60 Results for "

important stress

" in MedChemExpress (MCE) Product Catalog:
Products (60)

60 Results for "important stress" in MCE Product Catalog:

145
Melatonin
Melatonin
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145 Publications Verification
Cat. No.: HY-B0075
CAS No.: 73-31-4
Synonyms: N-Acetyl-5-methoxytryptamine
Category:  

Natural Products Neurological Disease Other disease Anti-aging Disease markers Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis PANoptosis Ligands for Target Protein for PROTAC Histone Acetyltransferase

Melatonin is a hormone made by the pineal gland that can activate melatonin receptor and inhibit PANoptosis. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .
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18
4-Hydroxynonenal
4-Hydroxynonenal
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18 Cited Publications
Cat. No.: HY-113466
CAS No.: 75899-68-2
Purity:  99.35%
Synonyms: 4-HNE
Category:  

Neurological Disease Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer

Target:  

Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite

4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .
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1
Acetyl phosphate lithium potassium
Acetyl phosphate lithium potassium
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1 Cited Publications
Cat. No.: HY-128730
CAS No.: 94249-01-1
Purity:  ≥98.0%
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Bacterial

Acetyl phosphate lithium potassium is an endogenous metabolic product. Acetyl phosphate lithium potassium is a key substance in bacterial metabolic regulation, particularly in Lysine acetylation, and plays an important role in bacterial responses to environmental stress and adaptive reactions .
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1
D-Glucose-13C
D-Glucose-13C
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1 Cited Publications
Cat. No.: HY-B0389S10
CAS No.: 101615-88-7
Synonyms: Glucose-13C; D-(+)-Glucose-13C; Dextrose-13C
D-Glucose- 13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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1
Homogentisic acid
Homogentisic acid
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1 Cited Publications
Cat. No.: HY-113283
CAS No.: 451-13-8
Purity:  99.46%
Category:  

Other disease Ketones, Aldehydes, Acids Disease markers Metabolic Disease Phenols Polyphenols Endogenous metabolite Disease Research Fields

Target:  

Amyloid-β Natriuretic Peptide Receptor (NPR) α-synuclein Transthyretin (TTR) Claudin

Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .
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1
Astressin 2B
Astressin 2B
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1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
Target:  

CRFR

Research Areas:  

Neurological Disease Inflammation/Immunology

Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .
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1
Astressin 2B TFA
Astressin 2B TFA
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1 Cited Publications
Cat. No.: HY-P1108A
Target:  

CRFR

Research Areas:  

Neurological Disease Inflammation/Immunology

Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .
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1
D-Glucose-13C2-4
D-Glucose-13C2-4
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1 Cited Publications
Cat. No.: HY-B0389S15
CAS No.: 138079-87-5
Synonyms: Glucose-13C2-4; D-(+)-Glucose-13C2-4; Dextrose-13C2-4
D-Glucose- 13C2-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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2',7'-Dichlorofluorescein
2',7'-Dichlorofluorescein
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Cat. No.: HY-W040143
CAS No.: 76-54-0
2',7'-Dichlorofluorescein is an important fluorescent product in the detection of oxidative stress and can be used to measure reactive oxygen species (ROS) (Ex=503 nm and Em=523 nm) .
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ER-Laurdan
ER-Laurdan
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Cat. No.: HY-N16308
CAS No.: 3091879-77-2
Category:  

Lipids

Target:  

Fluorescent Dye

ER-Laurdan is a derivative of the membrane-permeable fluorescent probe Laurdan (HY-D0080) that targets the endoplasmic reticulum (ER). As a membrane fluidity reporter, ER-Laurdan specifically localizes to the ER luminal membrane, and exhibits a prominent solvatochromic response to fluidity changes caused by membrane packing and exogenous saturated fatty acid stress. ER-Laurdan shows no overlapping localization with mitochondria, enables quantitative analysis of ER membrane fluidity via generalized polarization ratio measurement, and allows automatic signal masking with the help of ER markers. With high specificity and quantitative capability, ER-Laurdan serves as an important tool for investigating metabolic disorders and associated changes in the physical properties of cell membranes .
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Theaflavin-3-gallate
Theaflavin-3-gallate
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Cat. No.: HY-N0245
CAS No.: 30462-34-1
Category:  

Flavonoids Flavanols Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Cancer Theaceae

Target:  

Apoptosis MDM-2/p53 ATM/ATR Checkpoint Kinase (Chk)

Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner. Theaflavin-3-gallate induces apoptosis and G1 cell cycle arrest in ovarian cancer A2780/CP70 cells through p53-dependent pathways. Theaflavin-3-gallate induces DNA damage through ATM/Chk/p53 pathway .
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Galactinol
Galactinol
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Cat. No.: HY-N9497
CAS No.: 3687-64-7
Category:  

Natural Products

Target:  

Galectin Fungal

Galactinol is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot .
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D-Glucose-1-13C
D-Glucose-1-13C
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Cat. No.: HY-B0389S16
CAS No.: 40762-22-9
Synonyms: Glucose-1-13C; D-(+)-Glucose-1-13C; Dextrose-1-13C
D-Glucose-1- 13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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Melatonin-d3
Melatonin-d3
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Cat. No.: HY-B0075S1
CAS No.: 90735-69-6
Synonyms: N-Acetyl-5-methoxytryptamine-d3
Melatonin-d3 is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .
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Melatonin (standard)
Melatonin (standard)
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Cat. No.: HY-B0075R
CAS No.: 73-31-4
Synonyms: N-Acetyl-5-methoxytryptamine (standard); Melatonin
Category:  

Natural Products Microorganisms Other disease Disease markers Endogenous metabolite

Target:  

Reference Standards Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis

Melatonin (Standard) is the analytical standard of Melatonin. This product is intended for research and analytical applications. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .
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Chlorimuron-ethyl
Chlorimuron-ethyl
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Cat. No.: HY-W040262
CAS No.: 90982-32-4
Target:  

Environmental Pollutants Herbicide

Research Areas:  

Others

Chlorimuron-ethyl induces oxidative stress. Chlorimuron-ethyl is an important herbicide that has been widely used in soybean production .
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Oncaspar
Oncaspar
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Cat. No.: HY-108860
CAS No.: 130167-69-0
Purity:  ≥99.0%
Synonyms: PEG-L-asparaginase; Pegasparaginase
Target:  

FGFR Interleukin Related

Research Areas:  

Inflammation/Immunology

Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL) through asparagine hydrolysis and activation of the integrated stress response (ISR) pathway .
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D-Glucose-d2
D-Glucose-d2
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Cat. No.: HY-B0389S5
CAS No.: 18991-62-3
Synonyms: Glucose-d2; D-(+)-Glucose-d2; Dextrose-d2
D-Glucose-d2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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D-Glucose-d7
D-Glucose-d7
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Cat. No.: HY-B0389S6
CAS No.: 66034-51-3
Synonyms: Glucose-d7; D-(+)-Glucose-d7; Dextrose-d7
D-Glucose-d77 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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4-Hydroxynonenal-d3
4-Hydroxynonenal-d3
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Cat. No.: HY-113466S
CAS No.: 148706-06-3
Purity:  99.0%
Synonyms: 4-HNE-d3
4-Hydroxynonenal-d3 is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .
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