Neuropeptide W-30 (human)  (Synonyms: NPW30, human)

Neuropeptide W-30 (human) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (human) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. Neuropeptide W-30 (human) activates and binds to both GPR7 and GPR8 at similar effective doses^[1][2][3].

3543.11

C₁₆₅H₂₄₉N₄₉O₃₇S

383415-80-3

Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Met-Gly-Leu-Arg-Arg-Ser-Pro-Tyr-Leu-Trp

WYKHVASPRYHTVGRAAGLLMGLRRSPYLW

O=C([C@H]1N(CCC1)C([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC(CNC([C@H](CCSC)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CNC([C@H](C)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](C(C)C)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H]2N(CCC2)C([C@H](CO)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@@H](N)CC3=CNC4=CC=CC=C34)=O)CC5=CC=C(C=C5)O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O)CC7=CC=C(C=C7)O)=O)CC8=CN=CN8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N[C@@H](CC9=CC=C(C=C9)O)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)=O

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• [1]. Makoto Kawasaki, et al. Centrally administered neuropeptide W-30 activates magnocellular neurosecretory cells in the supraoptic and paraventricular nuclei with neurosecretion in rats. J Endocrinol. 2006 Aug;190(2):213-23.  [Content Brief]

  [2]. Nan-Shou Yu, et al. Effects of intracerebroventricular administration of neuropeptide W30 on neurons in the hypothalamic paraventricular nucleus in the conscious rat. Neurosci Lett. 2007 Mar 26;415(2):140-5.  [Content Brief]

  [3]. Yukio Shimomura, et al. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. J Biol Chem. 2002 Sep 27;277(39):35826-32.  [Content Brief]