AChE-IN-47
AChE-IN-47 (compound g17) is a AChE inhibitor with the IC50 of 0.24 μM. AChE-IN-47 inhibits amyloid β peptides self-aggregation. AChE-IN-47 displays neuroprotective effects and effectively suppresses the intracellular accumulation of reactive oxygen species.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 3033056-55-9
- Formel: C20H17F3N4O4S
- Molecular Weight:466.43
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
|
AChE |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
1.69 μM
Compound: g17
|
Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of IL-1beta production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of IL-1beta production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
|
[PMID: 38052155] |
| BV-2 | IC50 |
3.34 μM
Compound: g17
|
Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of NO production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent based assay
Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of NO production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent based assay
|
[PMID: 38052155] |
| BV-2 | IC50 |
8.62 μM
Compound: g17
|
Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of TNF-alpha production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
Anti-neuroinflammatory activity against LPS-induced mouse BV-2 cells assessed as inhibition of TNF-alpha production pre-incubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
|
[PMID: 38052155] |
Chemical Information
-
CAS. Nr. 3033056-55-9
-
Molecular Weight 466.43
-
Formel C20H17F3N4O4S
-
SMILES
O=C(NC1=CC=C2C(N3CCCC3=NC2=C1)=O)CNS(=O)(C4=CC=CC=C4C(F)(F)F)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AChE-IN-47 Related Classifications
HY-157296 Related Classifications
Powered by Bioz