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Cat. No.: HY-100740A

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Lanabecestat hydrochloride

(Synonyms: AZD-3293 hydrochloride; LY3314814 hydrochloride)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Lanabecestat (AZD3293; LY3314814) hydrochloride is a potent BACE1 inhibitor that has been investigated for its potential as a modifying treatment for Alzheimer's disease. Lanabecestat (hydrochloride) demonstrated significant dose- and time-dependent reductions in concentrations of amyloid beta peptides in plasma, cerebrospinal fluid, and brain. Lanabecestat (hydrochloride) was also shown to produce reductions in Aβ neuritic plaque burden without demonstrating clinical benefits or slowing the progression of Alzheimer's disease pathophysiology.

For research use only. We do not sell to patients.

CAS No.: 1383986-31-9
Formula: C₂₆H₂₉ClN₄O
Molecular Weight:448.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Lanabecestat hydrochloride Chemical Structure

CAS No.: 1383986-31-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
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Bioz

Biological Activity

Description

All Beta-secretase Isoforms :

BACE1
BACE2

In Vivo

lanabecestat (5-25 mg/kg; p.o) hydrochloride displays significant dose- and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of Aβ₄₀, Aβ₄₂, and sAβPPβ in mice, guinea pigs, and dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1383986-31-9
Molecular Weight 448.99
Formula C₂₆H₂₉ClN₄O
SMILES

CC#CC1=CC(C2=CC([C@@]34N=C(C)C(N)=N4)=C(C[C@@]53CC[C@@H](OC)CC5)C=C2)=CN=C1.Cl
Synonyms

AZD-3293 hydrochloride; LY3314814 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Neurogastroenterol Motil

Studying the Role of Myenteric Amyloidosis in Gastrointestinal Dysmotility and Enteric Neural Dysfunction Using APP/PS1 Mice-Is It an Adequate Animal Model?. [Abstract]

2025 Sep;37(9):e70056. PMID: 40317839
SSRN

2025 Jul 25.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lanabecestat: Neuroimaging results in early symptomatic Alzheimer's disease [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Lanabecestat hydrochloride

2 Cited Publications

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Biological Activity
- Description
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References

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Lanabecestat hydrochloride

Publications Citing Use of MedChemExpress (MCE) Lanabecestat hydrochloride

All Beta-secretase Isoforms

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

Lanabecestat hydrochloride Related Classifications

HY-100740A Related Classifications