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Methyllycaconitine

(Synonyms: MLA)
48 Cited Publications
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Based on 48 publication(s) in Google Scholar

Methyllycaconitine (MLA) is a potent, selective, CNS-penetrant, competitive α7nAChR antagonist. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum. Methyllycaconitine can be used for neurological disease research, such as Alzheimer’s disease .

For research use only. We do not sell to patients.

  • CAS No.: 21019-30-7
  • Formula: C37H50N2O10
  • Molecular Weight:682.80
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Methyllycaconitine Chemical Structure
    Methyllycaconitine Chemical Structure
  • Experimental Validation Results for Methyllycaconitine
  • Experimental Validation Results for Methyllycaconitine
  • Experimental Validation Results for Methyllycaconitine
  • Experimental Validation Results for Methyllycaconitine
  • Experimental Validation Results for Methyllycaconitine
  • Experimental Validation Results for Methyllycaconitine
  • Experimental Validation Results for Methyllycaconitine
CAS No.: 21019-30-7
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In Vivo ImagingWBRT-PCRHistological Imaging/StainingIn Vivo Efficacy Study
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  • Methyllycaconitine Chemical Structure
    Methyllycaconitine Chemical Structure
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    Methyllycaconitine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 14:e00945. [Abstract]

    Customer Validation
     3D reconstruction of micro-CT scanned images of the mouse alveolar bone. GTS-21 or MLA were administered in combination with EA in the LIP + SD + EA group, GTS-21 inhibited the progression of bone resorption, whereas Methyllycaconitine (MLA; 6 mg/kg; i.p. daily for 7 d) exacerbated it.

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    Methyllycaconitine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 14:e00945. [Abstract]

    Customer Validation
     Mouse periodontal tissues mRNA expression of pro-inflammatory-related genes IL-1β), IL-6, TNF-α, and anti-inflammatory-related gene IL-10. LIP+SD (LIP with sleep deprivation); EA (10 Hz, 1 mA, square wave) ; GTS-21 (4 mg/kg; i.p. daily for 7 d); Methyllycaconitine (MLA; 6 mg/kg; i.p. daily for 7 d).

  • 1/16

    Methyllycaconitine purchased from MedChemExpress. Usage Cited in: Diabetologia. 2025 Dec 15. [Abstract]

    Customer Validation
     Immunoblot analysis of α7nAChR after co-IP with an anti-VDAC1 antibody in HTR8/SVneo cells treated with NG (Normal glucose), HG (High glucose), HG + PNU-282987 or HG + MLA (Methyllycaconitine; 24 h).

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    Methyllycaconitine purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Jul;45(7):1349-1365. [Abstract]

    Customer Validation
     TTC staining and quantification showing the blockade of VNS-induced reduction in infarct volume in the MLA (Methyllycaconitine; 2.5 mg/kg; i.p. 1 h before tMCAO model)-treated mice subjected to tMCAO model. Scale bar: 1.0 cm, n = 6.

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    Methyllycaconitine purchased from MedChemExpress. Usage Cited in: Inflamm Res. 2023 Apr;72(4):879-892. [Abstract]

    Customer Validation
     PNU-282987 (3 mg/kg; i.p.; single daily for consecutively 28 days) signifcantly decreases the expression levels of collagen I, collagen III, and α-SMA in myocardial infarction (MI) rats model, while Methyllycaconitine citrate (MLA; 3 mg/kg; i.p.; single daily for consecutively 28 days) increases these proteins levels.

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    Methyllycaconitine purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2021 Dec 17;18(1):291. [Abstract]

    Customer Validation
     Immunofluorescence staining of hippocampal sections in each group rats (IL-1β). The microglia transform from ameboid form (α7nAchR(−/−) + taVNS group and Hi MLA  (Methyllycaconitine; (80 μg/kg; 1-week continuous unilaterally local infusions)) + taVNS group) to ramified state (Hi saline + taVNS). Compared with α7nAchR(−/−) + taVNS group and Hi MLA + taVNS group, the co-expression between pro-inflammatory cytokine IL-1β (green) and microglia (red) decreased in Hi saline + taVNS group. IL-1β (green), Iba-1 (red), DAPI (blue), Merge (yellow).

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    Methyllycaconitine purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2021 Dec 17;18(1):291. [Abstract]

    Customer Validation
     The effect of α7nAchR in the hippocampus on the body mass and behavioral experiments of CUMS rats intervened by taVNS at different time points. MLA (Methyllycaconitine; 80 μg/kg; 1-week continuous unilaterally local infusions); taVNS (transcutaneous auricular vagus nerve stimulation).

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