AChE-IN-47
AChE-IN-47 (compound g17) is a AChE inhibitor with the IC50 of 0.24 μM. AChE-IN-47 inhibits amyloid β peptides self-aggregation. AChE-IN-47 displays neuroprotective effects and effectively suppresses the intracellular accumulation of reactive oxygen species.
For research use only. We do not sell to patients.
- CAS No.: 3033056-55-9
- Formula: C20H17F3N4O4S
- Molecular Weight:466.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AChE |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
1.69 μM
Compound: g17
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Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of IL-1beta production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of IL-1beta production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
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[PMID: 38052155] |
| BV-2 | IC50 |
3.34 μM
Compound: g17
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Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of NO production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent based assay
Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of NO production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent based assay
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[PMID: 38052155] |
| BV-2 | IC50 |
8.62 μM
Compound: g17
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Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of TNF-alpha production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of TNF-alpha production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
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[PMID: 38052155] |
Chemical Information
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CAS No. 3033056-55-9
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Molecular Weight 466.43
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Formula C20H17F3N4O4S
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SMILES
O=C(NC1=CC=C2C(N3CCCC3=NC2=C1)=O)CNS(=O)(C4=CC=CC=C4C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-47 Related Classifications
HY-157296 Related Classifications
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