1. Neuronal Signaling
  2. Amyloid-β
  3. Tramiprosate

Tramiprosate (Synonyms: Homotaurine; 3-Amino-1-propanesulfonic acid)

Cat. No.: HY-14602 Purity: ≥98.0%
Handling Instructions

Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects.

For research use only. We do not sell to patients.

Tramiprosate Chemical Structure

Tramiprosate Chemical Structure

CAS No. : 3687-18-1

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10 mM * 1 mL in Water USD 55 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3].

In Vitro

Tramiprosate (200 μg/mL, 40 μg/mL, 8 μg/mL and 1.6 μg/mL; 1 hours) significantly attenuates oxygen/glucose deprivation (OGD)- or NMDA-induced injury in NGF-differentiated PC12 cells and primary cortical neurons. Tramiprosate decreases the intensity of the association between nNOS and PSD95, and Tramiprosate also inhibits the translocation of nNOS from the cytosol to the membrane[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tramiprosate (6.25-50 mg/kg; intraperitoneal injection; once) treatment dose-dependently reduces the infarct volume after MCAO. Tramiprosate (50 mg/kg) treatment shows a significant neurological functional recovery[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (200-250 g) subjected to middle cerebral artery occlusion (MCAO)[1]
Dosage: 50 mg/kg, 25 mg/kg, 12.5 mg/kg or 6.25 mg/kg
Administration: Intraperitoneal injection; once
Result: Dose-dependently reduced the infarct volume after MCAO.
Clinical Trial
Molecular Weight

139.17

Formula

C₃H₉NO₃S

CAS No.
SMILES

NCCCS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (143.71 mM; Need ultrasonic)

DMSO : 1 mg/mL (7.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.1855 mL 35.9273 mL 71.8546 mL
5 mM 1.4371 mL 7.1855 mL 14.3709 mL
10 mM 0.7185 mL 3.5927 mL 7.1855 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 140 mg/mL (1005.96 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

TramiprosateHomotaurine 3-Amino-1-propanesulfonic acidAmyloid-ββ-amyloid peptideAbetaNeuroprotectionanticonvulsionantihypertensionNMDAnNOSPSD95aminosulphonateAβ42Inhibitorinhibitorinhibit

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Product Name:
Tramiprosate
Cat. No.:
HY-14602
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