Astrophloxine
Based on 1 Customer Validation
Astrophloxine is a fluorescent imaging probe capable of targeting antiparallel dimers. Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples of Alzheimer's disease (AD) mice.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.34%
- CAS. Nr.: 14696-39-0
- Formel: C27H33IN2
- Molecular Weight:512.47
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
Antiparallel dimer[1]
In Vitro
Astrophloxine binds Aβ dimers with stronger fluorescence intensity (A.U.) than binding Aβ monomers[1].
Protocol for CSF analyses[1]:
1.Prepare 1 μL of CSF samples with 1 μL of 10X protease inhibitors and diluted the mixture with 8 μL of binding buffer. Binding buffer (0.1 M sodium phosphate, 0.15 M sodium chloride, 10 mM EDTA; pH 7.2).
2.Dilute Astrophloxine to 0.5 μM with binding buffer.
3.Add individual samples and dye to the wells of a 96-well half-area black microplate with a sample to dye ratio of 1:3.
Detect at λex=540 nm/λem=570 nm.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 14696-39-0
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Appearance Solid
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Molecular Weight 512.47
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Formel C27H33IN2
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Color Dark purple to black
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SMILES
CC1(C)C(/C=C/C=C2N(CC)C3=C(C=CC=C3)C\2(C)C)=[N+](CC)C4=C1C=CC=C4.[I-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (97.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9513 mL | 9.7567 mL | 19.5133 mL | 48.7833 mL |
| 5 mM | 0.3903 mL | 1.9513 mL | 3.9027 mL | 9.7567 mL | |
| 10 mM | 0.1951 mL | 0.9757 mL | 1.9513 mL | 4.8783 mL | |
| 15 mM | 0.1301 mL | 0.6504 mL | 1.3009 mL | 3.2522 mL | |
| 20 mM | 0.0976 mL | 0.4878 mL | 0.9757 mL | 2.4392 mL | |
| 25 mM | 0.0781 mL | 0.3903 mL | 0.7805 mL | 1.9513 mL | |
| 30 mM | 0.0650 mL | 0.3252 mL | 0.6504 mL | 1.6261 mL | |
| 40 mM | 0.0488 mL | 0.2439 mL | 0.4878 mL | 1.2196 mL | |
| 50 mM | 0.0390 mL | 0.1951 mL | 0.3903 mL | 0.9757 mL | |
| 60 mM | 0.0325 mL | 0.1626 mL | 0.3252 mL | 0.8131 mL | |
| 80 mM | 0.0244 mL | 0.1220 mL | 0.2439 mL | 0.6098 mL |
Astrophloxine Related Classifications
HY-112636 Related Classifications
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