BChE-IN-31
BChE-IN-31 (Compound 14d) is a selective BChE inhibitor with an IC50 of 65 nM. BChE-IN-31 inhibits the self-induced aggregation of neurotoxic amyloid-β (Aβ) peptide.
For research use only. We do not sell to patients.
- Formula: C31H42N4O
- Molecular Weight:486.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BChE 65 nM (IC50) |
AChE 5.9 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| SH-SY5Y | IC50 |
60 μM
Compound: 14d
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Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 38579622] |
BChE-IN-31 (0-20 μM, 24 h) exhibits a protective effect against NMDA (HY-17551)-induced toxicity and H2O2-induced oxidation in SH-SY5Y cells at 5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y
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Concentration:0-20 μM
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Incubation Time:24 h
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Result:Improved the cell viability at 5 μM, inhibited cell viability dose-dependently at 5-20 μM.
Chemical Information
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Molecular Weight 486.69
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Formula C31H42N4O
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SMILES
O=C1NCCCC2=C1C3=CC=CC=C3N2CCCCCCCN4CCN(CCC5=CC=CC=C5)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BChE-IN-31 Related Classifications
HY-163441 Related Classifications
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