1. Neuronal Signaling
  2. Amyloid-β
  3. Dihydroergocristine mesylate

Dihydroergocristine mesylate (Synonyms: DHEC (mesylate))

Cat. No.: HY-N2319
Handling Instructions

Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively.

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Dihydroergocristine mesylate Chemical Structure

Dihydroergocristine mesylate Chemical Structure

CAS No. : 24730-10-7

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Description

Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively[1].

In Vitro

Dihydroergocristine (DHEC) (2-20 μM; 24 hours) has an IC50 value of 25 μM for inhibiting the activity of γ-secretase in T100 cells without affecting cell viability[1].
Dihydroergocristine (2-20 μM; 24 hours) inhibits cellular Aβ production and causes a dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs) in HEK293 and decreases γ-secretase activity in fibroblast cells[1].

Western Blot Analysis[1]

Cell Line: WT HEK293 cells; Fibroblast cells
Concentration: 2 μM, 5 μM, 10 μM, 20 μM
Incubation Time: 24 hours
Result: Increased APP-CTFs accumulation in a dose-dependent manner.
Molecular Weight

707.84

Formula

C₃₆H₄₅N₅O₈S

CAS No.

24730-10-7

SMILES

O[[email protected]@]([[email protected]@](CCC1)([H])N1C2=O)(O[[email protected]](NC([[email protected]@H](CN(C)[[email protected]]3([H])C4)C[[email protected]]3([H])C5=C6C4=CNC6=CC=C5)=O)(C(C)C)C7=O)N7[[email protected]]2CC8=CC=CC=C8.CS(=O)(O)=O

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Dihydroergocristine mesylate
Cat. No.:
HY-N2319
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