1. Autophagy
  2. Autophagy
  3. SMER28

SMER28 

Cat. No.: HY-100200 Purity: 99.99%
Handling Instructions

SMER28 is a positive regulator of autophagy acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

For research use only. We do not sell to patients.

SMER28 Chemical Structure

SMER28 Chemical Structure

CAS No. : 307538-42-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
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25 mg USD 168 In-stock
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50 mg USD 324 In-stock
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100 mg USD 624 In-stock
Estimated Time of Arrival: December 31
200 mg USD 1020 In-stock
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500 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

SMER28 is a positive regulator of autophagy acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

In Vitro

SMER28 (5-200 μM; 24 hours) shows a dose dependent decline of cell viability[4].

Cell Viability Assay[4]

Cell Line: MMS1 cells
Concentration: 5, 25, 50, 75, 100, 150, 200 μM
Incubation Time: 24 hours
Result: Showed a dose dependent decline of cell viability.
In Vivo

SMER28 (15-65 mg/kg; i.h.; daily, two days before irradiation and during the three days of irradiation) significantly protects against post-irradiation weight loss and enhances survival of mice at 65 mg/kg[5].

Animal Model: 14 to 16 weeks male mice (Balb/c)[5]
Dosage: 15, 65 mg/kg
Administration: Subcutaneous injection; two days before irradiation and during the three days of irradiation (total 5 days)
Result: Significantly protected against post-irradiation weight loss and enhanced survival of mice at 65 mg/kg.
Molecular Weight

264.12

Formula

C₁₁H₁₀BrN₃

CAS No.

307538-42-7

SMILES

C=CCNC1=C2C=C(Br)C=CC2=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (121.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7862 mL 18.9308 mL 37.8616 mL
5 mM 0.7572 mL 3.7862 mL 7.5723 mL
10 mM 0.3786 mL 1.8931 mL 3.7862 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
SMER28
Cat. No.:
HY-100200
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