requirements of cations depend on polyphosphate concentration, average degree of polymerization, and cation type .

HY-138540

1-Dodecylimidazole 3 Publications Verification N-Dodecylimidazole	Biochemical Assay Reagents
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .

HY-W250146

Locust bean gum, from Ceratonia siliqua seeds

Locust bean gum, Polysaccharide>75%, 5000-6500 mPa·S

Biochemical Assay Reagents

Locust bean gum is a natural polysaccharide derived from the seeds of the carob tree. It is commonly used as a thickening, stabilizing and gelling agent in a variety of foods, including dairy, baked goods and meat products. Locust bean gum has several properties suitable for these applications, including high water retention capacity, ability to form stable gels at low temperatures, and resistance to acidic conditions. Additionally, it can be used as a dietary fiber supplement due to its potential health benefits, including improving digestion and lowering cholesterol levels.

HY-Y1361

Diethyl D-(-)-tartrate

D-(-)-Tartaric acid diethyl ester

Biochemical Assay Reagents

Diethyl D-(-)-tartrate (D-(-)-Tartaric acid diethyl ester) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Diethyl D(-)-tartrate can also react with fatty carbonyl compounds to form bis(sodium carboxylate) types of surfactants, which have good water solubility, strong ability to lower surface tension, and can be easily decomposed under acidic conditions .

HY-D0305

Tropaeolin O	Biochemical Assay Reagents
Tropaeolin O is an acidic monoazo dye that undergoes a coupling reaction under pH=10.5 conditions to form a blue disazo dye. Tropaeolin O can be used for the determination of palladium(II), osmium(IV), albumin, and casein .

HY-Y1132

2-Amino-6-chlorobenzoic acid 6-Chloroanthranilic acid	Biochemical Assay Reagents
2-Amino-6-chlorobenzoic acid is an autocoupling diazotization reagent used for spectrophotometric detection of nitrite ions in water. 2-Amino-6-chlorobenzoic acid exhibits good tolerance to various anions under acidic conditions. 2-Amino-6-chlorobenzoic acid is commonly used as a reagent in organic synthesis and analytical chemistry .

HY-77957

1-O-Methyl-2-deoxy-D-ribose	Biochemical Assay Reagents
1-O-Methyl-2-deoxy-D-ribose is a ribose derivative that can be more conveniently obtained through a one-step reaction by introducing a methoxy protective group at the anomeric carbon position under acidic conditions. This facilitates the acquisition of 2-deoxy-D-ribose. 1-O-Methyl-2-deoxy-D-ribose can be utilized in research on the synthesis of chemical materials .

HY-159063

Soy Polysaccharides

Biochemical Assay Reagents

Soy Polysaccharides are biochemical reagents that can be added to beverages, sauces, and dairy products as thickeners, emulsifiers, and dietary fiber ingredients. Soy Polysaccharides are non-toxic, hydrophilic, and biodegradable, allowing for widespread application in various food sectors. Additionally, Soy Polysaccharides serve as effective stabilizers in oil/water emulsions. Even under acidic conditions, Soy Polysaccharides can stabilize β-conglycinin-based emulsions to prevent flocculation .

HY-138540R

1-Dodecylimidazole (Standard)

N-Dodecylimidazole (Standard)

Biochemical Assay Reagents

1-Dodecylimidazole (Standard) is the analytical standard of 1-Dodecylimidazole. This product is intended for research and analytical applications. 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .

Cat. No.	Product Name	Target	Research Area

HY-P1856

Proinsulin C-peptide (human) 1 Publications Verification	Insulin Receptor PDGFR MAPKAPK2 (MK2)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Proinsulin C-peptide (human) is a peptide consisting of 31 amino acids that links the A and B chains of proinsulin to ensure its correct folding. Proinsulin C-peptide (human) inhibits the high glucose-induced increase in PDGF-β receptor protein expression and the phosphorylation of p42/p44 MAP kinase. Proinsulin C-peptide (human) increases the deformability of erythrocytes derived from type 1 diabetes, inhibits insulin-induced neointimal thickening, and suppresses the proliferation of rat aortic smooth muscle cells cultured under high-glucose conditions .

HY-P1047

β-Sheet Breaker Peptide iAβ5 [Pro18, Asp21] β-Amyloid (17-21)	Amyloid-β	Neurological Disease
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.

HY-P5174

MitTx	Sodium Channel	Neurological Disease
MitTx is a complex formed by MitTx-α and MitTx-β. MitTx is an ASIC1 channel activator with EC₅₀ values of 9.4 and 23 nM for ASIC1a and ASIC1b isoforms, respectively. MitTx is highly selective for ASIC1 isoforms at neutral pH. Under acidic conditions, MitTx greatly enhances proton-evoked ASIC2a channel activation .

HY-34611

Boc-L-2,4-Diaminobutyric acid N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH	Drug Intermediate ASCT	Neurological Disease Cancer
Boc-L-2,4-Diaminobutyric acid (N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH) is a versatile synthetic starting material with a cleavable protecting group. Boc-L-2,4-Diaminobutyric acid not only reduces the backbone cleavage rate by protecting the side-chain γ-amino group, but also triggers intramolecular cyclization of self-immolative linkers under acidic cleavage conditions, thus constructing stimuli-responsive materials. Boc-L-2,4-Diaminobutyric acid is also an important building block for bioactive molecules. It can be used in the synthesis of ASCT2 (SLC1A5) inhibitors and carboxynorspermine, and can also serve as an internal standard to support the quantitative detection of specific intracellular amino acids by UPLC-QQQ-MS .

HY-P11189

Astacidin 1	Bacterial	Infection
Astacidin 1 is an antibacterial peptide. Astacidin 1 can be produced by a proteolytic cleavage from hemocyanin under acidic conditions. Astacidin 1 has broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria .

HY-P5172

MitTx-alpha	Sodium Channel	Neurological Disease
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels .

HY-P1128

Galanin (swine)	Neuropeptide Y Receptor	Metabolic Disease
Galanin (swine), a neuropeptide, consists of 29 amino acids and contains a C-terminal amidated glycine. Galanin (swine) inhibits basal and stimulated insulin secretion both in vivo and in vitro under a variety of experimental conditions. Galanin (swine) is a galanin receptor agonist with pK_is of 9.63, 9.49, 9.02, 8.98, 8.01 and 8.14 at human GAL1, rat GAL1, human GAL2, rat GAL2, human GAL3 and rat GAL3 respectively .

HY-P1128A

Galanin (swine) TFA	Neuropeptide Y Receptor	Metabolic Disease
Galanin (swine) TFA, a neuropeptide, consists of 29 amino acids and contains a C-terminal amidated glycine. Galanin (swine) inhibits basal and stimulated insulin secretion both in vivo and in vitro under a variety of experimental conditions. Galanin (swine) TFA is a galanin receptor agonist with pK_is of 9.63, 9.49, 9.02, 8.98, 8.01 and 8.14 at human GAL1, rat GAL1, human GAL2, rat GAL2, human GAL3 and rat GAL3 respectively .

HY-P10794

LH2 peptide	Peptides	Cancer
LH2 peptide is a pH-responsive cell-penetrating peptide dimer with the amino acid sequence LHHLCHLLHHLCHLAG. It can increase its uptake in tumor cells under weakly acidic conditions (such as the tumor microenvironment) through the protonation of histidine residues (pK_a approximately 6). When conjugated with the anticancer drug Paclitaxel (HY-B0015), the PTX-LH2 conjugate showed superior tumor suppression effects compared to paclitaxel alone in a subcutaneous breast tumor model. The LH2 peptide holds potential as a drug delivery vehicle in cancer research .

HY-P4599B

H-His-His-OH acetate	Biochemical Assay Reagents	Others
H-His-His-OH acetate is an oligopeptide. H-His-His-OH acetate can chelate with Ruthenium (II). H-His-His-OH inhibits the hydrolysis of metal ions at pH 7.4 .

Cat. No.	Product Name		Classification

HY-W800658

DBCO-PEG6-NH-Boc		DBCO
DBCO-PEG6-NH-Boc is a click chemistry reagent with a DBCO group and a Boc-protected amine. The DBCO can undergo copper-free Click Chemistry reactions with azides. The Boc protecting group can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound.

HY-W457953

tert-Butyl N-(4-azidobutyl)carbamate		Azide
tert-Butyl N-(4-azidobutyl)carbamate is N-Boc protected crosslinker. tert-Butyl N-(4-azidobutyl)carbamate can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

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