Advanced glycation end products
Based on 1 Customer Validation
Advanced glycation end products (AGEs) are a series of stable compounds generated through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. Advanced glycation end products are often used as targets to evaluate the inhibitory effects of anti-glycation compounds. Advanced glycation end products can be applied to research on diabetes, cardiovascular and cerebrovascular diseases, inflammation, aging, and other conditions.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Advanced glycation end products enhance tumorigenicity, invasion, and migration of triple-negative breast cancer cells by upregulating MMP-9 expression via ERK and NF-κB pathway activation[1].
Advanced glycation end products induce dysfunction and damage in human aortic endothelial cells via activation of MAPK, NF-κB, and AP-1 signaling[2].
Advanced glycation end products alter gut microbiota composition, induce intestinal epithelial cell damage and gut barrier dysfunction, and drive systemic inflammation and multiorgan injury[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Advanced glycation end products induces cardiac fibrosis in mice by increasing collagen deposits, inducing diastolic dysfunction, and promoting fibroblast-to-myofibroblast differentiation[2].
Advanced glycation end products promote alcohol-induced brain inflammation, apoptosis, and neuronal damage via RAGE and MAPK pathway activation[3].
Advanced glycation end products (high-AGEs diet) delays wound healing in mice by promoting persistent inflammatory cell infiltration and fibrous scar formation[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Appearance Liquid
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Color Light yellow to yellow
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SMILES
[Advanced glycation end products]
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Synonyms
AGEs
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Twarda-Clapa A, et al. Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs. Cells. 2022 Apr 12;11(8):1312. [Content Brief]
[2]. Kosmopoulos M, et al. Impact of advanced glycation end products (AGEs) signaling in coronary artery disease. Biochim Biophys Acta Mol Basis Dis. 2019;1865(3):611-619. [Content Brief]
[3]. Rungratanawanich W, et al. Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury. Exp Mol Med. 2021;53(2):168-188. [Content Brief]
[4]. Singh R, et al. Advanced glycation end-products: a review. Diabetologia. 2001;44(2):129-146. [Content Brief]
[5]. Haque E, et al. Advanced glycation end products (AGEs), protein aggregation and their cross talk: new insight in tumorigenesis. Glycobiology. 2019 Dec 12;30(1):49-57. [Content Brief]
[6]. Ilea A, et al. Advanced glycation end products (AGEs) in oral pathology. Arch Oral Biol. 2018;93:22-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Advanced glycation end products Related Classifications
HY-NP165 Related Classifications
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