1. Neuronal Signaling
  2. Amyloid-β

Tramiprosate (Synonyms: Homotaurine; 3-Amino-1-propanesulfonic acid)

Cat. No.: HY-14602 Purity: >98.0%
Data Sheet SDS Handling Instructions

Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent deposition.

For research use only. We do not sell to patients.
Tramiprosate Chemical Structure

Tramiprosate Chemical Structure

CAS No. : 3687-18-1

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
1 g $50 In-stock
5 g $95 In-stock
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  • Biological Activity

  • Protocol

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  • References

Description

Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent deposition target: Aβ In vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors. Tramiprosate dose-dependently provides neuroprotection against ischemic stroke. In vivo: Tramiprosate produced dose-dependent reductions of Aβ in the brain of transgenic mice (hAPP-TgCRND8). Clinical studies show that tramiprosate was safe and tolerable. In mild-to-moderate AD patients tramiprosate also reduced Aβ42 levels in CSF. The reference for animal administration is 50 mg/kg.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT00314912 Bellus Health Inc Alzheimer's Disease May 2006 Phase 3
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References
Molecular Weight

139.17

Formula

C₃H₉NO₃S

CAS No.

3687-18-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Tramiprosate
Cat. No.:
HY-14602
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