1. Neuronal Signaling
  2. Amyloid-β
  3. Dihydroergocristine mesylate

Dihydroergocristine mesylate (Synonyms: DHEC (mesylate))

Cat. No.: HY-N2319 Purity: 99.86%
Handling Instructions

Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively.

For research use only. We do not sell to patients.

Dihydroergocristine mesylate Chemical Structure

Dihydroergocristine mesylate Chemical Structure

CAS No. : 24730-10-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 257 In-stock
Estimated Time of Arrival: December 31
5 mg USD 165 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively[1].

In Vitro

Dihydroergocristine (DHEC) (2-20 μM; 24 hours) has an IC50 value of 25 μM for inhibiting the activity of γ-secretase in T100 cells without affecting cell viability[1].
Dihydroergocristine (2-20 μM; 24 hours) inhibits cellular Aβ production and causes a dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs) in HEK293 and decreases γ-secretase activity in fibroblast cells[1].

Western Blot Analysis[1]

Cell Line: WT HEK293 cells; Fibroblast cells
Concentration: 2 μM, 5 μM, 10 μM, 20 μM
Incubation Time: 24 hours
Result: Increased APP-CTFs accumulation in a dose-dependent manner.
Molecular Weight

707.84

Formula

C₃₆H₄₅N₅O₈S

CAS No.

24730-10-7

SMILES

O[[email protected]@]([[email protected]@](CCC1)([H])N1C2=O)(O[[email protected]](NC([[email protected]@H](CN(C)[[email protected]]3([H])C4)C[[email protected]]3([H])C5=C6C4=CNC6=CC=C5)=O)(C(C)C)C7=O)N7[[email protected]]2CC8=CC=CC=C8.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (70.64 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4127 mL 7.0637 mL 14.1275 mL
5 mM 0.2825 mL 1.4127 mL 2.8255 mL
10 mM 0.1413 mL 0.7064 mL 1.4127 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product name:
Dihydroergocristine mesylate
Cat. No.:
HY-N2319
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