1. Neuronal Signaling
  2. Beta-secretase
  3. (1α,1'S,4β)-Lanabecestat

(1α,1'S,4β)-Lanabecestat (Synonyms: (1α,1'S,4β)-AZD3293; (1α,1'S,4β)-LY3314814)

Cat. No.: HY-100740C Purity: 97.20% ee.: 99.83%
Handling Instructions

(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) is a Beta site APP Cleaving Enzymel (BACE1) inhibitor extracted from patent WO2012087237A1, compound 20a, has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), respectively.

For research use only. We do not sell to patients.

(1α,1'S,4β)-Lanabecestat Chemical Structure

(1α,1'S,4β)-Lanabecestat Chemical Structure

CAS No. : 1384082-96-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 227 In-stock
Estimated Time of Arrival: December 31
2 mg USD 140 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (1α,1'S,4β)-Lanabecestat:

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Description

(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) is a Beta site APP Cleaving Enzymel (BACE1) inhibitor extracted from patent WO2012087237A1, compound 20a, has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), respectively[1].

Molecular Weight

412.53

Formula

C₂₆H₂₈N₄O

CAS No.

1384082-96-5

SMILES

NC(C(C)=N1)=N[[email protected]]21C3=C(C=CC(C4=CC(C#CC)=CN=C4)=C3)C[[email protected]]52CC[[email protected]@H](OC)CC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (606.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4241 mL 12.1203 mL 24.2407 mL
5 mM 0.4848 mL 2.4241 mL 4.8481 mL
10 mM 0.2424 mL 1.2120 mL 2.4241 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (5.26 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(1α,1'S,4β)-Lanabecestat(1α,1'S,4β)-AZD3293(1α,1'S,4β)-LY3314814Beta-secretaseBACEβ-SecretaseInhibitorinhibitorinhibit

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Product name:
(1α,1'S,4β)-Lanabecestat
Cat. No.:
HY-100740C
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