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Cat. No.: HY-181436

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CAY10563

CAY10563 is a pH-regulated NO donor. Under acidic conditions, CAY10563 releases NO via an acid-catalyzed ring-opening mechanism, generating sulfur-centered free radicals. CAY10563 induces pH-dependent vasodilation. CAY10563 can be used in studies related to cardiovascular and cerebrovascular diseases.

For research use only. We do not sell to patients.

CAS No.: 940952-42-1
Formula: C₉H₄F₃NO₂S
Molecular Weight:247.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CAY10563 Chemical Structure

CAS No.: 940952-42-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All NO Synthase Isoforms :

In Vitro

CAY10563 (Compound 3a) (20 mM) releases NO in an acid-dependent manner at pH 5.0, with an overall NO yield of approximately 27%. No NO release is detected under neutral pH conditions, and it induces the formation of sulfur-centered radicals^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 940952-42-1
Molecular Weight 247.19
Formula C₉H₄F₃NO₂S
SMILES

[O-]C1=C(C2=CC=C(C=C2)C(F)(F)F)[S+]=NO1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lu D, et al. 4-Aryl-1,3,2-oxathiazolylium-5-olates as pH-controlled NO-donors: the next generation of S-nitrosothiols. J Am Chem Soc. 2007;129(17):5503-5514. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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