Boc-L-2,4-Diaminobutyric acid (Synonyms: N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH)

Name: Boc-L-2,4-Diaminobutyric acid
Brand: MedChemExpress
SKU: HY-34611
Rating: 4.5 (0 reviews)

Cat. No.: HY-34611 Pureza: 98.0%: Ficha de datos
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Instrucciones de manejo
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Boc-L-2,4-Diaminobutyric acid (N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH) is a versatile synthetic starting material with a cleavable protecting group. Boc-L-2,4-Diaminobutyric acid not only reduces the backbone cleavage rate by protecting the side-chain γ-amino group, but also triggers intramolecular cyclization of self-immolative linkers under acidic cleavage conditions, thus constructing stimuli-responsive materials. Boc-L-2,4-Diaminobutyric acid is also an important building block for bioactive molecules. It can be used in the synthesis of ASCT2 (SLC1A5) inhibitors and carboxynorspermine, and can also serve as an internal standard to support the quantitative detection of specific intracellular amino acids by UPLC-QQQ-MS.

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Síntesis de péptidos personalizados

Boc-L-2,4-Diaminobutyric acid Estructura química

No. CAS : 25691-37-6

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	En stock	Estimated Time of Arrival: December 31
Solid
5 g	En stock	Estimated Time of Arrival: December 31
10 g	En stock	Estimated Time of Arrival: December 31
50 g	Obtener un presupuesto

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Based on 1 Customer Validation

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•Related Screening Libraries:

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•Related Proteins:

Ver todos los productos específicos de isoformas ASCT:

Ver todas las isoformas

ASCT2

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Descripciòn

In Vitro

Boc-L-2,4-diaminobutyric acid (0.88 mmol; 2 h) is a key synthetic precursor of AA201, a probe targeting ASCT2, and is obtained via amide condensation with Azidoacetic Acid (HY-151719)^[4].
Boc-L-2,4-diaminobutyric acid serves as an internal standard for UPLC-QQQ-MS, which is used to normalize the levels of AA201 in HCT116, PC3 and HepG2 cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

218.25

Fòrmula

C₉H₁₈N₂O₄

No. CAS

25691-37-6

Appearance

Solid

Color

Off-white to light yellow

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

H₂O : 100 mg/mL (458.19 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5819 mL	22.9095 mL	45.8190 mL
5 mM	0.9164 mL	4.5819 mL	9.1638 mL
10 mM	0.4582 mL	2.2910 mL	4.5819 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 98.0%

Select Batch:

Ficha de datos (272 KB) SDS (476 KB)

COA (246 KB) HNMR (117 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Mejia J S, et al. Triggered degradation of poly (ester amide) s via cyclization of pendant functional groups of amino acid monomers[J]. Polymer Chemistry, 2013, 4(6): 1969-1982.

[2]. Schulte ML, et al. 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport. Bioorg Med Chem Lett. 2016;26(3):1044-1047. [Content Brief]

[3]. Lee J, et al. An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. J Biol Chem. 2009;284(15):9899-9907. [Content Brief]

[4]. Zhou BJ, et al. Real-Time Tracking of ASCT2-Mediated Glutamine Uptake in Living Tumors With a Bioorthogonal Bioluminescent Probe. Adv Sci (Weinh). 2025;12(40):e07057. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.5819 mL	22.9095 mL	45.8190 mL	114.5475 mL
	5 mM	0.9164 mL	4.5819 mL	9.1638 mL	22.9095 mL
	10 mM	0.4582 mL	2.2910 mL	4.5819 mL	11.4548 mL
	15 mM	0.3055 mL	1.5273 mL	3.0546 mL	7.6365 mL
	20 mM	0.2291 mL	1.1455 mL	2.2910 mL	5.7274 mL
	25 mM	0.1833 mL	0.9164 mL	1.8328 mL	4.5819 mL
	30 mM	0.1527 mL	0.7637 mL	1.5273 mL	3.8183 mL
	40 mM	0.1145 mL	0.5727 mL	1.1455 mL	2.8637 mL
	50 mM	0.0916 mL	0.4582 mL	0.9164 mL	2.2910 mL
	60 mM	0.0764 mL	0.3818 mL	0.7637 mL	1.9091 mL
	80 mM	0.0573 mL	0.2864 mL	0.5727 mL	1.4318 mL
	100 mM	0.0458 mL	0.2291 mL	0.4582 mL	1.1455 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Boc-L-2,4-Diaminobutyric acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Boc-L-2,4-Diaminobutyric acid (Synonyms: N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH)

Revisión del cliente

Boc-L-2,4-Diaminobutyric acid Related Antibodies

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas ASCT:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Boc-L-2,4-Diaminobutyric acid Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

Boc-L-2,4-Diaminobutyric acid Related Classifications

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SAFETY DATA SHEET (SDS)

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