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Astrophloxine 

Cat. No.: HY-112636
Handling Instructions

Astrophloxine is a fluorescent imaging probe capable of targeting antiparallel dimers. Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples of Alzheimer's disease (AD) mice.

For research use only. We do not sell to patients.

Astrophloxine Chemical Structure

Astrophloxine Chemical Structure

CAS No. : 14696-39-0

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Description

Astrophloxine is a fluorescent imaging probe capable of targeting antiparallel dimers. Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples of Alzheimer's disease (AD) mice[1].

IC50 & Target

Antiparallel dimer[1]

In Vitro

Astrophloxine binds Aβ dimers with stronger fluorescence intensity (A.U.) than binding Aβ monomers[1].
Protocol for CSF analyses[1]:
1.Prepare 1 μL of CSF samples with 1 μL of 10X protease inhibitors and diluted the mixture with 8 μL of binding buffer. Binding buffer (0.1 M sodium phosphate, 0.15 M sodium chloride, 10 mM EDTA; pH 7.2).
2.Dilute Astrophloxine to 0.5 μM with binding buffer.
3.Add individual samples and dye to the wells of a 96-well half-area black microplate with a sample to dye ratio of 1:3.
Detect at λex=540 nm/λem=570 nm.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Astrophloxine shows more fluorescence (A.U.) in APP/PS1 mice CSF rather in WT mice, and is able to indicate soluble Aβ oligomers in CSF and insoluble plaques in brain tissue[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

512.47

Formula

C27H33IN2

CAS No.
SMILES

CC1(C)C(/C=C/C=C2N(CC)C3=C(C=CC=C3)C\2(C)C)=[N+](CC)C4=C1C=CC=C4.[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Astrophloxine
Cat. No.:
HY-112636
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