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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
54 Results for "
amyloid β-peptides
" in MedChemExpress (MCE) Product Catalog:
Products (54)
54 Results for "amyloid β-peptides" in MCE Product Catalog:
51
51 Publications Verification
Cat. No.: HY-P0128
CAS No.: 131602-53-4
Synonyms: amyloid beta-peptide (25-35); Aβ25-35; β-amyloid peptide (25-35)
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51
51 Publications Verification
Cat. No.: HY-P0128A
CAS No.: 131602-53-4
Synonyms: amyloid beta-peptide (25-35), HFIP-treated; Aβ25-35, HFIP-treated; β-amyloid peptide (25-35), HFIP-treated
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27
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β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
27
27 Cited Publications
Cat. No.: HY-P1363A
CAS No.: 107761-42-2
Synonyms: amyloid β-peptide (1-42) (human)
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β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
4
Category:
Monophenols Simple Phenylpropanols Phenols Dicerothamnus rhinocerotis Phenylpropanoids Plants Umbelliferae
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2
1
1 Cited Publications
Cat. No.: HY-P1362
CAS No.: 317366-82-8
Synonyms: amyloid β Peptide (42-1)(human)
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1
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Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively .
Cat. No.: HY-P99317
CAS No.: 955085-14-0
Synonyms: LY-2062430
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Solanezumab (LY-2062430) is a humanized monoclonal IgG1 antibody directed against the mid-domain of the amyloid-β (Aβ) peptide. Solanezumab binds to the mid-domain of monomeric amyloid-beta to slow brain amyloid accumulation. Solanezumab can be used for the research of Alzheimer’s disease .
Cat. No.: HY-17631A
CAS No.: 519187-97-4
Synonyms: T-817 maleate; T-817MA
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Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
Cat. No.: HY-N4285
CAS No.: 29550-13-8
Synonyms: 5,6-Dihydroxy-7-methoxyflavone
Cat. No.: HY-P1363F1
Synonyms: Biotin-amyloid β-peptide (1-42) (human) TFA
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Cat. No.: HY-P3688A
Synonyms: Aβ (1-38) TFA; Aβ38 TFA
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Cat. No.: HY-P4882A
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Cat. No.: HY-P1962
CAS No.: 350228-37-4
Synonyms: [Asn670, Sta671, Val672]-amyloid β Peptide (662-675)
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Cat. No.: HY-N8161
CAS No.: 25615-14-9
Synonyms: Kaempferol 3,7-diglucoside
Category:
Flavonols other families Flavonoids Phenols Polyphenols Plants
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Cat. No.: HY-P1362F
Synonyms: Cy5-amyloid β Peptide (42-1)(human) Tris
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Cat. No.: HY-P1387
CAS No.: 144409-98-3
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Cat. No.: HY-150049
CAS No.: 1353570-40-7
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γ-Secretase modulator 13 (compound 4) is a gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 163 nM. γ-Secretase modulator 13 can be used in the study of Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
